FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018087077> ?p ?o ?g. }

• W2018087077 endingPage "341" @default.
• W2018087077 startingPage "336" @default.
• W2018087077 abstract "The objectives of this study were to determine the toxicity of intratumoural/intrapleural SRL172 in addition to intradermal SRL172 and standard chemotherapy (mitomycin-C, vinblastine and cisplatin) in patients with malignant mesothelioma. Patients received chemotherapy (mitomycin-C: 8 mg m−2, vinblastine: 6 mg m−2, cisplatin 50 mg m−2) on a 3-weekly basis for up to six courses. IP SRL172 injections were given 3-weekly prior to chemotherapy and escalated in groups of three patients from 1 μg to 1 mg bacilli in 10-fold increments. Patients were also given ID SRL172 at a dose of 1 mg bacilli 4-weekly. Patients were assessed for toxicity after each course of chemotherapy and for response by CT imaging. Immuno-haematological parameters were analyzed pre-treatment and 1 month after completion of treatment. There was no dose limiting toxicity with IP SRL172 although there was greater toxicity at the highest dose (n=13). There were six out of 16 partial responses (37.5%). Haemato-immunological parameters, measured in seven patients pre and post-therapy, revealed that response rate correlated with a decrease in platelet count and there was an increase in activation of natural killer cells and a decrease in the percentage of IL-4 producing T cells in all tested patients post-treatment. SRL172 can be given safely into tumour deposits and the pleural cavity in patients with malignant mesothelioma and we have established the dose for phase II testing." @default.
• W2018087077 created "2016-06-24" @default.
• W2018087077 creator A5001503641 @default.
• W2018087077 creator A5009844374 @default.
• W2018087077 creator A5013257739 @default.
• W2018087077 creator A5018293998 @default.
• W2018087077 creator A5035383163 @default.
• W2018087077 creator A5043512230 @default.
• W2018087077 creator A5050696925 @default.
• W2018087077 creator A5056591355 @default.
• W2018087077 creator A5064706934 @default.
• W2018087077 creator A5079327745 @default.
• W2018087077 creator A5082873668 @default.
• W2018087077 date "2002-02-01" @default.
• W2018087077 modified "2023-10-18" @default.
• W2018087077 title "Clinical and immunological assessment of Mycobacterium vaccae (SRL172) with chemotherapy in patients with malignant mesothelioma" @default.
• W2018087077 cites W1481705756 @default.
• W2018087077 cites W1539485765 @default.
• W2018087077 cites W1869777220 @default.
• W2018087077 cites W1897113776 @default.
• W2018087077 cites W1948574410 @default.
• W2018087077 cites W1960348144 @default.
• W2018087077 cites W1976428603 @default.
• W2018087077 cites W1976535486 @default.
• W2018087077 cites W1988156363 @default.
• W2018087077 cites W1992334190 @default.
• W2018087077 cites W2004872189 @default.
• W2018087077 cites W2040291293 @default.
• W2018087077 cites W2055459491 @default.
• W2018087077 cites W2077248800 @default.
• W2018087077 cites W2078431529 @default.
• W2018087077 cites W2083919796 @default.
• W2018087077 cites W2085527849 @default.
• W2018087077 cites W2101834873 @default.
• W2018087077 cites W2129026847 @default.
• W2018087077 cites W2139248078 @default.
• W2018087077 cites W2150689799 @default.
• W2018087077 cites W2160096495 @default.
• W2018087077 cites W2163456861 @default.
• W2018087077 cites W2223722125 @default.
• W2018087077 cites W2332618327 @default.
• W2018087077 cites W4229686403 @default.
• W2018087077 doi "https://doi.org/10.1038/sj.bjc.6600063" @default.
• W2018087077 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2375208" @default.
• W2018087077 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11875694" @default.
• W2018087077 hasPublicationYear "2002" @default.
• W2018087077 type Work @default.
• W2018087077 sameAs 2018087077 @default.
• W2018087077 citedByCount "20" @default.
• W2018087077 countsByYear W20180870772012 @default.
• W2018087077 countsByYear W20180870772020 @default.
• W2018087077 crossrefType "journal-article" @default.
• W2018087077 hasAuthorship W2018087077A5001503641 @default.
• W2018087077 hasAuthorship W2018087077A5009844374 @default.
• W2018087077 hasAuthorship W2018087077A5013257739 @default.
• W2018087077 hasAuthorship W2018087077A5018293998 @default.
• W2018087077 hasAuthorship W2018087077A5035383163 @default.
• W2018087077 hasAuthorship W2018087077A5043512230 @default.
• W2018087077 hasAuthorship W2018087077A5050696925 @default.
• W2018087077 hasAuthorship W2018087077A5056591355 @default.
• W2018087077 hasAuthorship W2018087077A5064706934 @default.
• W2018087077 hasAuthorship W2018087077A5079327745 @default.
• W2018087077 hasAuthorship W2018087077A5082873668 @default.
• W2018087077 hasBestOaLocation W20180870771 @default.
• W2018087077 hasConcept C126322002 @default.
• W2018087077 hasConcept C141071460 @default.
• W2018087077 hasConcept C142724271 @default.
• W2018087077 hasConcept C203014093 @default.
• W2018087077 hasConcept C2776694085 @default.
• W2018087077 hasConcept C2777132456 @default.
• W2018087077 hasConcept C2777407522 @default.
• W2018087077 hasConcept C2778239845 @default.
• W2018087077 hasConcept C2779338040 @default.
• W2018087077 hasConcept C29730261 @default.
• W2018087077 hasConcept C71924100 @default.
• W2018087077 hasConcept C90924648 @default.
• W2018087077 hasConceptScore W2018087077C126322002 @default.
• W2018087077 hasConceptScore W2018087077C141071460 @default.
• W2018087077 hasConceptScore W2018087077C142724271 @default.
• W2018087077 hasConceptScore W2018087077C203014093 @default.
• W2018087077 hasConceptScore W2018087077C2776694085 @default.
• W2018087077 hasConceptScore W2018087077C2777132456 @default.
• W2018087077 hasConceptScore W2018087077C2777407522 @default.
• W2018087077 hasConceptScore W2018087077C2778239845 @default.
• W2018087077 hasConceptScore W2018087077C2779338040 @default.
• W2018087077 hasConceptScore W2018087077C29730261 @default.
• W2018087077 hasConceptScore W2018087077C71924100 @default.
• W2018087077 hasConceptScore W2018087077C90924648 @default.
• W2018087077 hasIssue "3" @default.
• W2018087077 hasLocation W20180870771 @default.
• W2018087077 hasLocation W20180870772 @default.
• W2018087077 hasLocation W20180870773 @default.
• W2018087077 hasLocation W20180870774 @default.
• W2018087077 hasOpenAccess W2018087077 @default.
• W2018087077 hasPrimaryLocation W20180870771 @default.
• W2018087077 hasRelatedWork W1519773982 @default.
• W2018087077 hasRelatedWork W1965964706 @default.
• W2018087077 hasRelatedWork W2064538515 @default.

• next