FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018092226> ?p ?o ?g. }

• W2018092226 endingPage "455" @default.
• W2018092226 startingPage "449" @default.
• W2018092226 abstract "Phosphorylation of the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (Pol II) regulates transcription cycle and coordinates recruitment of RNA processing factors and chromatin regulators. Recently, we reported the identification of human PCIF1 as a novel protein that directly binds to the phosphorylated CTD via its WW domain, which is highly homologous to the WW domain of human peptidylprolyl isomerase Pin1. Although PCIF1 has been shown to associate with phosphorylated Pol II, functional consequence of the interaction remains unclear. Here we further characterized the cytological, structural, and functional properties of human PCIF1. Immunofluorescence microscopy revealed that endogenous PCIF1 was colocalized with the phosphorylated Pol II and the transcription elongation factor DSIF in the cell nucleus. We also found that PCIF1 WW domain inhibits the CTD phosphatase activity of SCP1 in vitro. By examining the effect of either PCIF1 overexpression or knockdown on the transactivation of reporter gene expression by various transcriptional activation domains, we found that PCIF1 significantly repressed the transactivation depend on its CTD binding ability. These data suggest that PCIF1 modulates phosphorylation status of the CTD and negatively regulates gene expression by Pol II." @default.
• W2018092226 created "2016-06-24" @default.
• W2018092226 creator A5001488039 @default.
• W2018092226 creator A5006246664 @default.
• W2018092226 creator A5043670681 @default.
• W2018092226 creator A5052168818 @default.
• W2018092226 creator A5070289282 @default.
• W2018092226 creator A5082138461 @default.
• W2018092226 date "2008-05-01" @default.
• W2018092226 modified "2023-10-03" @default.
• W2018092226 title "Human phosphorylated CTD-interacting protein, PCIF1, negatively modulates gene expression by RNA polymerase II" @default.
• W2018092226 cites W1986427733 @default.
• W2018092226 cites W2013562830 @default.
• W2018092226 cites W2017216357 @default.
• W2018092226 cites W2022936085 @default.
• W2018092226 cites W2045959839 @default.
• W2018092226 cites W2050590451 @default.
• W2018092226 cites W2059023146 @default.
• W2018092226 cites W2068399313 @default.
• W2018092226 cites W2070603335 @default.
• W2018092226 cites W2072836045 @default.
• W2018092226 cites W2078367368 @default.
• W2018092226 cites W2126730534 @default.
• W2018092226 cites W2133938268 @default.
• W2018092226 cites W2140448223 @default.
• W2018092226 cites W2148917483 @default.
• W2018092226 cites W2163753548 @default.
• W2018092226 cites W2168696636 @default.
• W2018092226 cites W2171171901 @default.
• W2018092226 doi "https://doi.org/10.1016/j.bbrc.2008.02.042" @default.
• W2018092226 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18294453" @default.
• W2018092226 hasPublicationYear "2008" @default.
• W2018092226 type Work @default.
• W2018092226 sameAs 2018092226 @default.
• W2018092226 citedByCount "28" @default.
• W2018092226 countsByYear W20180922262012 @default.
• W2018092226 countsByYear W20180922262013 @default.
• W2018092226 countsByYear W20180922262014 @default.
• W2018092226 countsByYear W20180922262015 @default.
• W2018092226 countsByYear W20180922262016 @default.
• W2018092226 countsByYear W20180922262018 @default.
• W2018092226 countsByYear W20180922262019 @default.
• W2018092226 countsByYear W20180922262020 @default.
• W2018092226 countsByYear W20180922262021 @default.
• W2018092226 countsByYear W20180922262022 @default.
• W2018092226 countsByYear W20180922262023 @default.
• W2018092226 crossrefType "journal-article" @default.
• W2018092226 hasAuthorship W2018092226A5001488039 @default.
• W2018092226 hasAuthorship W2018092226A5006246664 @default.
• W2018092226 hasAuthorship W2018092226A5043670681 @default.
• W2018092226 hasAuthorship W2018092226A5052168818 @default.
• W2018092226 hasAuthorship W2018092226A5070289282 @default.
• W2018092226 hasAuthorship W2018092226A5082138461 @default.
• W2018092226 hasConcept C101762097 @default.
• W2018092226 hasConcept C104317684 @default.
• W2018092226 hasConcept C111368507 @default.
• W2018092226 hasConcept C11960822 @default.
• W2018092226 hasConcept C125533998 @default.
• W2018092226 hasConcept C127313418 @default.
• W2018092226 hasConcept C1292079 @default.
• W2018092226 hasConcept C138885662 @default.
• W2018092226 hasConcept C150194340 @default.
• W2018092226 hasConcept C153911025 @default.
• W2018092226 hasConcept C173396325 @default.
• W2018092226 hasConcept C179926584 @default.
• W2018092226 hasConcept C196117886 @default.
• W2018092226 hasConcept C41895202 @default.
• W2018092226 hasConcept C55493867 @default.
• W2018092226 hasConcept C64350747 @default.
• W2018092226 hasConcept C83640560 @default.
• W2018092226 hasConcept C86803240 @default.
• W2018092226 hasConcept C95444343 @default.
• W2018092226 hasConceptScore W2018092226C101762097 @default.
• W2018092226 hasConceptScore W2018092226C104317684 @default.
• W2018092226 hasConceptScore W2018092226C111368507 @default.
• W2018092226 hasConceptScore W2018092226C11960822 @default.
• W2018092226 hasConceptScore W2018092226C125533998 @default.
• W2018092226 hasConceptScore W2018092226C127313418 @default.
• W2018092226 hasConceptScore W2018092226C1292079 @default.
• W2018092226 hasConceptScore W2018092226C138885662 @default.
• W2018092226 hasConceptScore W2018092226C150194340 @default.
• W2018092226 hasConceptScore W2018092226C153911025 @default.
• W2018092226 hasConceptScore W2018092226C173396325 @default.
• W2018092226 hasConceptScore W2018092226C179926584 @default.
• W2018092226 hasConceptScore W2018092226C196117886 @default.
• W2018092226 hasConceptScore W2018092226C41895202 @default.
• W2018092226 hasConceptScore W2018092226C55493867 @default.
• W2018092226 hasConceptScore W2018092226C64350747 @default.
• W2018092226 hasConceptScore W2018092226C83640560 @default.
• W2018092226 hasConceptScore W2018092226C86803240 @default.
• W2018092226 hasConceptScore W2018092226C95444343 @default.
• W2018092226 hasFunder F4320309785 @default.
• W2018092226 hasFunder F4320309809 @default.
• W2018092226 hasFunder F4320310389 @default.
• W2018092226 hasFunder F4320320912 @default.
• W2018092226 hasIssue "2" @default.
• W2018092226 hasLocation W20180922261 @default.
• W2018092226 hasLocation W20180922262 @default.

• next