FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018109748> ?p ?o ?g. }

• W2018109748 endingPage "519" @default.
• W2018109748 startingPage "514" @default.
• W2018109748 abstract "The objective of this study was to quantify the changes in p53 and cyclin DI protein levels in different stages of human esophageal and gastric cardia carcinogenesis in a high-risk population in Henan, China. Immunoreactivity of p53, cyclin DI and proliferating-cell nuclear antigen (PCNA) was observed in the cell nuclei of esophageal and gastric cardia biopsies. The number of p53-immunostaining-positive cells was low in normal epithelia, slightly increased in basal-cell hyperplasia (BCH), markedly increased in dysplasia (DYS) (10-fold), and further increased in squamous-cell carcinoma (SCC) (40-fold). This pattern of change was similar to that of cell proliferation as indicated by PCNA immunostaining. On the other hand, the number of cyclin DI-immunostaining-positive cells did not increase from BCH to DYS, although a slight increase from DYS to SCC was noted. In the gastric cardia, again, the pattern of change of p53-positive cells in different stages of lesions paralleled the pattern of cell proliferation. The number of p53-positive cells was very low, much lower than that of PCNA-positive cells, in normal, chronic superficial gastritis (CSG) and chronic atrophic gastritis (CAG); therefore, the increase of p53-positive cells from CAG to DYS was more dramatic (100-fold). From DYS to adenocarcinoma (AC), the p53-positive and the PCNA-positive cells increased 4-fold. On the other hand, the number of cyclin DI-positive cells did not increase in pre-cancerous lesions, but increased slightly in AC. This study demonstrates that p53 protein accumulation increased with the progression of pre-cancerous lesions, especially in the genesis of dysplasia, both in the esophagus and in the gastric cardia. Our approach of quantitative immunohistochemistry sheds light on the mechanisms of genesis of esophageal and gastric-cardia cancers, which frequently occur together in many highincidence areas. © 1994 Wiley-Liss, Inc." @default.
• W2018109748 created "2016-06-24" @default.
• W2018109748 creator A5004901492 @default.
• W2018109748 creator A5022006549 @default.
• W2018109748 creator A5025062638 @default.
• W2018109748 creator A5047338113 @default.
• W2018109748 creator A5069987608 @default.
• W2018109748 creator A5079143963 @default.
• W2018109748 creator A5086188593 @default.
• W2018109748 creator A5090085904 @default.
• W2018109748 date "1994-11-15" @default.
• W2018109748 modified "2023-09-23" @default.
• W2018109748 title "Changes in p53 and cyclin D1 protein levels and cell proliferation in different stages of human esophageal and gastric-cardia carcinogenesis" @default.
• W2018109748 cites W1625189041 @default.
• W2018109748 cites W1671539212 @default.
• W2018109748 cites W1859397449 @default.
• W2018109748 cites W1969113661 @default.
• W2018109748 cites W1981841975 @default.
• W2018109748 cites W1992864942 @default.
• W2018109748 cites W1994082723 @default.
• W2018109748 cites W1999275729 @default.
• W2018109748 cites W2009986278 @default.
• W2018109748 cites W2016244517 @default.
• W2018109748 cites W2017978482 @default.
• W2018109748 cites W2032236714 @default.
• W2018109748 cites W2040687079 @default.
• W2018109748 cites W2065505484 @default.
• W2018109748 doi "https://doi.org/10.1002/ijc.2910590414" @default.
• W2018109748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7960222" @default.
• W2018109748 hasPublicationYear "1994" @default.
• W2018109748 type Work @default.
• W2018109748 sameAs 2018109748 @default.
• W2018109748 citedByCount "91" @default.
• W2018109748 countsByYear W20181097482012 @default.
• W2018109748 countsByYear W20181097482013 @default.
• W2018109748 countsByYear W20181097482014 @default.
• W2018109748 countsByYear W20181097482017 @default.
