FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018090737> ?p ?o ?g. }

• W2018090737 endingPage "630" @default.
• W2018090737 startingPage "625" @default.
• W2018090737 abstract "Essential hypertension is a complex, multifactorial, polygenic disease in which the underlying genetic components remain unknown. Glutathione S-transferase (GST) enzyme is involved in detoxification of reactive oxygen species. This study aimed to investigate GSTM1 and GSTT1 gene polymorphisms in Egyptian essential hypertensive patients and their relationship with oxidative stress-related parameters.The study included 40 newly-diagnosed, untreated, essential hypertensive patients and 40 normotensive subjects. Plasma levels of malondialdehyde (MDA), and nitrate/nitrite and erythrocyte reduced glutathione (GSH), activities of catalase (CAT), superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and glutathione S-transferase (GST) were measured. Genotyping for GSTM1 and GSTT1 was performed.The frequency of GSTM1+ve/GSTT1+ve in hypertensives (5%) was lower than in normotensives (37.5%).The frequency of GSTM1-ve/GSTT1-ve was elevated in hypertensives (35%) as compared to normotensives (7.5%). Plasma MDA was higher and nitrate/nitrite was lower in hypertensives than in normotensives. Erythrocyte GSH, activities of CAT, SOD, GSH-Px, and GST of hypertensives were lower than normotensives. Moreover, GST activity was lower in subjects with GSTM1-ve/GSTT1-ve than in those with GSTM1+ve/GSTT1+ve. In hypertensives, both systolic and diastolic blood pressures were negatively correlated with activities of CAT, GSH-Px, and GST.GSTM1-ve/GSTT1-ve is a potential genetic factor to predict development of essential hypertension and permit early therapeutic intervention. The significant association between blood pressure and oxidative stress-related parameters indicates the pathogenic role of oxidative stress in hypertension. Antioxidants could be useful in the management of essential hypertension to prevent progressive deterioration and target organ damage however, further studies involving long-term clinical trials may help to assess the efficacy of these therapeutic agents." @default.
• W2018090737 created "2016-06-24" @default.
• W2018090737 creator A5029770014 @default.
• W2018090737 creator A5077990108 @default.
• W2018090737 creator A5086216632 @default.
• W2018090737 date "2009-10-01" @default.
• W2018090737 modified "2023-10-16" @default.
• W2018090737 title "The role of glutathione S- transferase M1 and T1 gene polymorphisms and oxidative stress-related parameters in Egyptian patients with essential hypertension" @default.
• W2018090737 cites W1528363123 @default.
• W2018090737 cites W1581414347 @default.
• W2018090737 cites W1750764013 @default.
• W2018090737 cites W1975410323 @default.
• W2018090737 cites W1975781920 @default.
• W2018090737 cites W1976346227 @default.
• W2018090737 cites W1976763513 @default.
• W2018090737 cites W1977229794 @default.
• W2018090737 cites W1984439610 @default.
• W2018090737 cites W1989480537 @default.
• W2018090737 cites W1998288051 @default.
• W2018090737 cites W2004173410 @default.
• W2018090737 cites W2004301150 @default.
• W2018090737 cites W2005311517 @default.
• W2018090737 cites W2007263773 @default.
• W2018090737 cites W2009771629 @default.
• W2018090737 cites W2012574221 @default.
• W2018090737 cites W2013480805 @default.
• W2018090737 cites W2030498112 @default.
• W2018090737 cites W2032724281 @default.
• W2018090737 cites W2040560754 @default.
• W2018090737 cites W2041592339 @default.
• W2018090737 cites W2043006337 @default.
• W2018090737 cites W2062786004 @default.
• W2018090737 cites W2069060792 @default.
• W2018090737 cites W2072552003 @default.
• W2018090737 cites W2078593792 @default.
• W2018090737 cites W2079580148 @default.
• W2018090737 cites W2082880363 @default.
• W2018090737 cites W2087443530 @default.
• W2018090737 cites W2096795975 @default.
• W2018090737 cites W2099273954 @default.
• W2018090737 cites W2101181611 @default.
• W2018090737 cites W2112726636 @default.
• W2018090737 cites W2122886157 @default.
• W2018090737 cites W2131410124 @default.
• W2018090737 cites W2131551885 @default.
• W2018090737 cites W2137194544 @default.
• W2018090737 cites W2155536801 @default.
• W2018090737 cites W2156121263 @default.
• W2018090737 cites W2157552205 @default.
• W2018090737 cites W2159172002 @default.
• W2018090737 cites W2160269969 @default.
• W2018090737 cites W2168975002 @default.
• W2018090737 cites W2335398010 @default.
• W2018090737 cites W2419199177 @default.
• W2018090737 cites W4238581030 @default.
• W2018090737 cites W969915667 @default.
• W2018090737 doi "https://doi.org/10.1016/j.ejim.2009.06.003" @default.
• W2018090737 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19782926" @default.
• W2018090737 hasPublicationYear "2009" @default.
• W2018090737 type Work @default.
• W2018090737 sameAs 2018090737 @default.
• W2018090737 citedByCount "50" @default.
• W2018090737 countsByYear W20180907372012 @default.
• W2018090737 countsByYear W20180907372013 @default.
• W2018090737 countsByYear W20180907372014 @default.
• W2018090737 countsByYear W20180907372015 @default.
• W2018090737 countsByYear W20180907372016 @default.
• W2018090737 countsByYear W20180907372017 @default.
• W2018090737 countsByYear W20180907372018 @default.
• W2018090737 countsByYear W20180907372019 @default.
• W2018090737 countsByYear W20180907372020 @default.
• W2018090737 countsByYear W20180907372021 @default.
• W2018090737 countsByYear W20180907372022 @default.
• W2018090737 crossrefType "journal-article" @default.
• W2018090737 hasAuthorship W2018090737A5029770014 @default.
• W2018090737 hasAuthorship W2018090737A5077990108 @default.
• W2018090737 hasAuthorship W2018090737A5086216632 @default.
• W2018090737 hasConcept C126322002 @default.
• W2018090737 hasConcept C134018914 @default.
• W2018090737 hasConcept C181199279 @default.
• W2018090737 hasConcept C2775838275 @default.
• W2018090737 hasConcept C2776151105 @default.
• W2018090737 hasConcept C2776907368 @default.
• W2018090737 hasConcept C2777097880 @default.
• W2018090737 hasConcept C2778401633 @default.
• W2018090737 hasConcept C2778760513 @default.
• W2018090737 hasConcept C48349386 @default.
• W2018090737 hasConcept C538909803 @default.
• W2018090737 hasConcept C55493867 @default.
• W2018090737 hasConcept C71924100 @default.
• W2018090737 hasConcept C84393581 @default.
• W2018090737 hasConcept C86803240 @default.
• W2018090737 hasConceptScore W2018090737C126322002 @default.
• W2018090737 hasConceptScore W2018090737C134018914 @default.
• W2018090737 hasConceptScore W2018090737C181199279 @default.
• W2018090737 hasConceptScore W2018090737C2775838275 @default.
• W2018090737 hasConceptScore W2018090737C2776151105 @default.
• W2018090737 hasConceptScore W2018090737C2776907368 @default.

• next