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- W2018105468 abstract "Differentiation of mesenchymal stem cells (MSCs) is regulated by multivariate physical and chemical signals in a complicated microenvironment. In this study, polymerizable double bonds (GelMA) and osteo-inductive alendronate (Aln) (Aln-GelMA) were sequentially grafted onto gelatin molecules. The biocompatible hydrogels with defined stiffness in the range of 4-40 kPa were prepared by using polyethylene glycol diacrylate (PEGDA) as additional crosslinker. The Aln density was adjusted from 0 to 4 μM by controlling the ratio between the GelMA and Aln-GelMA. The combinational effects of stiffness and Aln density on osteogenic differentiation of MSCs were then studied in terms of ALP activity, collagen type I and osteocalcin expression, and calcium deposition. The results indicated that the stiffness and Aln density could synergistically improve the expression of all these osteogenesis markers. Their osteo-inductive effects are comparable to some extent, and high Aln density could be more effective than the stiffness." @default.
- W2018105468 created "2016-06-24" @default.
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- W2018105468 date "2015-06-01" @default.
- W2018105468 modified "2023-10-17" @default.
- W2018105468 title "Combinational effect of matrix elasticity and alendronate density on differentiation of rat mesenchymal stem cells" @default.
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- W2018105468 doi "https://doi.org/10.1016/j.actbio.2015.03.018" @default.
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