FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018086887> ?p ?o ?g. }

• W2018086887 endingPage "102" @default.
• W2018086887 startingPage "93" @default.
• W2018086887 abstract "RTP801 is a newly discovered stress-response gene that is induced by hypoxia and other cell stress signals. Arsenic is a heavy metal that is linked to carcinogenesis in humans. Here, we investigated the mechanism by which arsenic induces RTP801 transcription. In HaCaT human keratinocytes, arsenite was able to induce a rapid rise in the RTP801 mRNA level. Correspondingly, arsenite treatment was capable of stimulating a 2.5 kb human RTP801 promoter. Such a stimulatory effect was inhibited by co-expression of superoxide dismutase or glutathione peroxidase, and was abrogated by N-acetylcysteine, implying that ROS (reactive oxygen species) were involved in transcriptional regulation of the RTP801 gene. A series of deletion studies with the promoter revealed a critical arsenic-responsive region between −1057 and −981 bp of the promoter. Point mutations of the putative Elk-1 site and the C/EBP (CCAAT/enhancer-binding protein) site within this region were able to reduce the stimulatory effect of arsenite, indicating that Elk-1 and C/EBP are involved in transcriptional regulation of the RTP801 gene by arsenite. Furthermore, a gel mobility-shift assay demonstrated that arsenite was able to mount the rapid formation of a protein complex that bound the arsenic-responsive region as well as the C/EBP-containing sequence. The arsenite stimulation on RTP801 transcription was partly mediated by the ERK (extracellular-signal-regulated kinase) pathway, since the effect of RTP801 was inhibited by a selective ERK inhibitor. In addition, overexpression of Elk-1 and C/EBPβ was able to elevate the promoter activity. Therefore these studies indicate that RTP801 is a transcriptional target of arsenic in human keratinocytes, and that arsenic and ROS production are linked to Elk-1 and C/EBP in the transcriptional control." @default.
• W2018086887 created "2016-06-24" @default.
• W2018086887 creator A5005649959 @default.
• W2018086887 creator A5015860750 @default.
• W2018086887 creator A5066988938 @default.
• W2018086887 creator A5088517899 @default.
• W2018086887 date "2005-11-08" @default.
• W2018086887 modified "2023-10-18" @default.
• W2018086887 title "Arsenite induces a cell stress-response gene, <i>RTP801</i>, through reactive oxygen species and transcription factors Elk-1 and CCAAT/enhancer-binding protein" @default.
• W2018086887 cites W10339573 @default.
• W2018086887 cites W1852811226 @default.
• W2018086887 cites W1966398962 @default.
• W2018086887 cites W1978510296 @default.
• W2018086887 cites W1983243403 @default.
• W2018086887 cites W1985850338 @default.
• W2018086887 cites W2007996640 @default.
• W2018086887 cites W2039307052 @default.
• W2018086887 cites W2051994734 @default.
• W2018086887 cites W2063327890 @default.
• W2018086887 cites W2065054319 @default.
• W2018086887 cites W2071131200 @default.
• W2018086887 cites W2077001140 @default.
• W2018086887 cites W2084352955 @default.
• W2018086887 cites W2093341871 @default.
• W2018086887 cites W2094646101 @default.
• W2018086887 cites W2101208037 @default.
• W2018086887 cites W2115820946 @default.
• W2018086887 cites W2129011493 @default.
• W2018086887 cites W2129346720 @default.
• W2018086887 cites W2140439419 @default.
• W2018086887 cites W2143464311 @default.
• W2018086887 cites W2144827275 @default.
• W2018086887 cites W2147993424 @default.
• W2018086887 cites W2162088045 @default.
• W2018086887 cites W2170597525 @default.
• W2018086887 cites W2415535115 @default.
• W2018086887 cites W4365787052 @default.
• W2018086887 doi "https://doi.org/10.1042/bj20050553" @default.
• W2018086887 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1317668" @default.
• W2018086887 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16008523" @default.
• W2018086887 hasPublicationYear "2005" @default.
• W2018086887 type Work @default.
• W2018086887 sameAs 2018086887 @default.
• W2018086887 citedByCount "59" @default.
• W2018086887 countsByYear W20180868872012 @default.
• W2018086887 countsByYear W20180868872013 @default.
• W2018086887 countsByYear W20180868872014 @default.
• W2018086887 countsByYear W20180868872015 @default.
• W2018086887 countsByYear W20180868872016 @default.
• W2018086887 countsByYear W20180868872017 @default.
• W2018086887 countsByYear W20180868872018 @default.
• W2018086887 countsByYear W20180868872019 @default.
• W2018086887 countsByYear W20180868872020 @default.
• W2018086887 countsByYear W20180868872021 @default.
• W2018086887 countsByYear W20180868872022 @default.
• W2018086887 countsByYear W20180868872023 @default.
• W2018086887 crossrefType "journal-article" @default.
• W2018086887 hasAuthorship W2018086887A5005649959 @default.
• W2018086887 hasAuthorship W2018086887A5015860750 @default.
• W2018086887 hasAuthorship W2018086887A5066988938 @default.
• W2018086887 hasAuthorship W2018086887A5088517899 @default.
• W2018086887 hasBestOaLocation W20180868872 @default.
• W2018086887 hasConcept C101762097 @default.
• W2018086887 hasConcept C104317684 @default.
• W2018086887 hasConcept C111936080 @default.
• W2018086887 hasConcept C118995209 @default.
• W2018086887 hasConcept C138885662 @default.
• W2018086887 hasConcept C149240914 @default.
• W2018086887 hasConcept C150194340 @default.
• W2018086887 hasConcept C153911025 @default.
• W2018086887 hasConcept C178790620 @default.
• W2018086887 hasConcept C179926584 @default.
• W2018086887 hasConcept C185592680 @default.
• W2018086887 hasConcept C202751555 @default.
• W2018086887 hasConcept C2776305511 @default.
• W2018086887 hasConcept C41895202 @default.
• W2018086887 hasConcept C48349386 @default.
• W2018086887 hasConcept C502230775 @default.
• W2018086887 hasConcept C55493867 @default.
• W2018086887 hasConcept C86339819 @default.
• W2018086887 hasConcept C86803240 @default.
• W2018086887 hasConcept C94966510 @default.
• W2018086887 hasConceptScore W2018086887C101762097 @default.
• W2018086887 hasConceptScore W2018086887C104317684 @default.
• W2018086887 hasConceptScore W2018086887C111936080 @default.
• W2018086887 hasConceptScore W2018086887C118995209 @default.
• W2018086887 hasConceptScore W2018086887C138885662 @default.
• W2018086887 hasConceptScore W2018086887C149240914 @default.
• W2018086887 hasConceptScore W2018086887C150194340 @default.
• W2018086887 hasConceptScore W2018086887C153911025 @default.
• W2018086887 hasConceptScore W2018086887C178790620 @default.
• W2018086887 hasConceptScore W2018086887C179926584 @default.
• W2018086887 hasConceptScore W2018086887C185592680 @default.
• W2018086887 hasConceptScore W2018086887C202751555 @default.
• W2018086887 hasConceptScore W2018086887C2776305511 @default.
• W2018086887 hasConceptScore W2018086887C41895202 @default.
• W2018086887 hasConceptScore W2018086887C48349386 @default.
• W2018086887 hasConceptScore W2018086887C502230775 @default.

• next