FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018093175> ?p ?o ?g. }

• W2018093175 endingPage "162" @default.
• W2018093175 startingPage "156" @default.
• W2018093175 abstract "Levetiracetam (LEV), a new anticonvulsant agent primarily used to treat epilepsy, has been used in pain treatment but the cellular mechanism of this action remains unclear. This study aimed to investigate effects of LEV on the excitability and membrane depolarization-induced calcium signaling in isolated rat sensory neurons using the whole-cell patch clamp and fura 2–based ratiometric Ca2+-imaging techniques. Dorsal root ganglia (DRG) were excised from neonatal rats, and cultured following enzymatic and mechanical dissociation. Under current clamp conditions, acute application of LEV (30 µM, 100 µM and 300 µM) significantly increased input resistance and caused the membrane to hyperpolarize from resting membrane potential in a dose-dependent manner. Reversal potentials of action potential (AP) after hyperpolarising amplitudes were shifted to more negative, toward to potassium equilibrium potentials, after application of LEV. It also caused a decrease in number of APs in neurons fired multiple APs in response to prolonged depolarization. Fura-2 fluorescence Ca2+ imaging protocols revealed that HiK+ (30 mM)-induced intracellular free Ca2+ ([Ca2+]i) was inhibited to 97.8 ± 4.6% (n = 17), 92.6 ± 4.8% (n = 17, p < 0.01) and 89.1 ± 5.1% (n = 18, p < 0.01) after application of 30 µM, 100 µM and 300 µM LEV (respectively), without any significant effect on basal levels of [Ca2+]i. This is the first evidence for the effect of LEV on the excitability of rat sensory neurons through an effect which might involve activation of potassium channels and inhibition of entry of Ca2+, providing new insights for cellular mechanism(s) of LEV in pain treatment modalities." @default.
• W2018093175 created "2016-06-24" @default.
• W2018093175 creator A5044320853 @default.
• W2018093175 creator A5054598270 @default.
• W2018093175 date "2012-04-05" @default.
• W2018093175 modified "2023-10-18" @default.
• W2018093175 title "Modulation of action potential and calcium signaling by levetiracetam in rat sensory neurons" @default.
• W2018093175 cites W1490982528 @default.
• W2018093175 cites W1895549562 @default.
• W2018093175 cites W1966384426 @default.
• W2018093175 cites W1966689015 @default.
• W2018093175 cites W1970154519 @default.
• W2018093175 cites W1978408389 @default.
• W2018093175 cites W1979298238 @default.
• W2018093175 cites W1981294852 @default.
• W2018093175 cites W1984661583 @default.
• W2018093175 cites W2008356917 @default.
• W2018093175 cites W2009502669 @default.
• W2018093175 cites W2011785379 @default.
• W2018093175 cites W2019170259 @default.
• W2018093175 cites W2023448340 @default.
• W2018093175 cites W2027022038 @default.
• W2018093175 cites W2043800976 @default.
• W2018093175 cites W2044492675 @default.
• W2018093175 cites W2053020884 @default.
• W2018093175 cites W2055676578 @default.
• W2018093175 cites W2065214055 @default.
• W2018093175 cites W2075046805 @default.
• W2018093175 cites W2076371406 @default.
• W2018093175 cites W2087139947 @default.
• W2018093175 cites W2092918915 @default.
• W2018093175 cites W2113600098 @default.
• W2018093175 cites W2125655338 @default.
• W2018093175 cites W2128490730 @default.
• W2018093175 cites W2143736855 @default.
• W2018093175 cites W2155626680 @default.
• W2018093175 cites W4232990896 @default.
• W2018093175 cites W4252893597 @default.
• W2018093175 doi "https://doi.org/10.3109/10799893.2012.672993" @default.
• W2018093175 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22475033" @default.
• W2018093175 hasPublicationYear "2012" @default.
• W2018093175 type Work @default.
• W2018093175 sameAs 2018093175 @default.
• W2018093175 citedByCount "5" @default.
• W2018093175 countsByYear W20180931752014 @default.
• W2018093175 countsByYear W20180931752015 @default.
• W2018093175 countsByYear W20180931752017 @default.
• W2018093175 countsByYear W20180931752019 @default.
• W2018093175 crossrefType "journal-article" @default.
• W2018093175 hasAuthorship W2018093175A5044320853 @default.
• W2018093175 hasAuthorship W2018093175A5054598270 @default.
• W2018093175 hasConcept C12554922 @default.
• W2018093175 hasConcept C126322002 @default.
• W2018093175 hasConcept C147944092 @default.
• W2018093175 hasConcept C169760540 @default.
• W2018093175 hasConcept C181911157 @default.
• W2018093175 hasConcept C185263204 @default.
• W2018093175 hasConcept C185592680 @default.
• W2018093175 hasConcept C2776032975 @default.
• W2018093175 hasConcept C2777151030 @default.
• W2018093175 hasConcept C4141045 @default.
• W2018093175 hasConcept C519063684 @default.
• W2018093175 hasConcept C71924100 @default.
• W2018093175 hasConcept C86803240 @default.
• W2018093175 hasConcept C94487597 @default.
• W2018093175 hasConcept C98274493 @default.
• W2018093175 hasConceptScore W2018093175C12554922 @default.
• W2018093175 hasConceptScore W2018093175C126322002 @default.
• W2018093175 hasConceptScore W2018093175C147944092 @default.
• W2018093175 hasConceptScore W2018093175C169760540 @default.
• W2018093175 hasConceptScore W2018093175C181911157 @default.
• W2018093175 hasConceptScore W2018093175C185263204 @default.
• W2018093175 hasConceptScore W2018093175C185592680 @default.
• W2018093175 hasConceptScore W2018093175C2776032975 @default.
• W2018093175 hasConceptScore W2018093175C2777151030 @default.
• W2018093175 hasConceptScore W2018093175C4141045 @default.
• W2018093175 hasConceptScore W2018093175C519063684 @default.
• W2018093175 hasConceptScore W2018093175C71924100 @default.
• W2018093175 hasConceptScore W2018093175C86803240 @default.
• W2018093175 hasConceptScore W2018093175C94487597 @default.
• W2018093175 hasConceptScore W2018093175C98274493 @default.
• W2018093175 hasIssue "3" @default.
• W2018093175 hasLocation W20180931751 @default.
• W2018093175 hasLocation W20180931752 @default.
• W2018093175 hasOpenAccess W2018093175 @default.
• W2018093175 hasPrimaryLocation W20180931751 @default.
• W2018093175 hasRelatedWork W1967539632 @default.
• W2018093175 hasRelatedWork W1969097312 @default.
• W2018093175 hasRelatedWork W1990054546 @default.
• W2018093175 hasRelatedWork W2013640811 @default.
• W2018093175 hasRelatedWork W2046510053 @default.
• W2018093175 hasRelatedWork W2048011947 @default.
• W2018093175 hasRelatedWork W2055830121 @default.
• W2018093175 hasRelatedWork W2061630254 @default.
• W2018093175 hasRelatedWork W2088281397 @default.
• W2018093175 hasRelatedWork W2417181054 @default.
• W2018093175 hasVolume "32" @default.
• W2018093175 isParatext "false" @default.

• next