Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018084039> ?p ?o ?g. }
- W2018084039 endingPage "2908" @default.
- W2018084039 startingPage "2898" @default.
- W2018084039 abstract "Melanoma cells facilitate endothelial gap formation, the first step during tumor transendothelial migration, which is mediated by both adhesion and endogenously produced chemokines (in particular, interleukin-8 (IL-8)). Tetraspanins are localized to the cell surface in cancer and participate in various functions including invasion of tissues mediated by secretion of cytokines and matrix metalloproteinases. However, little is known about the role of CD82 tetraspanins in malignant melanomas during cancer cell invasion. In this study, we investigated the functional importance of CD82 expression in melanoma-mediated gap formation by using cDNAs to induce CD82 expression in highly invasive melanoma cell lines. Results showed that CD82 expression inhibited melanoma cell-induced gap formation, melanoma cell extravasation in vitro and subsequent lung metastasis development in vivo. Mechanistic studies showed that inducible expression of CD82 in highly metastatic melanoma cells significantly increased p21 expression upon binding of Duffy antigen receptor group (DARC), inducing tumor cell senescence and interrupting IL-8-mediated vascular endothelial (VE)-cadherin disassembly. Taken together, these studies provide a rationale for using drug therapies that restore CD82 expression and inhibit IL-8 production to inhibit late-stage melanoma cell extravasation and subsequent metastasis development." @default.
- W2018084039 created "2016-06-24" @default.
- W2018084039 creator A5012574298 @default.
- W2018084039 creator A5027804992 @default.
- W2018084039 creator A5037274418 @default.
- W2018084039 creator A5058737860 @default.
- W2018084039 creator A5087345379 @default.
- W2018084039 date "2013-07-22" @default.
- W2018084039 modified "2023-10-14" @default.
- W2018084039 title "CD82/KAI expression prevents IL-8-mediated endothelial gap formation in late-stage melanomas" @default.
- W2018084039 cites W1564674105 @default.
- W2018084039 cites W1963591953 @default.
- W2018084039 cites W1973927289 @default.
- W2018084039 cites W1984109999 @default.
- W2018084039 cites W1987561330 @default.
- W2018084039 cites W1988652526 @default.
- W2018084039 cites W1988981293 @default.
- W2018084039 cites W1991611623 @default.
- W2018084039 cites W1998770945 @default.
- W2018084039 cites W2000085355 @default.
- W2018084039 cites W2004173014 @default.
- W2018084039 cites W2005736556 @default.
- W2018084039 cites W2018114151 @default.
- W2018084039 cites W2021917597 @default.
- W2018084039 cites W2044341880 @default.
- W2018084039 cites W2045562838 @default.
- W2018084039 cites W2050242039 @default.
- W2018084039 cites W2056258550 @default.
- W2018084039 cites W2057065967 @default.
- W2018084039 cites W2057711788 @default.
- W2018084039 cites W2068446306 @default.
- W2018084039 cites W2071753279 @default.
- W2018084039 cites W2073955698 @default.
- W2018084039 cites W2076527846 @default.
- W2018084039 cites W2079375104 @default.
- W2018084039 cites W2081527131 @default.
- W2018084039 cites W2088052038 @default.
- W2018084039 cites W2090282678 @default.
- W2018084039 cites W2092180337 @default.
- W2018084039 cites W2100568503 @default.
- W2018084039 cites W2107997863 @default.
- W2018084039 cites W2108179736 @default.
- W2018084039 cites W2110567472 @default.
- W2018084039 cites W2112087685 @default.
- W2018084039 cites W2113641572 @default.
- W2018084039 cites W2117190940 @default.
- W2018084039 cites W2118832127 @default.
- W2018084039 cites W2123105952 @default.
- W2018084039 cites W2125037724 @default.
- W2018084039 cites W2127205087 @default.
- W2018084039 cites W2129970354 @default.
- W2018084039 cites W2130997087 @default.
- W2018084039 cites W2133776282 @default.
- W2018084039 cites W2143747809 @default.
- W2018084039 cites W2145345239 @default.
- W2018084039 cites W2170037266 @default.
- W2018084039 cites W2170121153 @default.
- W2018084039 cites W4232925121 @default.
- W2018084039 cites W76264893 @default.
- W2018084039 doi "https://doi.org/10.1038/onc.2013.249" @default.
- W2018084039 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23873025" @default.
- W2018084039 hasPublicationYear "2013" @default.
- W2018084039 type Work @default.
- W2018084039 sameAs 2018084039 @default.
- W2018084039 citedByCount "27" @default.
- W2018084039 countsByYear W20180840392014 @default.
- W2018084039 countsByYear W20180840392015 @default.
- W2018084039 countsByYear W20180840392016 @default.
- W2018084039 countsByYear W20180840392017 @default.
- W2018084039 countsByYear W20180840392018 @default.
- W2018084039 countsByYear W20180840392019 @default.
- W2018084039 countsByYear W20180840392020 @default.
- W2018084039 countsByYear W20180840392021 @default.
- W2018084039 countsByYear W20180840392022 @default.
- W2018084039 countsByYear W20180840392023 @default.
- W2018084039 crossrefType "journal-article" @default.
- W2018084039 hasAuthorship W2018084039A5012574298 @default.
- W2018084039 hasAuthorship W2018084039A5027804992 @default.
- W2018084039 hasAuthorship W2018084039A5037274418 @default.
- W2018084039 hasAuthorship W2018084039A5058737860 @default.
- W2018084039 hasAuthorship W2018084039A5087345379 @default.
- W2018084039 hasBestOaLocation W20180840391 @default.
- W2018084039 hasConcept C121608353 @default.
- W2018084039 hasConcept C13373296 @default.
- W2018084039 hasConcept C1491633281 @default.
- W2018084039 hasConcept C203014093 @default.
- W2018084039 hasConcept C2776914184 @default.
- W2018084039 hasConcept C2777658100 @default.
- W2018084039 hasConcept C2779013556 @default.
- W2018084039 hasConcept C2779540182 @default.
- W2018084039 hasConcept C502942594 @default.
- W2018084039 hasConcept C54355233 @default.
- W2018084039 hasConcept C86803240 @default.
- W2018084039 hasConceptScore W2018084039C121608353 @default.
- W2018084039 hasConceptScore W2018084039C13373296 @default.
- W2018084039 hasConceptScore W2018084039C1491633281 @default.
- W2018084039 hasConceptScore W2018084039C203014093 @default.
- W2018084039 hasConceptScore W2018084039C2776914184 @default.