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• W2018097723 endingPage "e1004527" @default.
• W2018097723 startingPage "e1004527" @default.
• W2018097723 abstract "In order to be transmitted, a pathogen must first successfully colonize and multiply within a host. Ecological principles can be applied to study host-pathogen interactions to predict transmission dynamics. Little is known about the population biology of Salmonella during persistent infection. To define Salmonella enterica serovar Typhimurium population structure in this context, 129SvJ mice were oral gavaged with a mixture of eight wild-type isogenic tagged Salmonella (WITS) strains. Distinct subpopulations arose within intestinal and systemic tissues after 35 days, and clonal expansion of the cecal and colonic subpopulation was responsible for increases in Salmonella fecal shedding. A co-infection system utilizing differentially marked isogenic strains was developed in which each mouse received one strain orally and the other systemically by intraperitoneal (IP) injection. Co-infections demonstrated that the intestinal subpopulation exerted intraspecies priority effects by excluding systemic S. Typhimurium from colonizing an extracellular niche within the cecum and colon. Importantly, the systemic strain was excluded from these distal gut sites and was not transmitted to naïve hosts. In addition, S. Typhimurium required hydrogenase, an enzyme that mediates acquisition of hydrogen from the gut microbiota, during the first week of infection to exert priority effects in the gut. Thus, early inhibitory priority effects are facilitated by the acquisition of nutrients, which allow S. Typhimurium to successfully compete for a nutritional niche in the distal gut. We also show that intraspecies colonization resistance is maintained by Salmonella Pathogenicity Islands SPI1 and SPI2 during persistent distal gut infection. Thus, important virulence effectors not only modulate interactions with host cells, but are crucial for Salmonella colonization of an extracellular intestinal niche and thereby also shape intraspecies dynamics. We conclude that priority effects and intraspecies competition for colonization niches in the distal gut control Salmonella population assembly and transmission." @default.
• W2018097723 created "2016-06-24" @default.
• W2018097723 creator A5031762888 @default.
• W2018097723 creator A5088184958 @default.
• W2018097723 date "2014-12-04" @default.
• W2018097723 modified "2023-10-16" @default.
• W2018097723 title "Intraspecies Competition for Niches in the Distal Gut Dictate Transmission during Persistent Salmonella Infection" @default.
• W2018097723 cites W107598738 @default.
• W2018097723 cites W1519644081 @default.
• W2018097723 cites W1871667078 @default.
• W2018097723 cites W1912958903 @default.
• W2018097723 cites W1966419853 @default.
• W2018097723 cites W19687057 @default.
• W2018097723 cites W1973852640 @default.
• W2018097723 cites W1975913397 @default.
• W2018097723 cites W1976763516 @default.
• W2018097723 cites W1979886015 @default.
• W2018097723 cites W1987691266 @default.
• W2018097723 cites W1991860284 @default.
• W2018097723 cites W1992149604 @default.
• W2018097723 cites W1994896583 @default.
• W2018097723 cites W1995143038 @default.
• W2018097723 cites W199831152 @default.
• W2018097723 cites W2006655672 @default.
• W2018097723 cites W2008758799 @default.
• W2018097723 cites W2014494685 @default.
• W2018097723 cites W2015077069 @default.
• W2018097723 cites W2026283215 @default.
• W2018097723 cites W2026950156 @default.
• W2018097723 cites W2028063089 @default.
• W2018097723 cites W2028321468 @default.
• W2018097723 cites W2029066977 @default.
• W2018097723 cites W2029765376 @default.
• W2018097723 cites W2039808886 @default.
• W2018097723 cites W2040676946 @default.
• W2018097723 cites W2042835068 @default.
• W2018097723 cites W2043891142 @default.
• W2018097723 cites W2044514249 @default.
• W2018097723 cites W2045953344 @default.
• W2018097723 cites W2048070542 @default.
• W2018097723 cites W2056432511 @default.
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• W2018097723 cites W2058686178 @default.
• W2018097723 cites W2062624942 @default.
• W2018097723 cites W2064488801 @default.
• W2018097723 cites W2078143319 @default.
• W2018097723 cites W2078614595 @default.
• W2018097723 cites W2083717261 @default.
• W2018097723 cites W2084120324 @default.
• W2018097723 cites W2087109157 @default.
• W2018097723 cites W2087712997 @default.
• W2018097723 cites W2088533694 @default.
• W2018097723 cites W2097310134 @default.
• W2018097723 cites W2099291451 @default.
• W2018097723 cites W2102868720 @default.
• W2018097723 cites W2106808528 @default.
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• W2018097723 cites W2116163716 @default.
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• W2018097723 cites W2123484637 @default.
• W2018097723 cites W2124519481 @default.
• W2018097723 cites W2125956343 @default.
• W2018097723 cites W2127697422 @default.
• W2018097723 cites W2128394626 @default.
• W2018097723 cites W2132530250 @default.
• W2018097723 cites W2133067224 @default.
• W2018097723 cites W2136660715 @default.
• W2018097723 cites W2138408086 @default.
• W2018097723 cites W2141311686 @default.
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• W2018097723 cites W2147618390 @default.
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• W2018097723 cites W2264634742 @default.
• W2018097723 cites W2400331685 @default.
• W2018097723 cites W2485881852 @default.
• W2018097723 cites W37142226 @default.
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• W2018097723 doi "https://doi.org/10.1371/journal.ppat.1004527" @default.
• W2018097723 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4256465" @default.
• W2018097723 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25474319" @default.
• W2018097723 hasPublicationYear "2014" @default.
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