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• W2018102932 endingPage "312" @default.
• W2018102932 startingPage "292" @default.
• W2018102932 abstract "We develop a statistical mechanical model for RNA/RNA complexes with both intramolecular and intermolecular interactions. As an application of the model, we compute the free energy landscapes, which give the full distribution for all the possible conformations, for U4/U6 and U2/U6 in major spliceosome and U4atac/U6atac and U12/U6atac in minor spliceosome. Different snRNA experiments found contrasting structures, our free energy landscape theory shows why these structures emerge and how they compete with each other. For yeast U2/U6, the model predicts that the two distinct experimental structures, the four-helix junction structure and the helix Ib-containing structure, can actually coexist and specifically compete with each other. In addition, the energy landscapes suggest possible mechanisms for the conformational switches in splicing. For instance, our calculation shows that coaxial stacking is essential for stabilizing the four-helix junction in yeast U2/U6. Therefore, inhibition of the coaxial stacking possibly by protein-binding may activate the conformational switch from the four-helix junction to the helix Ib-containing structure. Moreover, the change of the energy landscape shape gives information about the conformational changes. We find multiple (native-like and misfolded) intermediates formed through base-pairing rearrangements in snRNA complexes. For example, the unfolding of the U2/U6 undergoes a transition to a misfolded state which is functional, while in the unfolding of U12/U6atac, the functional helix Ib is found to be the last one to unfold and is thus the most stable structural component. Furthermore, the energy landscape gives the stabilities of all the possible (functional) intermediates and such information is directly related to splicing efficiency." @default.
• W2018102932 created "2016-06-24" @default.
• W2018102932 creator A5022452561 @default.
• W2018102932 creator A5035021352 @default.
• W2018102932 date "2006-03-01" @default.
• W2018102932 modified "2023-10-17" @default.
• W2018102932 title "Free Energy Landscapes of RNA/RNA Complexes: With Applications to snRNA Complexes in Spliceosomes" @default.
• W2018102932 cites W1545252215 @default.
• W2018102932 cites W1574643310 @default.
• W2018102932 cites W1642023497 @default.
• W2018102932 cites W1768733293 @default.
• W2018102932 cites W1831072099 @default.
• W2018102932 cites W1945061505 @default.
• W2018102932 cites W1967944402 @default.
• W2018102932 cites W1968072881 @default.
• W2018102932 cites W1968086656 @default.
• W2018102932 cites W1984116290 @default.
• W2018102932 cites W1984675364 @default.
• W2018102932 cites W1985991078 @default.
• W2018102932 cites W1988884185 @default.
• W2018102932 cites W1989835274 @default.
• W2018102932 cites W1990077091 @default.
• W2018102932 cites W1991251351 @default.
• W2018102932 cites W1993648028 @default.
• W2018102932 cites W1996948250 @default.
• W2018102932 cites W2001509514 @default.
• W2018102932 cites W2006253061 @default.
• W2018102932 cites W2009612178 @default.
• W2018102932 cites W2012067705 @default.
• W2018102932 cites W2014095962 @default.
• W2018102932 cites W2022916085 @default.
• W2018102932 cites W2025071510 @default.
• W2018102932 cites W2025388270 @default.
• W2018102932 cites W2035136477 @default.
• W2018102932 cites W2036755237 @default.
• W2018102932 cites W2036969473 @default.
• W2018102932 cites W2042820257 @default.
• W2018102932 cites W2043653977 @default.
• W2018102932 cites W2044245711 @default.
• W2018102932 cites W2051082289 @default.
• W2018102932 cites W2054010580 @default.
• W2018102932 cites W2056565971 @default.
• W2018102932 cites W2056617805 @default.
• W2018102932 cites W2057850636 @default.
• W2018102932 cites W2058059940 @default.
• W2018102932 cites W2059138972 @default.
• W2018102932 cites W2065262709 @default.
• W2018102932 cites W2067203238 @default.
• W2018102932 cites W2069504710 @default.
• W2018102932 cites W2071032973 @default.
• W2018102932 cites W2086253147 @default.
• W2018102932 cites W2086964032 @default.
• W2018102932 cites W2089960634 @default.
• W2018102932 cites W2093757673 @default.
• W2018102932 cites W2094253263 @default.
• W2018102932 cites W2096573498 @default.
• W2018102932 cites W2098219409 @default.
• W2018102932 cites W2098855506 @default.
• W2018102932 cites W2100895286 @default.
• W2018102932 cites W2103250001 @default.
• W2018102932 cites W2104216802 @default.
• W2018102932 cites W2104728352 @default.
• W2018102932 cites W2106087030 @default.
• W2018102932 cites W2110871443 @default.
• W2018102932 cites W2112333437 @default.
• W2018102932 cites W2113690897 @default.
• W2018102932 cites W2117435208 @default.
• W2018102932 cites W2118520828 @default.
• W2018102932 cites W2118666987 @default.
• W2018102932 cites W2119133259 @default.
• W2018102932 cites W2120200808 @default.
• W2018102932 cites W2120456037 @default.
• W2018102932 cites W2123695081 @default.
• W2018102932 cites W2124334253 @default.
• W2018102932 cites W2132505931 @default.
• W2018102932 cites W2135995702 @default.
• W2018102932 cites W2136645624 @default.
• W2018102932 cites W2138835510 @default.
• W2018102932 cites W2139793149 @default.
• W2018102932 cites W2141157874 @default.
• W2018102932 cites W2142776965 @default.
• W2018102932 cites W2144384550 @default.
• W2018102932 cites W2146760000 @default.
• W2018102932 cites W2149118168 @default.
• W2018102932 cites W2150764864 @default.
• W2018102932 cites W2153070849 @default.
• W2018102932 cites W2155544170 @default.
• W2018102932 cites W2158738287 @default.
• W2018102932 cites W2163199119 @default.
• W2018102932 cites W2165639228 @default.
• W2018102932 cites W2165890129 @default.
• W2018102932 cites W2167622305 @default.
• W2018102932 cites W2168602920 @default.
• W2018102932 cites W2171871148 @default.
• W2018102932 cites W4237655687 @default.
• W2018102932 doi "https://doi.org/10.1016/j.jmb.2005.12.014" @default.
• W2018102932 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2442757" @default.
• W2018102932 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16413034" @default.

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