Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018094931> ?p ?o ?g. }
- W2018094931 endingPage "6187" @default.
- W2018094931 startingPage "6173" @default.
- W2018094931 abstract "A novel series of symmetrical ureas of [(7-amino(2-naphthyl))sulfonyl]phenylamines were designed, synthesized, and tested for their ability to increase glucose transport in mouse 3T3-L1 adipocytes, a surrogate readout for activation of the insulin receptor (IR) tyrosine kinase (IRTK). A structure−activity relationship was established that indicated glucose transport activity was dependent on the presence of two acidic functionalities, two sulfonamide linkages, and a central urea or 2-imidazolidinone core. Compound 30 was identified as a potent and selective IRTK activator. At low concentrations, 30 was able to increase the tyrosine phosphorylation of the IR stimulated by submaximal insulin. At higher concentrations, 30 was able to increase tyrosine the phosphorylation levels of the IR in the absence of insulin. When administered intraperitoneally (ip) and orally (po), 30 improved glucose tolerance in hypoinsulinemic, streptozotocin-treated rats. These data provide pharmacological validation that small molecule IRTK activators represent a potential new class of antidiabetic agents." @default.
- W2018094931 created "2016-06-24" @default.
- W2018094931 creator A5008292386 @default.
- W2018094931 creator A5010591993 @default.
- W2018094931 creator A5020771325 @default.
- W2018094931 creator A5033226354 @default.
- W2018094931 creator A5039905412 @default.
- W2018094931 creator A5040239819 @default.
- W2018094931 creator A5044476470 @default.
- W2018094931 creator A5046537097 @default.
- W2018094931 creator A5058424890 @default.
- W2018094931 creator A5060034489 @default.
- W2018094931 creator A5069535967 @default.
- W2018094931 creator A5077275410 @default.
- W2018094931 creator A5079343876 @default.
- W2018094931 creator A5090551785 @default.
- W2018094931 creator A5091189105 @default.
- W2018094931 date "2008-09-13" @default.
- W2018094931 modified "2023-09-26" @default.
- W2018094931 title "Design, Synthesis, and Structure−Activity Relationships of Novel Insulin Receptor Tyrosine Kinase Activators" @default.
- W2018094931 cites W1495740709 @default.
- W2018094931 cites W1523721174 @default.
- W2018094931 cites W1526978170 @default.
- W2018094931 cites W1541030808 @default.
- W2018094931 cites W1975588287 @default.
- W2018094931 cites W1977268754 @default.
- W2018094931 cites W1980186342 @default.
- W2018094931 cites W1998818672 @default.
- W2018094931 cites W2019202316 @default.
- W2018094931 cites W2020267609 @default.
- W2018094931 cites W2021976026 @default.
- W2018094931 cites W2028212562 @default.
- W2018094931 cites W2034884103 @default.
- W2018094931 cites W2049702067 @default.
- W2018094931 cites W2053443443 @default.
- W2018094931 cites W2067096633 @default.
- W2018094931 cites W2068227412 @default.
- W2018094931 cites W2073171519 @default.
- W2018094931 cites W2078374645 @default.
- W2018094931 cites W2096773810 @default.
- W2018094931 cites W2098990050 @default.
- W2018094931 cites W2102643655 @default.
- W2018094931 cites W2109303114 @default.
- W2018094931 cites W2113328569 @default.
- W2018094931 cites W2115970342 @default.
- W2018094931 cites W2120774442 @default.
- W2018094931 cites W2128023946 @default.
- W2018094931 cites W2132519313 @default.
- W2018094931 cites W2138100045 @default.
- W2018094931 cites W2138226825 @default.
- W2018094931 cites W2138508948 @default.
- W2018094931 cites W2143345681 @default.
- W2018094931 cites W2156604743 @default.
- W2018094931 cites W2167442923 @default.
- W2018094931 cites W2171030070 @default.
- W2018094931 cites W2315982688 @default.
- W2018094931 cites W2324473093 @default.
- W2018094931 cites W2325322971 @default.
- W2018094931 cites W2950999242 @default.
- W2018094931 doi "https://doi.org/10.1021/jm800600v" @default.
- W2018094931 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18788731" @default.
- W2018094931 hasPublicationYear "2008" @default.
- W2018094931 type Work @default.
- W2018094931 sameAs 2018094931 @default.
- W2018094931 citedByCount "14" @default.
- W2018094931 countsByYear W20180949312012 @default.
- W2018094931 countsByYear W20180949312013 @default.
- W2018094931 countsByYear W20180949312015 @default.
- W2018094931 countsByYear W20180949312017 @default.
- W2018094931 countsByYear W20180949312018 @default.
- W2018094931 countsByYear W20180949312019 @default.
- W2018094931 countsByYear W20180949312020 @default.
- W2018094931 countsByYear W20180949312023 @default.
- W2018094931 crossrefType "journal-article" @default.
- W2018094931 hasAuthorship W2018094931A5008292386 @default.
- W2018094931 hasAuthorship W2018094931A5010591993 @default.
- W2018094931 hasAuthorship W2018094931A5020771325 @default.
- W2018094931 hasAuthorship W2018094931A5033226354 @default.
- W2018094931 hasAuthorship W2018094931A5039905412 @default.
- W2018094931 hasAuthorship W2018094931A5040239819 @default.
- W2018094931 hasAuthorship W2018094931A5044476470 @default.
- W2018094931 hasAuthorship W2018094931A5046537097 @default.
- W2018094931 hasAuthorship W2018094931A5058424890 @default.
- W2018094931 hasAuthorship W2018094931A5060034489 @default.
- W2018094931 hasAuthorship W2018094931A5069535967 @default.
- W2018094931 hasAuthorship W2018094931A5077275410 @default.
- W2018094931 hasAuthorship W2018094931A5079343876 @default.
- W2018094931 hasAuthorship W2018094931A5090551785 @default.
- W2018094931 hasAuthorship W2018094931A5091189105 @default.
- W2018094931 hasConcept C101544691 @default.
- W2018094931 hasConcept C112446052 @default.
- W2018094931 hasConcept C11960822 @default.
- W2018094931 hasConcept C126322002 @default.
- W2018094931 hasConcept C134018914 @default.
- W2018094931 hasConcept C170493617 @default.
- W2018094931 hasConcept C185592680 @default.
- W2018094931 hasConcept C2776165026 @default.
- W2018094931 hasConcept C2777391703 @default.