Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018094787> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2018094787 endingPage "S202" @default.
- W2018094787 startingPage "S198" @default.
- W2018094787 abstract "It has been suggested that tryptophan 563 is sandwiched between residues R562 and A582 in Bruton's agammaglobulinemia tyrosine kinase (Btk). Mutations of the surrounding residues have been shown to cause X-linked agammaglobulinemia. Substitutions R562P and A582V were noticed to have impaired kinase activity. However, based on Western blot analysis, the mutant proteins were expressed at normal levels. Molecular modeling of the kinase domain has previously indicated that these residues presumably govern the position of the W563 side chain, which is thought to interact with the catalytic loop. W563 is inside the molecule and too far away from the catalytic center to interact directly with the substrate or cofactors. To prove these model-based conclusions, a conservative substitution with phenylalanine for W563 was made, and the resultant mutant lacked kinase activity. These results confirm our previous assumption that the side chain of W563, invariant in protein tyrosine kinases, is crucial for Btk kinase activity. Mutations in the surrounding residues seem to inactivate Btk by affecting the location of W563." @default.
- W2018094787 created "2016-06-24" @default.
- W2018094787 creator A5014392818 @default.
- W2018094787 creator A5020878971 @default.
- W2018094787 creator A5033021345 @default.
- W2018094787 creator A5037433972 @default.
- W2018094787 creator A5062205173 @default.
- W2018094787 date "1995-09-01" @default.
- W2018094787 modified "2023-10-01" @default.
- W2018094787 title "Structural basis for X-linked agammaglobulinemia (XLA): mutations at interacting Btk residues R562, W563, and A582" @default.
- W2018094787 cites W1942192923 @default.
- W2018094787 cites W1988803183 @default.
- W2018094787 cites W1994816231 @default.
- W2018094787 cites W1994954884 @default.
- W2018094787 cites W2014347276 @default.
- W2018094787 cites W2020442337 @default.
- W2018094787 cites W2024881920 @default.
- W2018094787 cites W2050965695 @default.
- W2018094787 cites W2051435930 @default.
- W2018094787 cites W2052221882 @default.
- W2018094787 cites W2064208630 @default.
- W2018094787 cites W2067405360 @default.
- W2018094787 cites W2075758658 @default.
- W2018094787 cites W2089577767 @default.
- W2018094787 cites W2100034730 @default.
- W2018094787 cites W2105733675 @default.
- W2018094787 cites W2113764179 @default.
- W2018094787 cites W2141736955 @default.
- W2018094787 cites W2170865316 @default.
- W2018094787 cites W2324316160 @default.
- W2018094787 cites W2340425144 @default.
- W2018094787 cites W4237874187 @default.
- W2018094787 doi "https://doi.org/10.1016/s0090-1229(95)90216-3" @default.
- W2018094787 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7554468" @default.
- W2018094787 hasPublicationYear "1995" @default.
- W2018094787 type Work @default.
- W2018094787 sameAs 2018094787 @default.
- W2018094787 citedByCount "11" @default.
- W2018094787 countsByYear W20180947872015 @default.
- W2018094787 countsByYear W20180947872020 @default.
- W2018094787 countsByYear W20180947872022 @default.
- W2018094787 countsByYear W20180947872023 @default.
- W2018094787 crossrefType "journal-article" @default.
- W2018094787 hasAuthorship W2018094787A5014392818 @default.
- W2018094787 hasAuthorship W2018094787A5020878971 @default.
- W2018094787 hasAuthorship W2018094787A5033021345 @default.
- W2018094787 hasAuthorship W2018094787A5037433972 @default.
- W2018094787 hasAuthorship W2018094787A5062205173 @default.
- W2018094787 hasConcept C104317684 @default.
- W2018094787 hasConcept C143065580 @default.
- W2018094787 hasConcept C184235292 @default.
- W2018094787 hasConcept C185592680 @default.
- W2018094787 hasConcept C2776165026 @default.
- W2018094787 hasConcept C2779528874 @default.
- W2018094787 hasConcept C2781338088 @default.
- W2018094787 hasConcept C32619005 @default.
- W2018094787 hasConcept C42362537 @default.
- W2018094787 hasConcept C501734568 @default.
- W2018094787 hasConcept C55493867 @default.
- W2018094787 hasConcept C62478195 @default.
- W2018094787 hasConcept C86803240 @default.
- W2018094787 hasConcept C90059517 @default.
- W2018094787 hasConceptScore W2018094787C104317684 @default.
- W2018094787 hasConceptScore W2018094787C143065580 @default.
- W2018094787 hasConceptScore W2018094787C184235292 @default.
- W2018094787 hasConceptScore W2018094787C185592680 @default.
- W2018094787 hasConceptScore W2018094787C2776165026 @default.
- W2018094787 hasConceptScore W2018094787C2779528874 @default.
- W2018094787 hasConceptScore W2018094787C2781338088 @default.
- W2018094787 hasConceptScore W2018094787C32619005 @default.
- W2018094787 hasConceptScore W2018094787C42362537 @default.
- W2018094787 hasConceptScore W2018094787C501734568 @default.
- W2018094787 hasConceptScore W2018094787C55493867 @default.
- W2018094787 hasConceptScore W2018094787C62478195 @default.
- W2018094787 hasConceptScore W2018094787C86803240 @default.
- W2018094787 hasConceptScore W2018094787C90059517 @default.
- W2018094787 hasIssue "3" @default.
- W2018094787 hasLocation W20180947871 @default.
- W2018094787 hasLocation W20180947872 @default.
- W2018094787 hasOpenAccess W2018094787 @default.
- W2018094787 hasPrimaryLocation W20180947871 @default.
- W2018094787 hasRelatedWork W1865034106 @default.
- W2018094787 hasRelatedWork W1963905553 @default.
- W2018094787 hasRelatedWork W2018094787 @default.
- W2018094787 hasRelatedWork W2070829838 @default.
- W2018094787 hasRelatedWork W2086878398 @default.
- W2018094787 hasRelatedWork W2141736955 @default.
- W2018094787 hasRelatedWork W2147053903 @default.
- W2018094787 hasRelatedWork W2161904432 @default.
- W2018094787 hasRelatedWork W2170865316 @default.
- W2018094787 hasRelatedWork W3048137895 @default.
- W2018094787 hasVolume "76" @default.
- W2018094787 isParatext "false" @default.
- W2018094787 isRetracted "false" @default.
- W2018094787 magId "2018094787" @default.
- W2018094787 workType "article" @default.