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• W2018093809 abstract "While some intracellular bacterial and viral proteins secreted into host cell possess ubiquitin ligase (E3) activity for their profit, it has not been reported whether intracellular parasites secrete such molecules. We identified a gene that encodes a protein containing a secretory signal peptide and a RING finger domain in the intracellular protozoan parasite, Trypanosoma cruzi. This gene was specific to T. cruzi and was designated spring (secretory protein with RING finger domain). An in vitro ubiquitination assay showed that SPRING possessed E3 activity in a RING finger domain-dependent manner. SPRING could utilize human ubiquitin-activating enzymes (E2), UbcH5 and UbcH13. Although SPRING was found to be a secretory protein, the signal peptide-cleaved mature form of SPRING was localized in the nucleus of host cells, indicating that SPRING may function in the host cell nuclei. Yeast two-hybrid screening identified 52 putative SPRING interactors in HeLa cells, suggesting that SPRING affects the stability or function of a number of host proteins. Furthermore, a co-immunoprecipitation assay showed that breast cancer-associated protein 3 interacted with SPRING, as well as being ubiquitinated by SPRING in vitro. These findings are the first to show that this protozoan parasite secretes an ubiquitin ligase-related protein into host cells." @default.
• W2018093809 created "2016-06-24" @default.
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• W2018093809 creator A5075241995 @default.
• W2018093809 creator A5082343932 @default.
• W2018093809 date "2010-01-01" @default.
• W2018093809 modified "2023-09-25" @default.
• W2018093809 title "Secretory protein with RING finger domain (SPRING) specific to<i>Trypanosoma cruzi</i>is directed, as a ubiquitin ligase related protein, to the nucleus of host cells" @default.
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• W2018093809 doi "https://doi.org/10.1111/j.1462-5822.2009.01375.x" @default.
• W2018093809 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19702650" @default.
• W2018093809 hasPublicationYear "2010" @default.
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