FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018085295> ?p ?o ?g. }

• W2018085295 endingPage "100" @default.
• W2018085295 startingPage "97" @default.
• W2018085295 abstract "Visual responses during wakefulness are dominated by inhibition, and this inhibition shapes visual selectivity by restricting the temporal and spatial extent of neural activity. Recordings performed under anaesthesia have invariably described neural activity in the visual cortex as the product of a balance between excitatory and inhibitory currents, and this relationship is thought to determine the selectivity of neurons to visual features. Matteo Carandini and colleagues now compare intracellular measurements of primary visual cortex made in anaesthetized and awake, behaving mice. They find that under anaesthesia, excitation and inhibition are balanced, but in the awake state, inhibition is stronger and occurs for a broader spatial range of stimuli. They conclude that during wakefulness, visual responses are dominated by inhibition, and that this shapes visual selectivity by restricting the temporal and spatial extent of responses. The activity of the cerebral cortex is thought to depend on the precise relationship between synaptic excitation and inhibition1,2,3,4. In the visual cortex, in particular, intracellular measurements have related response selectivity to coordinated increases in excitation and inhibition5,6,7,8,9. These measurements, however, have all been made during anaesthesia, which strongly influences cortical state10 and therefore sensory processing7,11,12,13,14,15. The synaptic activity that is evoked by visual stimulation during wakefulness is unknown. Here we measured visually evoked responses—and the underlying synaptic conductances—in the visual cortex of anaesthetized and awake mice. Under anaesthesia, responses could be elicited from a large region of visual space16 and were prolonged. During wakefulness, responses were more spatially selective and much briefer. Whole-cell patch-clamp recordings of synaptic conductances5,17 showed a difference in synaptic inhibition between the two conditions. Under anaesthesia, inhibition tracked excitation in amplitude and spatial selectivity. By contrast, during wakefulness, inhibition was much stronger than excitation and had extremely broad spatial selectivity. We conclude that during wakefulness, cortical responses to visual stimulation are dominated by synaptic inhibition, restricting the spatial spread and temporal persistence of neural activity. These results provide a direct glimpse of synaptic mechanisms that control sensory responses in the awake cortex." @default.
• W2018085295 created "2016-06-24" @default.
• W2018085295 creator A5026654708 @default.
• W2018085295 creator A5036387453 @default.
• W2018085295 creator A5088723671 @default.
• W2018085295 date "2012-11-21" @default.
• W2018085295 modified "2023-10-11" @default.
• W2018085295 title "Inhibition dominates sensory responses in the awake cortex" @default.
• W2018085295 cites W1484716989 @default.
• W2018085295 cites W1623755432 @default.
• W2018085295 cites W1853766545 @default.
• W2018085295 cites W1972869628 @default.
• W2018085295 cites W1984202832 @default.
• W2018085295 cites W1986714849 @default.
• W2018085295 cites W1989893274 @default.
• W2018085295 cites W1992007613 @default.
• W2018085295 cites W1992828185 @default.
• W2018085295 cites W1997953085 @default.
• W2018085295 cites W2002108201 @default.
• W2018085295 cites W2007115135 @default.
• W2018085295 cites W2009759904 @default.
• W2018085295 cites W2041575547 @default.
• W2018085295 cites W2062624347 @default.
• W2018085295 cites W2067012111 @default.
• W2018085295 cites W2067485452 @default.
• W2018085295 cites W2072150567 @default.
• W2018085295 cites W2085026965 @default.
• W2018085295 cites W2093807483 @default.
• W2018085295 cites W2100064861 @default.
• W2018085295 cites W2103250872 @default.
• W2018085295 cites W2103775384 @default.
• W2018085295 cites W2106700142 @default.
• W2018085295 cites W2106797492 @default.
• W2018085295 cites W2120628526 @default.
• W2018085295 cites W2124196462 @default.
• W2018085295 cites W2124777856 @default.
• W2018085295 cites W2128523475 @default.
• W2018085295 cites W2139787850 @default.
• W2018085295 cites W2140552585 @default.
• W2018085295 cites W2145935269 @default.
• W2018085295 cites W2159749299 @default.
• W2018085295 cites W2165944199 @default.
• W2018085295 cites W2245948004 @default.
• W2018085295 cites W4295831928 @default.
• W2018085295 doi "https://doi.org/10.1038/nature11665" @default.
• W2018085295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3537822" @default.
• W2018085295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23172139" @default.
• W2018085295 hasPublicationYear "2012" @default.
• W2018085295 type Work @default.
• W2018085295 sameAs 2018085295 @default.
• W2018085295 citedByCount "484" @default.
• W2018085295 countsByYear W20180852952012 @default.
• W2018085295 countsByYear W20180852952013 @default.
• W2018085295 countsByYear W20180852952014 @default.
• W2018085295 countsByYear W20180852952015 @default.
• W2018085295 countsByYear W20180852952016 @default.
• W2018085295 countsByYear W20180852952017 @default.
• W2018085295 countsByYear W20180852952018 @default.
• W2018085295 countsByYear W20180852952019 @default.
• W2018085295 countsByYear W20180852952020 @default.
• W2018085295 countsByYear W20180852952021 @default.
• W2018085295 countsByYear W20180852952022 @default.
• W2018085295 countsByYear W20180852952023 @default.
• W2018085295 crossrefType "journal-article" @default.
• W2018085295 hasAuthorship W2018085295A5026654708 @default.
• W2018085295 hasAuthorship W2018085295A5036387453 @default.
• W2018085295 hasAuthorship W2018085295A5088723671 @default.
• W2018085295 hasBestOaLocation W20180852952 @default.
• W2018085295 hasConcept C112592302 @default.
• W2018085295 hasConcept C15744967 @default.
• W2018085295 hasConcept C169760540 @default.
• W2018085295 hasConcept C17077164 @default.
• W2018085295 hasConcept C185592680 @default.
• W2018085295 hasConcept C24998067 @default.
• W2018085295 hasConcept C2777348757 @default.
• W2018085295 hasConcept C2779320081 @default.
• W2018085295 hasConcept C2779345533 @default.
• W2018085295 hasConcept C2781041448 @default.
• W2018085295 hasConcept C522805319 @default.
• W2018085295 hasConcept C74254510 @default.
• W2018085295 hasConcept C94487597 @default.
• W2018085295 hasConceptScore W2018085295C112592302 @default.
• W2018085295 hasConceptScore W2018085295C15744967 @default.
• W2018085295 hasConceptScore W2018085295C169760540 @default.
• W2018085295 hasConceptScore W2018085295C17077164 @default.
• W2018085295 hasConceptScore W2018085295C185592680 @default.
• W2018085295 hasConceptScore W2018085295C24998067 @default.
• W2018085295 hasConceptScore W2018085295C2777348757 @default.
• W2018085295 hasConceptScore W2018085295C2779320081 @default.
• W2018085295 hasConceptScore W2018085295C2779345533 @default.
• W2018085295 hasConceptScore W2018085295C2781041448 @default.
• W2018085295 hasConceptScore W2018085295C522805319 @default.
• W2018085295 hasConceptScore W2018085295C74254510 @default.
• W2018085295 hasConceptScore W2018085295C94487597 @default.
• W2018085295 hasIssue "7430" @default.
• W2018085295 hasLocation W20180852951 @default.
• W2018085295 hasLocation W20180852952 @default.
• W2018085295 hasLocation W20180852953 @default.

• next