FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018096295> ?p ?o ?g. }

• W2018096295 endingPage "6980" @default.
• W2018096295 startingPage "6976" @default.
• W2018096295 abstract "The ionic current underlying the upstroke of axonal action potentials is carried by rapidly activating, voltage-dependent Na+ channels. Termination of the action potential is mediated in part by the rapid inactivation of these Na+ channels. We previously demonstrated that an influx of Na+ plays a critical role in the cascade leading to irreversible anoxic injury in central nervous system white matter. We speculated that a noninactivating Na+ conductance mediates this pathological Na+ influx and persists at depolarized membrane potentials as seen in anoxic axons. In the present study we measured the resting compound membrane potential of rat optic nerves using a modified grease-gap technique. Application of tetrodotoxin (2 microM) to resting nerves ([K+]o = 3 mM) or to nerves depolarized by 15 or 40 mM K+ resulted in hyperpolarizing shifts of membrane potential. We interpret these shifts as evidence for a persistent, noninactivating Na+ conductance. This conductance is present at rest and persists in nerves depolarized sufficiently to abolish classical transient Na+ currents. PK/PNa ratios were estimated at 35.5, 23.2, and 88 in 3 mM, 15 mM, and 40 mM K+, respectively. We suggest that this noninactivating Na+ conductance may provide an inward pathway for Na+ ions, necessary for the operation of Na+, K(+)-ATPase. Under pathological conditions, such as anoxia, this conductance is the likely route of Na+ influx, which causes damaging Ca2+ entry through reverse operation of the Na(+)-Ca2+ exchanger. The presence of this conductance in white matter axons may provide a therapeutic opportunity for diseases such as stroke and spinal cord injury." @default.
• W2018096295 created "2016-06-24" @default.
• W2018096295 creator A5002957653 @default.
• W2018096295 creator A5043231922 @default.
• W2018096295 creator A5054101427 @default.
• W2018096295 creator A5088300774 @default.
• W2018096295 date "1993-08-01" @default.
• W2018096295 modified "2023-09-24" @default.
• W2018096295 title "Noninactivating, tetrodotoxin-sensitive Na+ conductance in rat optic nerve axons." @default.
• W2018096295 cites W1967071366 @default.
• W2018096295 cites W1974842872 @default.
• W2018096295 cites W1976544104 @default.
• W2018096295 cites W1986442576 @default.
• W2018096295 cites W1992746395 @default.
• W2018096295 cites W1994340740 @default.
• W2018096295 cites W1995773085 @default.
• W2018096295 cites W2001522791 @default.
• W2018096295 cites W2005941970 @default.
• W2018096295 cites W2012677577 @default.
• W2018096295 cites W2014783850 @default.
• W2018096295 cites W2021706887 @default.
• W2018096295 cites W2031785864 @default.
• W2018096295 cites W2041894106 @default.
• W2018096295 cites W2049724011 @default.
• W2018096295 cites W2049901372 @default.
• W2018096295 cites W2052284056 @default.
• W2018096295 cites W2064848556 @default.
• W2018096295 cites W2064948391 @default.
• W2018096295 cites W2070353624 @default.
• W2018096295 cites W2070390515 @default.
• W2018096295 cites W2079173805 @default.
• W2018096295 cites W2087180713 @default.
• W2018096295 cites W2093166155 @default.
• W2018096295 cites W2113448091 @default.
• W2018096295 cites W2131921751 @default.
• W2018096295 cites W2137911312 @default.
• W2018096295 cites W2152016695 @default.
• W2018096295 cites W2153412362 @default.
• W2018096295 cites W2155063413 @default.
• W2018096295 cites W2155837486 @default.
• W2018096295 cites W2166852953 @default.
• W2018096295 cites W2171915535 @default.
• W2018096295 cites W2219473100 @default.
• W2018096295 cites W2311237560 @default.
• W2018096295 cites W2395858733 @default.
• W2018096295 cites W2400317664 @default.
• W2018096295 cites W2411938571 @default.
• W2018096295 doi "https://doi.org/10.1073/pnas.90.15.6976" @default.
• W2018096295 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/47058" @default.
• W2018096295 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8394004" @default.
• W2018096295 hasPublicationYear "1993" @default.
• W2018096295 type Work @default.
• W2018096295 sameAs 2018096295 @default.
• W2018096295 citedByCount "202" @default.
• W2018096295 countsByYear W20180962952012 @default.
• W2018096295 countsByYear W20180962952013 @default.
• W2018096295 countsByYear W20180962952014 @default.
• W2018096295 countsByYear W20180962952015 @default.
• W2018096295 countsByYear W20180962952016 @default.
• W2018096295 countsByYear W20180962952017 @default.
• W2018096295 countsByYear W20180962952018 @default.
• W2018096295 countsByYear W20180962952019 @default.
• W2018096295 countsByYear W20180962952021 @default.
• W2018096295 countsByYear W20180962952022 @default.
• W2018096295 crossrefType "journal-article" @default.
• W2018096295 hasAuthorship W2018096295A5002957653 @default.
• W2018096295 hasAuthorship W2018096295A5043231922 @default.
• W2018096295 hasAuthorship W2018096295A5054101427 @default.
• W2018096295 hasAuthorship W2018096295A5088300774 @default.
• W2018096295 hasBestOaLocation W20180962951 @default.
• W2018096295 hasConcept C105702510 @default.
• W2018096295 hasConcept C121332964 @default.
• W2018096295 hasConcept C121932024 @default.
• W2018096295 hasConcept C12554922 @default.
• W2018096295 hasConcept C158494493 @default.
• W2018096295 hasConcept C169760540 @default.
• W2018096295 hasConcept C181911157 @default.
• W2018096295 hasConcept C185592680 @default.
• W2018096295 hasConcept C26873012 @default.
• W2018096295 hasConcept C2776741303 @default.
• W2018096295 hasConcept C4141045 @default.
• W2018096295 hasConcept C86803240 @default.
• W2018096295 hasConceptScore W2018096295C105702510 @default.
• W2018096295 hasConceptScore W2018096295C121332964 @default.
• W2018096295 hasConceptScore W2018096295C121932024 @default.
• W2018096295 hasConceptScore W2018096295C12554922 @default.
• W2018096295 hasConceptScore W2018096295C158494493 @default.
• W2018096295 hasConceptScore W2018096295C169760540 @default.
• W2018096295 hasConceptScore W2018096295C181911157 @default.
• W2018096295 hasConceptScore W2018096295C185592680 @default.
• W2018096295 hasConceptScore W2018096295C26873012 @default.
• W2018096295 hasConceptScore W2018096295C2776741303 @default.
• W2018096295 hasConceptScore W2018096295C4141045 @default.
• W2018096295 hasConceptScore W2018096295C86803240 @default.
• W2018096295 hasIssue "15" @default.
• W2018096295 hasLocation W20180962951 @default.
• W2018096295 hasLocation W20180962952 @default.
• W2018096295 hasLocation W20180962953 @default.

• next