FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018086608> ?p ?o ?g. }

• W2018086608 endingPage "114" @default.
• W2018086608 startingPage "106" @default.
• W2018086608 abstract "Inflammatory bowel disease is a recurrent intestinal inflammatory disorder that in adults has been associated with changes in enteric nervous system neuropeptide expression. The aim of the present study was to determine whether similar changes were observed in paediatric Crohn's disease. The distribution of vasoactive intestinal peptide (VIP) and neuronal nitric oxide synthase (nNOS) was determined in colonic tissues from children with ileo-colonic (n=4) and colonic (n=3) Crohn's disease. The submucosal plexus of inflamed regions showed significant increase in density of VIP immunoreactive neurons (margin, 48% vs. inflamed tissue, 82% of HuC/D positive neurons). The density of submucosal plexus nNOS immunoreactive neurons was too low to be reliably quantified. Using the pan-neuronal marker HuC/D, no significant difference in numbers of HuC/D positive submucosal neurons was evident except where neurons were normalized to length of tissue (margins, 3.6±0.7 vs. inflamed tissue, 4.0±0.6 neurons/ganglia, p=0.33; margins, 2.7±0.4 vs. inflamed tissue, 5.7±1.2, neurons/mm, p=0.03). In the myenteric plexus, there was a significant increase in the percent of NOS neurons (38% vs. 82% of HuC/D positive neurons) while there was no significant difference in percent of VIP neurons (4% vs. 8%). No difference in number of HuC/D positive myenteric neurons among margin and inflamed tissues was observed (margin, 12.2±3.0 vs. inflamed tissue, 12.5±5.1 neurons/ganglia, p=0.50; margins 9.1±2.1 vs. inflamed tissue, 13.7±2.3 neurons/mm, p=0.11). These data demonstrate that inflammation is associated with a differential expression of VIP and nNOS neuronal subpopulations within the two major enteric plexi, likely due to phenotypic switch. Such changes might contribute to the pathogenesis of IBD and ongoing symptoms even in quiescent disease." @default.
• W2018086608 created "2016-06-24" @default.
• W2018086608 creator A5007625827 @default.
• W2018086608 creator A5010081184 @default.
• W2018086608 creator A5014588193 @default.
• W2018086608 creator A5045997570 @default.
• W2018086608 creator A5064945893 @default.
• W2018086608 date "2007-07-01" @default.
• W2018086608 modified "2023-10-15" @default.
• W2018086608 title "Differential responses of VIPergic and nitrergic neurons in paediatric patients with Crohn's disease" @default.
• W2018086608 cites W1468685218 @default.
• W2018086608 cites W1939349037 @default.
• W2018086608 cites W1970464559 @default.
• W2018086608 cites W1972326324 @default.
• W2018086608 cites W1974957349 @default.
• W2018086608 cites W1978748245 @default.
• W2018086608 cites W1983236785 @default.
• W2018086608 cites W1985694147 @default.
• W2018086608 cites W1999847499 @default.
• W2018086608 cites W2002150254 @default.
• W2018086608 cites W2004066632 @default.
• W2018086608 cites W2010372861 @default.
• W2018086608 cites W2033615486 @default.
• W2018086608 cites W2050708805 @default.
• W2018086608 cites W2054264840 @default.
• W2018086608 cites W2054928012 @default.
• W2018086608 cites W2056971114 @default.
• W2018086608 cites W2067213652 @default.
• W2018086608 cites W2068437984 @default.
• W2018086608 cites W2073454150 @default.
• W2018086608 cites W2087048554 @default.
• W2018086608 cites W2089752133 @default.
• W2018086608 cites W2097585375 @default.
• W2018086608 cites W2127209006 @default.
• W2018086608 cites W2130358771 @default.
• W2018086608 cites W2135442617 @default.
• W2018086608 cites W2146228378 @default.
• W2018086608 cites W2152168957 @default.
• W2018086608 cites W2165837344 @default.
• W2018086608 cites W2324912146 @default.
• W2018086608 cites W2594990674 @default.
• W2018086608 cites W4240101906 @default.
• W2018086608 doi "https://doi.org/10.1016/j.autneu.2007.03.001" @default.
• W2018086608 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17466601" @default.
• W2018086608 hasPublicationYear "2007" @default.
• W2018086608 type Work @default.
• W2018086608 sameAs 2018086608 @default.
• W2018086608 citedByCount "29" @default.
• W2018086608 countsByYear W20180866082012 @default.
• W2018086608 countsByYear W20180866082013 @default.
• W2018086608 countsByYear W20180866082014 @default.
• W2018086608 countsByYear W20180866082015 @default.
• W2018086608 countsByYear W20180866082017 @default.
• W2018086608 countsByYear W20180866082019 @default.
• W2018086608 countsByYear W20180866082020 @default.
• W2018086608 countsByYear W20180866082021 @default.
• W2018086608 countsByYear W20180866082022 @default.
• W2018086608 countsByYear W20180866082023 @default.
• W2018086608 crossrefType "journal-article" @default.
• W2018086608 hasAuthorship W2018086608A5007625827 @default.
• W2018086608 hasAuthorship W2018086608A5010081184 @default.
• W2018086608 hasAuthorship W2018086608A5014588193 @default.
• W2018086608 hasAuthorship W2018086608A5045997570 @default.
• W2018086608 hasAuthorship W2018086608A5064945893 @default.
• W2018086608 hasConcept C105702510 @default.
• W2018086608 hasConcept C118303440 @default.
• W2018086608 hasConcept C126322002 @default.
• W2018086608 hasConcept C134018914 @default.
• W2018086608 hasConcept C142724271 @default.
• W2018086608 hasConcept C170493617 @default.
• W2018086608 hasConcept C204232928 @default.
• W2018086608 hasConcept C2776907353 @default.
• W2018086608 hasConcept C2777439022 @default.
• W2018086608 hasConcept C2777622882 @default.
• W2018086608 hasConcept C2778260677 @default.
• W2018086608 hasConcept C2779134260 @default.
• W2018086608 hasConcept C2779280984 @default.
• W2018086608 hasConcept C2779988585 @default.
• W2018086608 hasConcept C519581460 @default.
• W2018086608 hasConcept C71924100 @default.
• W2018086608 hasConcept C8330315 @default.
• W2018086608 hasConceptScore W2018086608C105702510 @default.
• W2018086608 hasConceptScore W2018086608C118303440 @default.
• W2018086608 hasConceptScore W2018086608C126322002 @default.
• W2018086608 hasConceptScore W2018086608C134018914 @default.
• W2018086608 hasConceptScore W2018086608C142724271 @default.
• W2018086608 hasConceptScore W2018086608C170493617 @default.
• W2018086608 hasConceptScore W2018086608C204232928 @default.
• W2018086608 hasConceptScore W2018086608C2776907353 @default.
• W2018086608 hasConceptScore W2018086608C2777439022 @default.
• W2018086608 hasConceptScore W2018086608C2777622882 @default.
• W2018086608 hasConceptScore W2018086608C2778260677 @default.
• W2018086608 hasConceptScore W2018086608C2779134260 @default.
• W2018086608 hasConceptScore W2018086608C2779280984 @default.
• W2018086608 hasConceptScore W2018086608C2779988585 @default.
• W2018086608 hasConceptScore W2018086608C519581460 @default.
• W2018086608 hasConceptScore W2018086608C71924100 @default.
• W2018086608 hasConceptScore W2018086608C8330315 @default.

• next