FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018085271> ?p ?o ?g. }

• W2018085271 endingPage "243" @default.
• W2018085271 startingPage "238" @default.
• W2018085271 abstract "Superoxide dismutase (SOD) catalyzes the conversion of superoxide to hydrogen peroxide. Heterozygous mice of strain B6;129S7-Sod1tm1Leb/J were obtained from Jackson Laboratories and bred to produce offspring that were heterozygous (+/Sod1tm1Leb), homozygous wild-type (+/+), and homozygous knockout (Sod1tm1Leb/Sod1tm1Leb) for the Cu/Zn superoxide dismutase (Sod1) gene. Splenocytes from these mice were exposed to several concentrations of either sodium arsenite (As3 [0–200 μM]), monomethylarsonous acid (MMA3 [0–10 μM]), or dimethylarsinous acid (DMA3 [0–10 μM]) for 2 hr. Cells were then examined for DNA damage using the alkaline single cell gel electrophoresis assay. Methyl methanesulfonate (MMS) was used as a positive control. Splenocytes from each of the three genotypes for Sod1 were equally sensitive to MMS and As3. However, at equimolar concentrations, DMA3 and MMA3 produced significantly more DNA damage in the homozygous knockout mouse splenocytes than in the splenocytes from the wild-type or heterozygous mice. These findings suggest that superoxide is involved either directly or indirectly in producing DNA damage in cells exposed to trivalent methylated arsenicals. These arsenicals may generate reactive oxygen species that damage DNA. This DNA damage may be a key factor in initiating cancer in vivo. Environ. Mol. Mutagen., 2011. Published 2010 Wiley-Liss, Inc." @default.
• W2018085271 created "2016-06-24" @default.
• W2018085271 creator A5000991227 @default.
• W2018085271 creator A5086718525 @default.
• W2018085271 date "2010-08-25" @default.
• W2018085271 modified "2023-09-23" @default.
• W2018085271 title "Superoxide dismutase protects cells from DNA damage induced by trivalent methylated arsenicals" @default.
• W2018085271 cites W1964175376 @default.
• W2018085271 cites W1972754197 @default.
• W2018085271 cites W1973290552 @default.
• W2018085271 cites W1977896790 @default.
• W2018085271 cites W1979861889 @default.
• W2018085271 cites W1981247000 @default.
• W2018085271 cites W1996694599 @default.
• W2018085271 cites W1999348621 @default.
• W2018085271 cites W2028098070 @default.
• W2018085271 cites W2029523706 @default.
• W2018085271 cites W2034904269 @default.
• W2018085271 cites W2035029439 @default.
• W2018085271 cites W2036956155 @default.
• W2018085271 cites W2043329811 @default.
• W2018085271 cites W2044194141 @default.
• W2018085271 cites W2044597069 @default.
• W2018085271 cites W2045574831 @default.
• W2018085271 cites W2053299183 @default.
• W2018085271 cites W2059345484 @default.
• W2018085271 cites W2068949562 @default.
• W2018085271 cites W2076198146 @default.
• W2018085271 cites W2081371563 @default.
• W2018085271 cites W2101741084 @default.
• W2018085271 cites W2129774057 @default.
• W2018085271 cites W4237229177 @default.
• W2018085271 cites W4254568367 @default.
• W2018085271 doi "https://doi.org/10.1002/em.20609" @default.
• W2018085271 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20740636" @default.
• W2018085271 hasPublicationYear "2010" @default.
• W2018085271 type Work @default.
• W2018085271 sameAs 2018085271 @default.
• W2018085271 citedByCount "17" @default.
• W2018085271 countsByYear W20180852712012 @default.
• W2018085271 countsByYear W20180852712013 @default.
• W2018085271 countsByYear W20180852712014 @default.
• W2018085271 countsByYear W20180852712015 @default.
• W2018085271 countsByYear W20180852712016 @default.
• W2018085271 countsByYear W20180852712018 @default.
• W2018085271 countsByYear W20180852712021 @default.
• W2018085271 countsByYear W20180852712022 @default.
• W2018085271 countsByYear W20180852712023 @default.
• W2018085271 crossrefType "journal-article" @default.
• W2018085271 hasAuthorship W2018085271A5000991227 @default.
• W2018085271 hasAuthorship W2018085271A5086718525 @default.
• W2018085271 hasConcept C143425029 @default.
• W2018085271 hasConcept C153911025 @default.
• W2018085271 hasConcept C178790620 @default.
• W2018085271 hasConcept C181199279 @default.
• W2018085271 hasConcept C185592680 @default.
• W2018085271 hasConcept C189976730 @default.
• W2018085271 hasConcept C202751555 @default.
• W2018085271 hasConcept C2775838275 @default.
• W2018085271 hasConcept C2776151105 @default.
• W2018085271 hasConcept C2776639595 @default.
• W2018085271 hasConcept C2777615887 @default.
• W2018085271 hasConcept C2779495234 @default.
• W2018085271 hasConcept C2780795997 @default.
• W2018085271 hasConcept C48349386 @default.
• W2018085271 hasConcept C502230775 @default.
• W2018085271 hasConcept C552990157 @default.
• W2018085271 hasConcept C55493867 @default.
• W2018085271 hasConcept C86803240 @default.
• W2018085271 hasConceptScore W2018085271C143425029 @default.
• W2018085271 hasConceptScore W2018085271C153911025 @default.
• W2018085271 hasConceptScore W2018085271C178790620 @default.
• W2018085271 hasConceptScore W2018085271C181199279 @default.
• W2018085271 hasConceptScore W2018085271C185592680 @default.
• W2018085271 hasConceptScore W2018085271C189976730 @default.
• W2018085271 hasConceptScore W2018085271C202751555 @default.
• W2018085271 hasConceptScore W2018085271C2775838275 @default.
• W2018085271 hasConceptScore W2018085271C2776151105 @default.
• W2018085271 hasConceptScore W2018085271C2776639595 @default.
• W2018085271 hasConceptScore W2018085271C2777615887 @default.
• W2018085271 hasConceptScore W2018085271C2779495234 @default.
• W2018085271 hasConceptScore W2018085271C2780795997 @default.
• W2018085271 hasConceptScore W2018085271C48349386 @default.
• W2018085271 hasConceptScore W2018085271C502230775 @default.
• W2018085271 hasConceptScore W2018085271C552990157 @default.
• W2018085271 hasConceptScore W2018085271C55493867 @default.
• W2018085271 hasConceptScore W2018085271C86803240 @default.
• W2018085271 hasIssue "3" @default.
• W2018085271 hasLocation W20180852711 @default.
• W2018085271 hasLocation W20180852712 @default.
• W2018085271 hasOpenAccess W2018085271 @default.
• W2018085271 hasPrimaryLocation W20180852711 @default.
• W2018085271 hasRelatedWork W2018085271 @default.
• W2018085271 hasRelatedWork W2037464729 @default.
• W2018085271 hasRelatedWork W2073260254 @default.
• W2018085271 hasRelatedWork W2117809455 @default.
• W2018085271 hasRelatedWork W2120851516 @default.
• W2018085271 hasRelatedWork W2149278013 @default.

• next