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- W2018118901 abstract "Carnitine status in humans is reported to vary according to body composition, gender, and diet. Plasma carnitine concentration positively correlates with the dietary intake of carnitine. The content of carnitine in foodstuff is based on old and inadequate methodology. Nevertheless, dietary carnitine is important. The molecular biology of the enzymes of carnitine biosynthesis has recently been accomplished. Carnitine biosynthesis requires pathways in different tissues and is an efficient system. Overall biosynthesis is determined by the availability of trimethyllysine from tissue proteins. Carnitine deficiency resulting from a defect in biosynthesis has yet to be reported. The role of carnitine in long-chain fatty acid oxidation is well defined. Recent evidence supports a role for the voltage-dependent anion channel in the transport of acyl-CoAs through the mitochondrial outer membrane. The mitochondrial outer membrane carnitine palmitoyltransferase-I in liver can be phosphorylated and when phosphorylated the sensitivity to malonyl-CoA is greatly decreased. This may explain the change in sensitivity of liver carnitine palmitoyltransferase-I observed during fasting and diabetes. Recently reported data clarify the role of carnitine and the carnitine transport system in the interplay between peroxisomes and mitochondrial fatty acid oxidation. Lastly, the buffering of the acyl-CoA/CoA coupled by carnitine reflects intracellular metabolism. This mass action effect underlies the use of carnitine as a therapeutic agent. In summary, these new observations help to further our understanding of the molecular aspects of carnitine in medicine." @default.
- W2018118901 created "2016-06-24" @default.
- W2018118901 creator A5025700740 @default.
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- W2018118901 date "2004-12-01" @default.
- W2018118901 modified "2023-10-15" @default.
- W2018118901 title "Carnitine: a nutritional, biosynthetic, and functional perspective" @default.
- W2018118901 cites W1277551767 @default.
- W2018118901 cites W1488687890 @default.
- W2018118901 cites W1495212988 @default.
- W2018118901 cites W149806117 @default.
- W2018118901 cites W155501327 @default.
- W2018118901 cites W1594898501 @default.
- W2018118901 cites W1595092951 @default.
- W2018118901 cites W1598629558 @default.
- W2018118901 cites W1749735570 @default.
- W2018118901 cites W176808905 @default.
- W2018118901 cites W1775915449 @default.
- W2018118901 cites W1858562613 @default.
- W2018118901 cites W1890236003 @default.
- W2018118901 cites W1904563748 @default.
- W2018118901 cites W1942547537 @default.
- W2018118901 cites W1963817811 @default.
- W2018118901 cites W1966264563 @default.
- W2018118901 cites W1966831974 @default.
- W2018118901 cites W1970223493 @default.
- W2018118901 cites W1971333394 @default.
- W2018118901 cites W1973003527 @default.
- W2018118901 cites W1973181474 @default.
- W2018118901 cites W1976568495 @default.
- W2018118901 cites W1982991739 @default.
- W2018118901 cites W1988632024 @default.
- W2018118901 cites W1988767514 @default.
- W2018118901 cites W1989341494 @default.
- W2018118901 cites W1990133115 @default.
- W2018118901 cites W1990731992 @default.
- W2018118901 cites W1991074212 @default.
- W2018118901 cites W1991173567 @default.
- W2018118901 cites W1991487031 @default.
- W2018118901 cites W1993104242 @default.
- W2018118901 cites W1995669260 @default.
- W2018118901 cites W1996780193 @default.
- W2018118901 cites W2001205503 @default.
- W2018118901 cites W2006024908 @default.
- W2018118901 cites W2007486805 @default.
- W2018118901 cites W2007814471 @default.
- W2018118901 cites W2010589613 @default.
- W2018118901 cites W2010976466 @default.
- W2018118901 cites W2015832516 @default.
- W2018118901 cites W2025057200 @default.
- W2018118901 cites W2028774478 @default.
- W2018118901 cites W2029143189 @default.
- W2018118901 cites W2029286121 @default.
- W2018118901 cites W2029970717 @default.
- W2018118901 cites W2031824341 @default.
- W2018118901 cites W2031846075 @default.
- W2018118901 cites W2033674260 @default.
- W2018118901 cites W2035614447 @default.
- W2018118901 cites W2041395926 @default.
- W2018118901 cites W2050724479 @default.
- W2018118901 cites W2051542544 @default.
- W2018118901 cites W2057816478 @default.
- W2018118901 cites W2060065383 @default.
- W2018118901 cites W2060822564 @default.
- W2018118901 cites W2060833674 @default.
- W2018118901 cites W2062412316 @default.
- W2018118901 cites W2063977510 @default.
- W2018118901 cites W2067449320 @default.
- W2018118901 cites W2070226181 @default.
- W2018118901 cites W207208947 @default.
- W2018118901 cites W2075900968 @default.
- W2018118901 cites W207816677 @default.
- W2018118901 cites W2084194858 @default.
- W2018118901 cites W2091598724 @default.
- W2018118901 cites W2099566887 @default.
- W2018118901 cites W2102083512 @default.
- W2018118901 cites W2113570049 @default.
- W2018118901 cites W2113622084 @default.
- W2018118901 cites W2114853986 @default.
- W2018118901 cites W2115941718 @default.
- W2018118901 cites W2119546730 @default.
- W2018118901 cites W2119675339 @default.
- W2018118901 cites W2124397810 @default.
- W2018118901 cites W2130735275 @default.
- W2018118901 cites W2134032476 @default.
- W2018118901 cites W2161310946 @default.
- W2018118901 cites W2170085053 @default.
- W2018118901 cites W2181491234 @default.
- W2018118901 cites W2187762085 @default.
- W2018118901 cites W2225082774 @default.
- W2018118901 cites W2234558981 @default.
- W2018118901 cites W2263566899 @default.
- W2018118901 cites W2276784994 @default.
- W2018118901 cites W2300372829 @default.
- W2018118901 cites W2339865089 @default.
- W2018118901 cites W2413612966 @default.
- W2018118901 cites W25773167 @default.