FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018087357> ?p ?o ?g. }

• W2018087357 abstract "Cholangiocarcinomas (CCA) paradoxically express the death ligand TRAIL and thus, are dependent on effective survival signals to circumvent apoptosis. Hedgehog signalling exerts major survival signals in CCA by regulating serine/threonine kinase polo-like kinase (PLK)2. We here aimed to examine the role of PLK1/2/3 expression for CCA tumour biology.We employed CCA samples from 73 patients and human HUCCT-1/Mz-CHA1/KMCH-1 CCA cells. Immunohistochemistry for PLK1/2/3 was performed using tissue microarrays from representative tumour areas.PLK1/2/3-immunoreactive cancer cells were present in most of the CCA samples. However, only PLK1 and especially PLK3 were expressed in higher amounts within CCA cells as compared to normal liver. Given that fibroblast growth factor (FGF) can induce PLK3 expression and also is present in CCA, we examined the effect of FGF on PLK3 in vitro. Indeed, rhFGF rapidly increased PLK3 mRNA expression all three CCA cell lines giving an explanation for the abundant PLK3 presence in the tissue samples. Clinicopathologically, PLK3 expression was associated with decreased tumour cell migration and lymph/blood vessel infiltration whereas higher levels of PLK1 were correlated with larger tumour sizes. Moreover, strong PLK3 expression was associated with prolonged overall survival.The results suggest that PLK3 predominantly is expressed in CCA cells and that high PLK3 expression correlates with prolonged overall survival. These observations might have implications for prognosis prediction of human CCA as well as the potential therapeutic use of polo-like kinase inhibitors (i.e., PLK1/2 specifity)." @default.
• W2018087357 created "2016-06-24" @default.
• W2018087357 creator A5000055216 @default.
• W2018087357 creator A5001703227 @default.
• W2018087357 creator A5002473571 @default.
• W2018087357 creator A5026279422 @default.
• W2018087357 creator A5030335749 @default.
• W2018087357 creator A5036726873 @default.
• W2018087357 creator A5041417663 @default.
• W2018087357 creator A5042438955 @default.
• W2018087357 creator A5052731204 @default.
• W2018087357 creator A5061830141 @default.
• W2018087357 creator A5071899214 @default.
• W2018087357 creator A5075896349 @default.
• W2018087357 creator A5082971086 @default.
• W2018087357 creator A5083921106 @default.
• W2018087357 date "2015-04-10" @default.
• W2018087357 modified "2023-10-18" @default.
• W2018087357 title "Polo-like kinase 3 is associated with improved overall survival in cholangiocarcinoma" @default.
• W2018087357 cites W1586027123 @default.
• W2018087357 cites W1968438075 @default.
• W2018087357 cites W1968672126 @default.
• W2018087357 cites W1971936302 @default.
• W2018087357 cites W2003997716 @default.
• W2018087357 cites W2007242949 @default.
• W2018087357 cites W2012962601 @default.
• W2018087357 cites W2025540821 @default.
• W2018087357 cites W2028700227 @default.
• W2018087357 cites W2035515971 @default.
• W2018087357 cites W2037874673 @default.
• W2018087357 cites W2038951216 @default.
• W2018087357 cites W2048802787 @default.
• W2018087357 cites W2062038681 @default.
• W2018087357 cites W2062809449 @default.
• W2018087357 cites W2071416644 @default.
• W2018087357 cites W2072992526 @default.
• W2018087357 cites W2082503761 @default.
• W2018087357 cites W2095046027 @default.
• W2018087357 cites W2114135705 @default.
• W2018087357 cites W2139320422 @default.
• W2018087357 cites W2163486957 @default.
• W2018087357 cites W2169281418 @default.
• W2018087357 cites W2307798789 @default.
• W2018087357 cites W2332605220 @default.
• W2018087357 cites W4211025847 @default.
• W2018087357 doi "https://doi.org/10.1111/liv.12839" @default.
• W2018087357 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25818805" @default.
• W2018087357 hasPublicationYear "2015" @default.
• W2018087357 type Work @default.
• W2018087357 sameAs 2018087357 @default.
• W2018087357 citedByCount "7" @default.
• W2018087357 countsByYear W20180873572016 @default.
• W2018087357 countsByYear W20180873572017 @default.
• W2018087357 countsByYear W20180873572018 @default.
• W2018087357 countsByYear W20180873572019 @default.
• W2018087357 countsByYear W20180873572021 @default.
• W2018087357 crossrefType "journal-article" @default.
• W2018087357 hasAuthorship W2018087357A5000055216 @default.
• W2018087357 hasAuthorship W2018087357A5001703227 @default.
• W2018087357 hasAuthorship W2018087357A5002473571 @default.
• W2018087357 hasAuthorship W2018087357A5026279422 @default.
• W2018087357 hasAuthorship W2018087357A5030335749 @default.
• W2018087357 hasAuthorship W2018087357A5036726873 @default.
• W2018087357 hasAuthorship W2018087357A5041417663 @default.
• W2018087357 hasAuthorship W2018087357A5042438955 @default.
• W2018087357 hasAuthorship W2018087357A5052731204 @default.
• W2018087357 hasAuthorship W2018087357A5061830141 @default.
• W2018087357 hasAuthorship W2018087357A5071899214 @default.
• W2018087357 hasAuthorship W2018087357A5075896349 @default.
• W2018087357 hasAuthorship W2018087357A5082971086 @default.
• W2018087357 hasAuthorship W2018087357A5083921106 @default.
• W2018087357 hasConcept C121608353 @default.
• W2018087357 hasConcept C146276462 @default.
• W2018087357 hasConcept C184235292 @default.
• W2018087357 hasConcept C190283241 @default.
• W2018087357 hasConcept C193270364 @default.
• W2018087357 hasConcept C203014093 @default.
• W2018087357 hasConcept C204232928 @default.
• W2018087357 hasConcept C29537977 @default.
• W2018087357 hasConcept C502942594 @default.
• W2018087357 hasConcept C54355233 @default.
• W2018087357 hasConcept C84815855 @default.
• W2018087357 hasConcept C86803240 @default.
• W2018087357 hasConcept C95444343 @default.
• W2018087357 hasConcept C96232424 @default.
• W2018087357 hasConceptScore W2018087357C121608353 @default.
• W2018087357 hasConceptScore W2018087357C146276462 @default.
• W2018087357 hasConceptScore W2018087357C184235292 @default.
• W2018087357 hasConceptScore W2018087357C190283241 @default.
• W2018087357 hasConceptScore W2018087357C193270364 @default.
• W2018087357 hasConceptScore W2018087357C203014093 @default.
• W2018087357 hasConceptScore W2018087357C204232928 @default.
• W2018087357 hasConceptScore W2018087357C29537977 @default.
• W2018087357 hasConceptScore W2018087357C502942594 @default.
• W2018087357 hasConceptScore W2018087357C54355233 @default.
• W2018087357 hasConceptScore W2018087357C84815855 @default.
• W2018087357 hasConceptScore W2018087357C86803240 @default.
• W2018087357 hasConceptScore W2018087357C95444343 @default.
• W2018087357 hasConceptScore W2018087357C96232424 @default.
• W2018087357 hasLocation W20180873571 @default.

• next