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• W2018093068 abstract "SUMMARY We have previously reported that genetic immunization with Tc 13Tul antigen of Trypanosoma cruzi , the aetiological agent of Chagas' disease, triggers harmful effects and non-protective immune responses. In order to confirm the role of Tc 13 antigens during T. cruzi infection, herein we studied the humoral and cellular immune responses to the Tc 13Tul molecule and its EPKSA C-terminal portion in BALB/c T. cruzi -infected mice or mice immunized with recombinant Tc 13Tul. Analysis of the antibody response showed that B-cell epitopes that stimulate a sustained IgM production along the infection and high levels of IgG in the acute phase are mainly located at the Tc 13 N- and C-terminal domains, respectively. DTH assays showed that T-cell epitopes are mainly at the Tc 13 N-terminal segment and that they do not elicit an efficient memory response. Recombinant Tc 13Tul did not induce IFN-γ secretion in either infected or immunized mice. However, a putative CD8+ T c13Tul-derived peptide was found to elicit IFN-γ production in chronically infected animals. Immunization with recombinant Tc 13Tul did not induce pathology in tissues and neither did it protect against the infection. Our results show that in the outcome of T. cruzi infection the Tc 13 family protein mainly triggers non-protective immune responses." @default.
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• W2018093068 date "2007-11-09" @default.
• W2018093068 modified "2023-10-15" @default.
• W2018093068 title "Evaluation of immune responses raised against<i>Tc</i>13 antigens of<i>Trypanosoma cruzi</i>in the outcome of murine experimental infection" @default.
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• W2018093068 doi "https://doi.org/10.1017/s0031182007003873" @default.
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