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- W2018094774 abstract "Abstract Direct evidence for aflatoxin-chromatin interaction was obtained using fluorescence quenching as a measure of the interaction. Interaction of aflatoxin B1 with components of chromatin increased in the following order: nonhistone residue, DNA, histone, histone-free chromatin, and intact chromatin. Fluorescence change due to interaction of aflatoxin B1 with various complexes of chromatin constituents was not significantly different from that obtained with DNA. Association of aflatoxin B1 with chromatin components was very weak whereas that with reconstituted deoxyribonucleoprotein (consisting of histone, nonhistone residue, and DNA) and with native chromatin was strong as shown by increase in fluorescence polarization of aflatoxin. Such data suggest the importance of structural integrity of chromatin in the binding with aflatoxin. Interaction of aflatoxin G1 with chromatin was less than that of aflatoxin B1." @default.
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- W2018094774 date "1976-06-01" @default.
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- W2018094774 title "Binding of aflatoxins B1 and G1 to rat liver chromatin" @default.
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- W2018094774 doi "https://doi.org/10.1016/0041-008x(76)90229-5" @default.
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