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Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018093953> ?p ?o ?g. }

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• W2018093953 abstract "O-(2-[18F]fluoroethyl)-l-tyrosine ([18F]FET) is one of the first 18F-labeled amino acids for imaging amino acid metabolism in tumors. This tracer overcomes the disadvantages of [18F]fluorodeoxyglucose, [18F]FDG, and [11C]methionine, [11C]MET. Nevertheless, the various synthetic methods providing 18F[FET] exhibit a big disadvantage concerning the necessity of two purification steps during the synthesis including HPLC purification, which causes difficulties in the automation, moderate yields, and long synthesis times >60 min. A new approach for the synthesis of [18F]FET is developed starting from 2-bromoethyl triflate as precursor. After optimization of the synthesis parameters including the distillation step of [18F]-FCH2CH2Br combined with the final purification of [18F]FET using a simple solid phase extraction instead of an HPLC run the synthesis [18F]FET could be significantly simplified, shortened, and improved. The radiochemical yield (RCY) was about 45% (not decay corrected and calculated relative to [18F]F− activity that was delivered from the cyclotron). Synthesis time was only 35 min from the end of bombardment (EOB) and the radiochemical purity was >99% at the end of synthesis (EOS). Thus, this simplified synthesis for [18F]FET offers a very good option for routine clinical use." @default.
• W2018093953 created "2016-06-24" @default.
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• W2018093953 date "2009-11-01" @default.
• W2018093953 modified "2023-09-30" @default.
• W2018093953 title "New approach for the synthesis of [18F]fluoroethyltyrosine for cancer imaging: Simple, fast, and high yielding automated synthesis" @default.
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• W2018093953 doi "https://doi.org/10.1016/j.bmc.2009.09.029" @default.
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