FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018127407> ?p ?o ?g. }

• W2018127407 endingPage "2114" @default.
• W2018127407 startingPage "2103" @default.
• W2018127407 abstract "The results of animal research suggest that the use of partial agonists at dopamine (DA) D2 receptors may be an effective strategy for the treatment of stimulant dependence. Aripiprazole is an atypical antipsychotic that has partial agonist activity at D2 receptors. In this experiment, seven human participants with a history of nontherapeutic stimulant use learned to discriminate 15 mg oral D-amphetamine. After acquiring the discrimination (ie > or =80% correct responding on four consecutive sessions), the effects of a range of doses of D-amphetamine (0, 2.5, 5, 10, and 15 mg), alone and in combination with aripiprazole (0 and 20 mg), were assessed. D-Amphetamine alone functioned as a discriminative stimulus, produced prototypical subject-rated drug effects (eg increased ratings of Active, Alert, Energetic) and elevated cardiovascular indices. These effects were generally a function of dose. Aripiprazole alone did not occasion D-amphetamine-appropriate responding or produce subject-rated effects, but modestly impaired performance. Administration of aripiprazole significantly attenuated the discriminative-stimulus and cardiovascular effects of D-amphetamine, as well as some of the subject-rated drug effects. These data are consistent with previous preclinical findings and suggest that DA partial agonists deserve further evaluation as potential pharmacotherapies in the management of stimulant dependence. Future studies should investigate the ability of aripiprazole or related compounds to attenuate the behavioral effects of stimulants associated with a greater degree of dependence, such as methamphetamine or cocaine, in dependent individuals." @default.
• W2018127407 created "2016-06-24" @default.
• W2018127407 creator A5003807463 @default.
• W2018127407 creator A5005871820 @default.
• W2018127407 creator A5035344925 @default.
• W2018127407 creator A5036283865 @default.
• W2018127407 creator A5071583939 @default.
• W2018127407 creator A5074561564 @default.
• W2018127407 date "2005-06-29" @default.
• W2018127407 modified "2023-10-17" @default.
• W2018127407 title "Aripiprazole Attenuates the Discriminative-Stimulus and Subject-Rated Effects of D-Amphetamine in Humans" @default.
• W2018127407 cites W1965182972 @default.
• W2018127407 cites W1966699659 @default.
• W2018127407 cites W1971179661 @default.
• W2018127407 cites W1991666427 @default.
• W2018127407 cites W1994504165 @default.
• W2018127407 cites W1998959237 @default.
• W2018127407 cites W2001047889 @default.
• W2018127407 cites W2001321361 @default.
• W2018127407 cites W2004085525 @default.
• W2018127407 cites W2005947884 @default.
• W2018127407 cites W2008032124 @default.
• W2018127407 cites W2025339047 @default.
• W2018127407 cites W2029589254 @default.
• W2018127407 cites W2033705393 @default.
• W2018127407 cites W2034719708 @default.
• W2018127407 cites W2047147502 @default.
• W2018127407 cites W2047423810 @default.
• W2018127407 cites W2049743610 @default.
• W2018127407 cites W2050016013 @default.
• W2018127407 cites W2050019172 @default.
• W2018127407 cites W2061458284 @default.
• W2018127407 cites W2061837419 @default.
• W2018127407 cites W2068890509 @default.
• W2018127407 cites W2070357412 @default.
• W2018127407 cites W2071828273 @default.
• W2018127407 cites W2071905237 @default.
• W2018127407 cites W2078106738 @default.
• W2018127407 cites W2079257107 @default.
• W2018127407 cites W2093757762 @default.
• W2018127407 cites W2120219218 @default.
• W2018127407 cites W2242713226 @default.
• W2018127407 cites W2322549652 @default.
• W2018127407 cites W3191110341 @default.
• W2018127407 cites W4323237072 @default.
• W2018127407 cites W47927121 @default.
• W2018127407 cites W54728729 @default.
• W2018127407 doi "https://doi.org/10.1038/sj.npp.1300803" @default.
• W2018127407 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15988473" @default.
• W2018127407 hasPublicationYear "2005" @default.
• W2018127407 type Work @default.
• W2018127407 sameAs 2018127407 @default.
• W2018127407 citedByCount "70" @default.
• W2018127407 countsByYear W20181274072012 @default.
• W2018127407 countsByYear W20181274072013 @default.
• W2018127407 countsByYear W20181274072014 @default.
• W2018127407 countsByYear W20181274072016 @default.
• W2018127407 countsByYear W20181274072017 @default.
• W2018127407 countsByYear W20181274072020 @default.
• W2018127407 countsByYear W20181274072022 @default.
• W2018127407 crossrefType "journal-article" @default.
• W2018127407 hasAuthorship W2018127407A5003807463 @default.
• W2018127407 hasAuthorship W2018127407A5005871820 @default.
• W2018127407 hasAuthorship W2018127407A5035344925 @default.
• W2018127407 hasAuthorship W2018127407A5036283865 @default.
• W2018127407 hasAuthorship W2018127407A5071583939 @default.
• W2018127407 hasAuthorship W2018127407A5074561564 @default.
• W2018127407 hasBestOaLocation W20181274071 @default.
• W2018127407 hasConcept C118552586 @default.
• W2018127407 hasConcept C126322002 @default.
• W2018127407 hasConcept C15744967 @default.
• W2018127407 hasConcept C169760540 @default.
• W2018127407 hasConcept C170493617 @default.
• W2018127407 hasConcept C2776412080 @default.
• W2018127407 hasConcept C2777193897 @default.
• W2018127407 hasConcept C2778938600 @default.
• W2018127407 hasConcept C2779547902 @default.
• W2018127407 hasConcept C2780211496 @default.
• W2018127407 hasConcept C2780376393 @default.
• W2018127407 hasConcept C2780494398 @default.
• W2018127407 hasConcept C2780557958 @default.
• W2018127407 hasConcept C513476851 @default.
• W2018127407 hasConcept C57022672 @default.
• W2018127407 hasConcept C58732023 @default.
• W2018127407 hasConcept C71924100 @default.
• W2018127407 hasConcept C98274493 @default.
• W2018127407 hasConceptScore W2018127407C118552586 @default.
• W2018127407 hasConceptScore W2018127407C126322002 @default.
• W2018127407 hasConceptScore W2018127407C15744967 @default.
• W2018127407 hasConceptScore W2018127407C169760540 @default.
• W2018127407 hasConceptScore W2018127407C170493617 @default.
• W2018127407 hasConceptScore W2018127407C2776412080 @default.
• W2018127407 hasConceptScore W2018127407C2777193897 @default.
• W2018127407 hasConceptScore W2018127407C2778938600 @default.
• W2018127407 hasConceptScore W2018127407C2779547902 @default.
• W2018127407 hasConceptScore W2018127407C2780211496 @default.
• W2018127407 hasConceptScore W2018127407C2780376393 @default.
• W2018127407 hasConceptScore W2018127407C2780494398 @default.

• next