FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018124553> ?p ?o ?g. }

• W2018124553 endingPage "1037" @default.
• W2018124553 startingPage "1030" @default.
• W2018124553 abstract "Focal adhesion kinase (FAK), a non-receptor protein kinase, is known to be a phosphatidyl inositol 3-kinase (PI3K) pathway activator and thus widely implicated in regulation of cell survival and cancer. In recent years FAK has also been strongly implicated as a crucial regulator of insulin resistance in peripheral tissues like skeletal muscle and liver, where decrease in its expression/activity has been shown to lead to insulin resistance. However, in the present study we report an altogether different role of FAK in regulation of insulin/PI3K signaling in neurons, the post-mitotic cells. An aberrant increase in FAK tyrosine phosphorylation was observed in insulin resistant Neuro-2a (N2A) cells. Downregulation of FAK expression utilizing RNAi mediated gene silencing in insulin resistant N2A cells completely ameliorated the impaired insulin/PI3K signaling and glucose uptake. FAK silencing in primary cortical neurons also showed marked enhancement in glucose uptake. The results thus suggest that in neurons FAK acts as a negative regulator of insulin/PI3K signaling. Interestingly, the available literature also demonstrates cell-type specific functions of FAK in neurons. FAK that is well known for its cell survival effects has been shown to be involved in neurodegeneration. Along with these previous reports, present findings highlight a novel and critical role of FAK in neurons. Moreover, as this implicates differential regulation of insulin/PI3K pathway by FAK in peripheral tissues and neuronal cells, it strongly suggests precaution while considering FAK modulators as possible therapeutics." @default.
• W2018124553 created "2016-06-24" @default.
• W2018124553 creator A5006629075 @default.
• W2018124553 creator A5058405202 @default.
• W2018124553 creator A5091490229 @default.
• W2018124553 date "2012-06-01" @default.
• W2018124553 modified "2023-09-26" @default.
• W2018124553 title "Focal adhesion kinase negatively regulates neuronal insulin resistance" @default.
• W2018124553 cites W1525249836 @default.
• W2018124553 cites W1528865376 @default.
• W2018124553 cites W1532590486 @default.
• W2018124553 cites W1543788907 @default.
• W2018124553 cites W1554056120 @default.
• W2018124553 cites W1562586507 @default.
• W2018124553 cites W1841303832 @default.
• W2018124553 cites W1847398151 @default.
• W2018124553 cites W1974195264 @default.
• W2018124553 cites W1991140296 @default.
• W2018124553 cites W1995788052 @default.
• W2018124553 cites W1998819602 @default.
• W2018124553 cites W2000351678 @default.
• W2018124553 cites W2001587874 @default.
• W2018124553 cites W2001599368 @default.
• W2018124553 cites W2011430246 @default.
• W2018124553 cites W2025787878 @default.
• W2018124553 cites W2033676859 @default.
• W2018124553 cites W2035825704 @default.
• W2018124553 cites W2047131896 @default.
• W2018124553 cites W2054543840 @default.
• W2018124553 cites W2060057909 @default.
• W2018124553 cites W2063014525 @default.
• W2018124553 cites W2063014852 @default.
• W2018124553 cites W2073967350 @default.
• W2018124553 cites W2074031136 @default.
• W2018124553 cites W2074161856 @default.
• W2018124553 cites W2076649773 @default.
• W2018124553 cites W2077033935 @default.
• W2018124553 cites W2078726855 @default.
• W2018124553 cites W2094875935 @default.
• W2018124553 cites W2114027579 @default.
• W2018124553 cites W2117142298 @default.
• W2018124553 cites W2124757700 @default.
• W2018124553 cites W2124956707 @default.
• W2018124553 cites W2135148756 @default.
• W2018124553 cites W2136051455 @default.
• W2018124553 cites W2140635558 @default.
• W2018124553 cites W2148560401 @default.
• W2018124553 cites W2151465836 @default.
• W2018124553 doi "https://doi.org/10.1016/j.bbadis.2012.02.011" @default.
• W2018124553 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22366060" @default.
• W2018124553 hasPublicationYear "2012" @default.
• W2018124553 type Work @default.
• W2018124553 sameAs 2018124553 @default.
• W2018124553 citedByCount "23" @default.
• W2018124553 countsByYear W20181245532012 @default.
• W2018124553 countsByYear W20181245532013 @default.
• W2018124553 countsByYear W20181245532014 @default.
• W2018124553 countsByYear W20181245532015 @default.
• W2018124553 countsByYear W20181245532016 @default.
• W2018124553 countsByYear W20181245532017 @default.
• W2018124553 countsByYear W20181245532018 @default.
• W2018124553 countsByYear W20181245532019 @default.
• W2018124553 countsByYear W20181245532020 @default.
• W2018124553 countsByYear W20181245532021 @default.
• W2018124553 countsByYear W20181245532022 @default.
• W2018124553 countsByYear W20181245532023 @default.
• W2018124553 crossrefType "journal-article" @default.
• W2018124553 hasAuthorship W2018124553A5006629075 @default.
• W2018124553 hasAuthorship W2018124553A5058405202 @default.
• W2018124553 hasAuthorship W2018124553A5091490229 @default.
• W2018124553 hasBestOaLocation W20181245531 @default.
• W2018124553 hasConcept C104317684 @default.
• W2018124553 hasConcept C112446052 @default.
• W2018124553 hasConcept C119056186 @default.
• W2018124553 hasConcept C127561419 @default.
• W2018124553 hasConcept C134018914 @default.
• W2018124553 hasConcept C151166631 @default.
• W2018124553 hasConcept C2777391703 @default.
• W2018124553 hasConcept C2779306644 @default.
• W2018124553 hasConcept C55493867 @default.
• W2018124553 hasConcept C62478195 @default.
• W2018124553 hasConcept C6929976 @default.
• W2018124553 hasConcept C75217442 @default.
• W2018124553 hasConcept C86554907 @default.
• W2018124553 hasConcept C86803240 @default.
• W2018124553 hasConcept C95444343 @default.
• W2018124553 hasConceptScore W2018124553C104317684 @default.
• W2018124553 hasConceptScore W2018124553C112446052 @default.
• W2018124553 hasConceptScore W2018124553C119056186 @default.
• W2018124553 hasConceptScore W2018124553C127561419 @default.
• W2018124553 hasConceptScore W2018124553C134018914 @default.
• W2018124553 hasConceptScore W2018124553C151166631 @default.
• W2018124553 hasConceptScore W2018124553C2777391703 @default.
• W2018124553 hasConceptScore W2018124553C2779306644 @default.
• W2018124553 hasConceptScore W2018124553C55493867 @default.
• W2018124553 hasConceptScore W2018124553C62478195 @default.
• W2018124553 hasConceptScore W2018124553C6929976 @default.
• W2018124553 hasConceptScore W2018124553C75217442 @default.

• next