FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018083717> ?p ?o ?g. }

• W2018083717 endingPage "1143" @default.
• W2018083717 startingPage "1137" @default.
• W2018083717 abstract "Matrix metalloproteinase 2 (MMP-2)/gelatinase A plays an important role in tumour invasion and metastasis. Since MMP-2 is secreted as an inactive form (proMMP-2) from tumour and neighbouring stroma cells, the activation process is necessary to express the enzymic activity for degradation of extracellular matrix components. We herein reported that the activation of proMMP-2 was induced in human squamous carcinoma cells co-cultured with normal human dermal fibroblasts. When A431 cells were co-cultured with human fibroblasts at various cell ratios, 72-kDa proMMP-2 was converted to a 62-kDa active form through the appearance of a 64-kDa intermediate. The activation of proMMP-2 by co-culture was also observed in other carcinoma cell lines, HSC-4 and SAS, but not in normal human keratinocytes. We characterized by in vitro invasion assay that A431 cells in co-culture preferentially invaded through Matrigel and the increased invasive activity was inhibited by exogenously adding tissue inhibitor of metalloproteinases 2. The augmented proMMP-2 activation by co-culture was achieved by the increase in membrane type 1-MMP (MT1-MMP) production along with that of its mRNA level. The predominant appearance of MT1-MMP was immunologically observed in A431 cells, but not human fibroblasts of the co-culture. Furthermore, epidermal growth factor (EGF) enhanced the co-culture-mediated proMMP-2 activation by increasing the production and gene expression of MT1-MMP, and thereby tumour invasive activity was further augmented. These results suggest that the cell-cell contact between carcinoma cells and normal fibroblasts enhances the production of MT1-MMP followed by sequential activation of proMMP-2 on the tumour cell surface, which may be closely implicated in tumour invasion in vivo." @default.
• W2018083717 created "2016-06-24" @default.
• W2018083717 creator A5006113054 @default.
• W2018083717 creator A5008902984 @default.
• W2018083717 creator A5052103080 @default.
• W2018083717 creator A5070825498 @default.
• W2018083717 creator A5071354099 @default.
• W2018083717 creator A5072959750 @default.
• W2018083717 creator A5083751001 @default.
• W2018083717 date "1999-05-28" @default.
• W2018083717 modified "2023-10-06" @default.
• W2018083717 title "Enhancement of membrane-type 1-matrix metalloproteinase (MT1-MMP) production and sequential activation of progelatinase A on human squamous carcinoma cells co-cultured with human dermal fibroblasts" @default.
• W2018083717 cites W1482195692 @default.
• W2018083717 cites W1492594459 @default.
• W2018083717 cites W1501830850 @default.
• W2018083717 cites W1501988955 @default.
• W2018083717 cites W1518735225 @default.
• W2018083717 cites W1537211771 @default.
• W2018083717 cites W1541757411 @default.
• W2018083717 cites W1548752314 @default.
• W2018083717 cites W157811826 @default.
• W2018083717 cites W1775749144 @default.
• W2018083717 cites W1846470953 @default.
• W2018083717 cites W1894541755 @default.
• W2018083717 cites W1914602305 @default.
• W2018083717 cites W1969111387 @default.
• W2018083717 cites W1974218266 @default.
• W2018083717 cites W1979390430 @default.
• W2018083717 cites W1986265345 @default.
• W2018083717 cites W2010640454 @default.
• W2018083717 cites W2018289835 @default.
• W2018083717 cites W2020973067 @default.
• W2018083717 cites W2030255734 @default.
• W2018083717 cites W2030680549 @default.
• W2018083717 cites W2032025051 @default.
• W2018083717 cites W2042502127 @default.
• W2018083717 cites W2043250294 @default.
• W2018083717 cites W2049220062 @default.
• W2018083717 cites W2052626837 @default.
• W2018083717 cites W2052973016 @default.
• W2018083717 cites W2055360422 @default.
• W2018083717 cites W2063421812 @default.
• W2018083717 cites W2065901487 @default.
• W2018083717 cites W2068843202 @default.
• W2018083717 cites W2074005418 @default.
• W2018083717 cites W2074048076 @default.
• W2018083717 cites W2074409617 @default.
• W2018083717 cites W2092449976 @default.
• W2018083717 cites W2100837269 @default.
• W2018083717 cites W2101564903 @default.
• W2018083717 cites W2121164372 @default.
• W2018083717 cites W2126091070 @default.
• W2018083717 cites W2149734677 @default.
• W2018083717 cites W4240447878 @default.
• W2018083717 doi "https://doi.org/10.1038/sj.bjc.6690477" @default.
• W2018083717 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2362364" @default.
• W2018083717 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10376963" @default.
• W2018083717 hasPublicationYear "1999" @default.
• W2018083717 type Work @default.
• W2018083717 sameAs 2018083717 @default.
• W2018083717 citedByCount "42" @default.
• W2018083717 countsByYear W20180837172016 @default.
• W2018083717 countsByYear W20180837172017 @default.
• W2018083717 countsByYear W20180837172022 @default.
• W2018083717 crossrefType "journal-article" @default.
• W2018083717 hasAuthorship W2018083717A5006113054 @default.
• W2018083717 hasAuthorship W2018083717A5008902984 @default.
• W2018083717 hasAuthorship W2018083717A5052103080 @default.
• W2018083717 hasAuthorship W2018083717A5070825498 @default.
• W2018083717 hasAuthorship W2018083717A5071354099 @default.
• W2018083717 hasAuthorship W2018083717A5072959750 @default.
• W2018083717 hasAuthorship W2018083717A5083751001 @default.
• W2018083717 hasBestOaLocation W20180837171 @default.
• W2018083717 hasConcept C109523444 @default.
• W2018083717 hasConcept C1491633281 @default.
• W2018083717 hasConcept C153911025 @default.
• W2018083717 hasConcept C185592680 @default.
• W2018083717 hasConcept C189165786 @default.
• W2018083717 hasConcept C2776223131 @default.
• W2018083717 hasConcept C2776232661 @default.
• W2018083717 hasConcept C2777546739 @default.
• W2018083717 hasConcept C2778608917 @default.
• W2018083717 hasConcept C2994460389 @default.
• W2018083717 hasConcept C502942594 @default.
• W2018083717 hasConcept C54355233 @default.
• W2018083717 hasConcept C55493867 @default.
• W2018083717 hasConcept C55728118 @default.
• W2018083717 hasConcept C81885089 @default.
• W2018083717 hasConcept C86803240 @default.
• W2018083717 hasConcept C95444343 @default.
• W2018083717 hasConceptScore W2018083717C109523444 @default.
• W2018083717 hasConceptScore W2018083717C1491633281 @default.
• W2018083717 hasConceptScore W2018083717C153911025 @default.
• W2018083717 hasConceptScore W2018083717C185592680 @default.
• W2018083717 hasConceptScore W2018083717C189165786 @default.
• W2018083717 hasConceptScore W2018083717C2776223131 @default.
• W2018083717 hasConceptScore W2018083717C2776232661 @default.
• W2018083717 hasConceptScore W2018083717C2777546739 @default.

• next