Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018093826> ?p ?o ?g. }
- W2018093826 endingPage "42" @default.
- W2018093826 startingPage "37" @default.
- W2018093826 abstract "Antidepressant-like activity of folic acid in forced swimming test and in the tail suspension test was demonstrated previously by our group. In this study we investigated the involvement of N-methyl-d-aspartate (NMDA) receptors and l-arginine-nitric oxide (NO)-cyclic guanosine monophosphate pathway in its antidepressant-like effect in the forced swimming test in mice. The antidepressant-like effect of folic acid (10 nmol/site, i.c.v.) was prevented by the pretreatment of mice with NMDA (0.1 pmol/site, i.c.v.), l-arginine (750 mg/kg, i.p., substrate for nitric oxide synthase), S-nitroso-N-acetyl-penicillamine (SNAP, 25 microg/site, i.c.v, a NO donor) or sildenafil (5 mg/kg, i.p., phosphodiesterase 5 inhibitor). The administration of 7-nitroindazole (25 and 50 mg/kg, i.p., a specific neuronal nitric oxide synthase (nNOS) inhibitor) or methylene blue (20 mg/kg, i.p., direct inhibitor of both nitric oxide synthase and soluble guanylate cyclase) in combination with a sub-effective dose of folic acid (1 nmol/site, i.c.v.) reduced the immobility time in the FST as compared with either drug alone. Together the results suggest that the antidepressant-like effect of folic acid in the forced swimming test is dependent on an inhibition of either NMDA receptors or NO and cGMP synthesis." @default.
- W2018093826 created "2016-06-24" @default.
- W2018093826 creator A5031221345 @default.
- W2018093826 creator A5035554922 @default.
- W2018093826 creator A5036826819 @default.
- W2018093826 creator A5045654416 @default.
- W2018093826 creator A5088301232 @default.
- W2018093826 date "2008-11-01" @default.
- W2018093826 modified "2023-09-25" @default.
- W2018093826 title "Antidepressant-like effect of folic acid: Involvement of NMDA receptors and l-arginine-nitric oxide-cyclic guanosine monophosphate pathway" @default.
- W2018093826 cites W109954717 @default.
- W2018093826 cites W1979420282 @default.
- W2018093826 cites W1979475203 @default.
- W2018093826 cites W1983899648 @default.
- W2018093826 cites W1987798935 @default.
- W2018093826 cites W1991412103 @default.
- W2018093826 cites W1995418515 @default.
- W2018093826 cites W1997091817 @default.
- W2018093826 cites W1999218050 @default.
- W2018093826 cites W2003742114 @default.
- W2018093826 cites W2004838884 @default.
- W2018093826 cites W2006014108 @default.
- W2018093826 cites W2017546704 @default.
- W2018093826 cites W2018283685 @default.
- W2018093826 cites W2019465027 @default.
- W2018093826 cites W2019823288 @default.
- W2018093826 cites W2022793207 @default.
- W2018093826 cites W2023928627 @default.
- W2018093826 cites W2024882862 @default.
- W2018093826 cites W2029329379 @default.
- W2018093826 cites W2029981740 @default.
- W2018093826 cites W2042825148 @default.
- W2018093826 cites W2052822734 @default.
- W2018093826 cites W2055602534 @default.
- W2018093826 cites W2056609212 @default.
- W2018093826 cites W2060006930 @default.
- W2018093826 cites W2071293996 @default.
- W2018093826 cites W2071625364 @default.
- W2018093826 cites W2088577867 @default.
- W2018093826 cites W2109334244 @default.
- W2018093826 cites W2123187562 @default.
- W2018093826 cites W2123593284 @default.
- W2018093826 cites W2131812309 @default.
- W2018093826 cites W2135075842 @default.
- W2018093826 cites W2142786903 @default.
- W2018093826 cites W2166389885 @default.
- W2018093826 cites W2332800117 @default.
- W2018093826 cites W4241790271 @default.
- W2018093826 cites W4251925032 @default.
- W2018093826 cites W4376595753 @default.
- W2018093826 doi "https://doi.org/10.1016/j.ejphar.2008.08.033" @default.
- W2018093826 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18789921" @default.
- W2018093826 hasPublicationYear "2008" @default.
- W2018093826 type Work @default.
- W2018093826 sameAs 2018093826 @default.
- W2018093826 citedByCount "66" @default.
- W2018093826 countsByYear W20180938262012 @default.
- W2018093826 countsByYear W20180938262013 @default.
- W2018093826 countsByYear W20180938262014 @default.
- W2018093826 countsByYear W20180938262015 @default.
- W2018093826 countsByYear W20180938262016 @default.
- W2018093826 countsByYear W20180938262017 @default.
- W2018093826 countsByYear W20180938262018 @default.
- W2018093826 countsByYear W20180938262019 @default.
- W2018093826 countsByYear W20180938262020 @default.
- W2018093826 countsByYear W20180938262021 @default.
- W2018093826 crossrefType "journal-article" @default.
- W2018093826 hasAuthorship W2018093826A5031221345 @default.
- W2018093826 hasAuthorship W2018093826A5035554922 @default.
- W2018093826 hasAuthorship W2018093826A5036826819 @default.
- W2018093826 hasAuthorship W2018093826A5045654416 @default.
- W2018093826 hasAuthorship W2018093826A5088301232 @default.
- W2018093826 hasConcept C126322002 @default.
- W2018093826 hasConcept C134018914 @default.
- W2018093826 hasConcept C170493617 @default.
- W2018093826 hasConcept C178790620 @default.
- W2018093826 hasConcept C185592680 @default.
- W2018093826 hasConcept C2776766087 @default.
- W2018093826 hasConcept C2777622882 @default.
- W2018093826 hasConcept C2777995097 @default.
- W2018093826 hasConcept C2780994212 @default.
- W2018093826 hasConcept C519581460 @default.
- W2018093826 hasConcept C55493867 @default.
- W2018093826 hasConcept C67018056 @default.
- W2018093826 hasConcept C71924100 @default.
- W2018093826 hasConcept C98274493 @default.
- W2018093826 hasConceptScore W2018093826C126322002 @default.
- W2018093826 hasConceptScore W2018093826C134018914 @default.
- W2018093826 hasConceptScore W2018093826C170493617 @default.
- W2018093826 hasConceptScore W2018093826C178790620 @default.
- W2018093826 hasConceptScore W2018093826C185592680 @default.
- W2018093826 hasConceptScore W2018093826C2776766087 @default.
- W2018093826 hasConceptScore W2018093826C2777622882 @default.
- W2018093826 hasConceptScore W2018093826C2777995097 @default.
- W2018093826 hasConceptScore W2018093826C2780994212 @default.
- W2018093826 hasConceptScore W2018093826C519581460 @default.
- W2018093826 hasConceptScore W2018093826C55493867 @default.
- W2018093826 hasConceptScore W2018093826C67018056 @default.