FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018097791> ?p ?o ?g. }

• W2018097791 endingPage "125" @default.
• W2018097791 startingPage "115" @default.
• W2018097791 abstract "A population of interconnected neurons of the mammalian suprachiasmatic nuclei (SCN) controls circadian rhythms in physiological functions. In turn, a circadian rhythm of individual neurons is driven by intracellular processes, which via activation of specific membrane channels, produce circadian modulation of electrical firing rate. Yet the membrane target(s) of the cellular clock have remained enigmatic. Previously, subthreshold voltage-dependent cation (SVC) channels have been proposed as the membrane target of the cellular clock responsible for circadian modulation of the firing rate in SCN neurons. We tested this hypothesis with computational modeling based on experimental results from on-cell recording of SVC channel openings in acutely isolated SCN neurons and long-term continuous recording of activity from dispersed SCN neurons in a multielectrode array dish (MED). The model reproduced the circadian behavior if the number of SVC channels or their kinetics were modulated in accordance with protein concentration in a model of the intracellular clock (Scheper et al., 1999. J. Neurosci. 19, 40–47). Such modulation changed the average firing rate of the model neuron from zero (“subjective-night” silence) up to 18 Hz (“subjective-day” peak). Furthermore, the variability of interspike intervals (ISI) and the circadian pattern of firing rate (i.e. silence-to-activity ratio and shape of circadian peaks) are in reasonable agreement with experimental data obtained in dispersed SCN neurons in MED. These results suggest that the variability of ISI in intact SCN neurons is mostly due to stochastic single-channel openings, and that the circadian pattern of the firing rate is specified by threshold properties of dependence of the spontaneous firing rate on the number of single channels (R–N relationship). This plausible mathematical modeling supports the hypothesis that SVC channels could be a critical element in circadian modulation of firing rate in SCN neurons." @default.
• W2018097791 created "2016-06-24" @default.
• W2018097791 creator A5053640224 @default.
• W2018097791 creator A5059120253 @default.
• W2018097791 date "2010-07-01" @default.
• W2018097791 modified "2023-09-25" @default.
• W2018097791 title "Modeling the spontaneous activity in suprachiasmatic nucleus neurons: Role of cation single channels" @default.
• W2018097791 cites W1518019884 @default.
• W2018097791 cites W1608987350 @default.
• W2018097791 cites W1903780997 @default.
• W2018097791 cites W1964271393 @default.
• W2018097791 cites W1968306032 @default.
• W2018097791 cites W1970130379 @default.
• W2018097791 cites W1985940938 @default.
• W2018097791 cites W2008663982 @default.
• W2018097791 cites W2009308275 @default.
• W2018097791 cites W2010228562 @default.
• W2018097791 cites W2013204833 @default.
• W2018097791 cites W2013225862 @default.
• W2018097791 cites W2018738302 @default.
• W2018097791 cites W2020340826 @default.
• W2018097791 cites W2020551161 @default.
• W2018097791 cites W2027704011 @default.
• W2018097791 cites W2031223202 @default.
• W2018097791 cites W2033490561 @default.
• W2018097791 cites W2033917491 @default.
• W2018097791 cites W2045095925 @default.
• W2018097791 cites W2046577583 @default.
• W2018097791 cites W2047279254 @default.
• W2018097791 cites W2049281818 @default.
• W2018097791 cites W2052495259 @default.
• W2018097791 cites W2054219055 @default.
• W2018097791 cites W2062999298 @default.
• W2018097791 cites W2069293589 @default.
• W2018097791 cites W2070352474 @default.
• W2018097791 cites W2071471251 @default.
• W2018097791 cites W2072361295 @default.
• W2018097791 cites W2075459548 @default.
• W2018097791 cites W2082433800 @default.
• W2018097791 cites W2092147371 @default.
• W2018097791 cites W2093324929 @default.
• W2018097791 cites W2106686068 @default.
• W2018097791 cites W2111374626 @default.
• W2018097791 cites W2113674483 @default.
• W2018097791 cites W2113798065 @default.
• W2018097791 cites W2114683126 @default.
• W2018097791 cites W2115247238 @default.
• W2018097791 cites W2119644217 @default.
• W2018097791 cites W2124582837 @default.
• W2018097791 cites W2129086803 @default.
• W2018097791 cites W2144454171 @default.
• W2018097791 cites W2154420009 @default.
• W2018097791 cites W2164885103 @default.
• W2018097791 cites W2167652900 @default.
• W2018097791 cites W2239963466 @default.
• W2018097791 cites W2095828201 @default.
• W2018097791 doi "https://doi.org/10.1016/j.jtbi.2010.03.039" @default.
• W2018097791 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20362589" @default.
• W2018097791 hasPublicationYear "2010" @default.
• W2018097791 type Work @default.
• W2018097791 sameAs 2018097791 @default.
• W2018097791 citedByCount "7" @default.
• W2018097791 countsByYear W20180977912012 @default.
• W2018097791 countsByYear W20180977912015 @default.
• W2018097791 countsByYear W20180977912018 @default.
• W2018097791 countsByYear W20180977912023 @default.
• W2018097791 crossrefType "journal-article" @default.
• W2018097791 hasAuthorship W2018097791A5053640224 @default.
• W2018097791 hasAuthorship W2018097791A5059120253 @default.
• W2018097791 hasConcept C121446783 @default.
• W2018097791 hasConcept C12554922 @default.
• W2018097791 hasConcept C169760540 @default.
• W2018097791 hasConcept C181911157 @default.
• W2018097791 hasConcept C185592680 @default.
• W2018097791 hasConcept C2778794669 @default.
• W2018097791 hasConcept C2779317972 @default.
• W2018097791 hasConcept C2908647359 @default.
• W2018097791 hasConcept C38606739 @default.
• W2018097791 hasConcept C71924100 @default.
• W2018097791 hasConcept C86803240 @default.
• W2018097791 hasConcept C99454951 @default.
• W2018097791 hasConceptScore W2018097791C121446783 @default.
• W2018097791 hasConceptScore W2018097791C12554922 @default.
• W2018097791 hasConceptScore W2018097791C169760540 @default.
• W2018097791 hasConceptScore W2018097791C181911157 @default.
• W2018097791 hasConceptScore W2018097791C185592680 @default.
• W2018097791 hasConceptScore W2018097791C2778794669 @default.
• W2018097791 hasConceptScore W2018097791C2779317972 @default.
• W2018097791 hasConceptScore W2018097791C2908647359 @default.
• W2018097791 hasConceptScore W2018097791C38606739 @default.
• W2018097791 hasConceptScore W2018097791C71924100 @default.
• W2018097791 hasConceptScore W2018097791C86803240 @default.
• W2018097791 hasConceptScore W2018097791C99454951 @default.
• W2018097791 hasIssue "2" @default.
• W2018097791 hasLocation W20180977911 @default.
• W2018097791 hasLocation W20180977912 @default.
• W2018097791 hasOpenAccess W2018097791 @default.
• W2018097791 hasPrimaryLocation W20180977911 @default.

• next