FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018127394> ?p ?o ?g. }

• W2018127394 endingPage "1672" @default.
• W2018127394 startingPage "1668" @default.
• W2018127394 abstract "The hammerhead RNA self-cleaving domain can be assembled from two RNA molecules: a large (approximately 34 nucleotide) ribozyme RNA containing most of the catalytically essential nucleotides and a small (approximately 13 nucleotide) substrate RNA containing the cleavage site. Four such hammerheads that contained identical catalytic core sequences but differed in the base composition of the helices that are involved in substrate binding had been reported to vary in cleavage rates by more than 70-fold under similar reaction conditions. Steady-state kinetic analyses reveal that kcat values are nearly the same for these hammerheads but Km values vary nearly 60-fold. The substrates for reactions having high Km values form aggregates that are virtually nonreactive. These observations demonstrate that the secondary structure of substrate RNA can be a major determinant of hammerhead catalytic efficiency." @default.
• W2018127394 created "2016-06-24" @default.
• W2018127394 creator A5014521534 @default.
• W2018127394 creator A5043444150 @default.
• W2018127394 date "1990-03-01" @default.
• W2018127394 modified "2023-09-25" @default.
• W2018127394 title "Substrate sequence effects on hammerhead RNA catalytic efficiency." @default.
• W2018127394 cites W108515849 @default.
• W2018127394 cites W1964847149 @default.
• W2018127394 cites W1965464174 @default.
• W2018127394 cites W1971730047 @default.
• W2018127394 cites W1972928631 @default.
• W2018127394 cites W1977335029 @default.
• W2018127394 cites W1978297087 @default.
• W2018127394 cites W1986232581 @default.
• W2018127394 cites W1988628345 @default.
• W2018127394 cites W1991524704 @default.
• W2018127394 cites W1992302499 @default.
• W2018127394 cites W2014508207 @default.
• W2018127394 cites W2016329954 @default.
• W2018127394 cites W2019855583 @default.
• W2018127394 cites W2021333801 @default.
• W2018127394 cites W2038251099 @default.
• W2018127394 cites W2060510537 @default.
• W2018127394 cites W2062911181 @default.
• W2018127394 cites W2073263035 @default.
• W2018127394 cites W2078023996 @default.
• W2018127394 cites W2085272777 @default.
• W2018127394 cites W2140688225 @default.
• W2018127394 doi "https://doi.org/10.1073/pnas.87.5.1668" @default.
• W2018127394 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/53543" @default.
• W2018127394 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1689847" @default.
• W2018127394 hasPublicationYear "1990" @default.
• W2018127394 type Work @default.
• W2018127394 sameAs 2018127394 @default.
• W2018127394 citedByCount "221" @default.
• W2018127394 countsByYear W20181273942012 @default.
• W2018127394 countsByYear W20181273942013 @default.
• W2018127394 countsByYear W20181273942014 @default.
• W2018127394 countsByYear W20181273942015 @default.
• W2018127394 countsByYear W20181273942016 @default.
• W2018127394 countsByYear W20181273942019 @default.
• W2018127394 countsByYear W20181273942021 @default.
• W2018127394 crossrefType "journal-article" @default.
• W2018127394 hasAuthorship W2018127394A5014521534 @default.
• W2018127394 hasAuthorship W2018127394A5043444150 @default.
• W2018127394 hasBestOaLocation W20181273942 @default.
• W2018127394 hasConcept C104317684 @default.
• W2018127394 hasConcept C107745601 @default.
• W2018127394 hasConcept C1342335 @default.
• W2018127394 hasConcept C151730666 @default.
• W2018127394 hasConcept C161790260 @default.
• W2018127394 hasConcept C175156509 @default.
• W2018127394 hasConcept C185581394 @default.
• W2018127394 hasConcept C185592680 @default.
• W2018127394 hasConcept C18903297 @default.
• W2018127394 hasConcept C2777289219 @default.
• W2018127394 hasConcept C2779792011 @default.
• W2018127394 hasConcept C41183919 @default.
• W2018127394 hasConcept C43369102 @default.
• W2018127394 hasConcept C512185932 @default.
• W2018127394 hasConcept C552990157 @default.
• W2018127394 hasConcept C55493867 @default.
• W2018127394 hasConcept C56856141 @default.
• W2018127394 hasConcept C66144319 @default.
• W2018127394 hasConcept C67705224 @default.
• W2018127394 hasConcept C71240020 @default.
• W2018127394 hasConcept C76346623 @default.
• W2018127394 hasConcept C86803240 @default.
• W2018127394 hasConceptScore W2018127394C104317684 @default.
• W2018127394 hasConceptScore W2018127394C107745601 @default.
• W2018127394 hasConceptScore W2018127394C1342335 @default.
• W2018127394 hasConceptScore W2018127394C151730666 @default.
• W2018127394 hasConceptScore W2018127394C161790260 @default.
• W2018127394 hasConceptScore W2018127394C175156509 @default.
• W2018127394 hasConceptScore W2018127394C185581394 @default.
• W2018127394 hasConceptScore W2018127394C185592680 @default.
• W2018127394 hasConceptScore W2018127394C18903297 @default.
• W2018127394 hasConceptScore W2018127394C2777289219 @default.
• W2018127394 hasConceptScore W2018127394C2779792011 @default.
• W2018127394 hasConceptScore W2018127394C41183919 @default.
• W2018127394 hasConceptScore W2018127394C43369102 @default.
• W2018127394 hasConceptScore W2018127394C512185932 @default.
• W2018127394 hasConceptScore W2018127394C552990157 @default.
• W2018127394 hasConceptScore W2018127394C55493867 @default.
• W2018127394 hasConceptScore W2018127394C56856141 @default.
• W2018127394 hasConceptScore W2018127394C66144319 @default.
• W2018127394 hasConceptScore W2018127394C67705224 @default.
• W2018127394 hasConceptScore W2018127394C71240020 @default.
• W2018127394 hasConceptScore W2018127394C76346623 @default.
• W2018127394 hasConceptScore W2018127394C86803240 @default.
• W2018127394 hasIssue "5" @default.
• W2018127394 hasLocation W20181273941 @default.
• W2018127394 hasLocation W20181273942 @default.
• W2018127394 hasLocation W20181273943 @default.
• W2018127394 hasLocation W20181273944 @default.
• W2018127394 hasOpenAccess W2018127394 @default.
• W2018127394 hasPrimaryLocation W20181273941 @default.

• next