• W2018109748 countsByYear W20181097482018 @default.
• W2018109748 countsByYear W20181097482020 @default.
• W2018109748 countsByYear W20181097482021 @default.
• W2018109748 countsByYear W20181097482022 @default.
• W2018109748 crossrefType "journal-article" @default.
• W2018109748 hasAuthorship W2018109748A5004901492 @default.
• W2018109748 hasAuthorship W2018109748A5022006549 @default.
• W2018109748 hasAuthorship W2018109748A5025062638 @default.
• W2018109748 hasAuthorship W2018109748A5047338113 @default.
• W2018109748 hasAuthorship W2018109748A5069987608 @default.
• W2018109748 hasAuthorship W2018109748A5079143963 @default.
• W2018109748 hasAuthorship W2018109748A5086188593 @default.
• W2018109748 hasAuthorship W2018109748A5090085904 @default.
• W2018109748 hasConcept C121608353 @default.
• W2018109748 hasConcept C126322002 @default.
• W2018109748 hasConcept C142724271 @default.
• W2018109748 hasConcept C1491633281 @default.
• W2018109748 hasConcept C199835354 @default.
• W2018109748 hasConcept C204232928 @default.
• W2018109748 hasConcept C2775894508 @default.
• W2018109748 hasConcept C2777562237 @default.
• W2018109748 hasConcept C2778677798 @default.
• W2018109748 hasConcept C2779422922 @default.
• W2018109748 hasConcept C2780342937 @default.
• W2018109748 hasConcept C2908647359 @default.
• W2018109748 hasConcept C29537977 @default.
• W2018109748 hasConcept C34688535 @default.
• W2018109748 hasConcept C4224716 @default.
• W2018109748 hasConcept C54355233 @default.
• W2018109748 hasConcept C555283112 @default.
• W2018109748 hasConcept C71924100 @default.
• W2018109748 hasConcept C86803240 @default.
• W2018109748 hasConcept C99454951 @default.
• W2018109748 hasConceptScore W2018109748C121608353 @default.
• W2018109748 hasConceptScore W2018109748C126322002 @default.
• W2018109748 hasConceptScore W2018109748C142724271 @default.
• W2018109748 hasConceptScore W2018109748C1491633281 @default.
• W2018109748 hasConceptScore W2018109748C199835354 @default.
• W2018109748 hasConceptScore W2018109748C204232928 @default.
• W2018109748 hasConceptScore W2018109748C2775894508 @default.
• W2018109748 hasConceptScore W2018109748C2777562237 @default.
• W2018109748 hasConceptScore W2018109748C2778677798 @default.
• W2018109748 hasConceptScore W2018109748C2779422922 @default.
• W2018109748 hasConceptScore W2018109748C2780342937 @default.
• W2018109748 hasConceptScore W2018109748C2908647359 @default.
• W2018109748 hasConceptScore W2018109748C29537977 @default.
• W2018109748 hasConceptScore W2018109748C34688535 @default.
• W2018109748 hasConceptScore W2018109748C4224716 @default.
• W2018109748 hasConceptScore W2018109748C54355233 @default.
• W2018109748 hasConceptScore W2018109748C555283112 @default.
• W2018109748 hasConceptScore W2018109748C71924100 @default.
• W2018109748 hasConceptScore W2018109748C86803240 @default.
• W2018109748 hasConceptScore W2018109748C99454951 @default.
• W2018109748 hasIssue "4" @default.
• W2018109748 hasLocation W20181097481 @default.
• W2018109748 hasLocation W20181097482 @default.
• W2018109748 hasOpenAccess W2018109748 @default.
• W2018109748 hasPrimaryLocation W20181097481 @default.
• W2018109748 hasRelatedWork W2018109748 @default.
• W2018109748 hasRelatedWork W2027234544 @default.
• W2018109748 hasRelatedWork W2055656219 @default.

• next