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- W2018094089 abstract "Cerebrospinal fluid (CSF) is the only body fluid in direct contact with the brain and thus is a potential source of biomarkers. Furthermore, CSF serves as a medium of endocrine signaling and contains a multitude of regulatory peptides. A combined study of the peptidome and proteome of CSF or any other body fluid has not been reported previously. We report confident identification in CSF of 563 peptide products derived from 91 precursor proteins as well as a high confidence CSF proteome of 798 proteins. For the CSF peptidome, we use high accuracy mass spectrometry (MS) for MS and MS/MS modes, allowing unambiguous identification of neuropeptides. Combination of the peptidome and proteome data suggests that enzymatic processing of membrane proteins causes release of their extracellular parts into CSF. The CSF proteome has only partial overlap with the plasma proteome, thus it is produced locally rather than deriving from plasma. Our work offers insights into CSF composition and origin." @default.
- W2018094089 created "2016-06-24" @default.
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- W2018094089 date "2008-01-01" @default.
- W2018094089 modified "2023-10-16" @default.
- W2018094089 title "Integrated Analysis of the Cerebrospinal Fluid Peptidome and Proteome" @default.
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- W2018094089 doi "https://doi.org/10.1021/pr070501k" @default.
- W2018094089 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18052119" @default.
- W2018094089 hasPublicationYear "2008" @default.
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