FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018128419> ?p ?o ?g. }

• W2018128419 endingPage "127" @default.
• W2018128419 startingPage "121" @default.
• W2018128419 abstract "The urea cycle and nitric oxide cycle play significant roles in complex biochemical and physiologic reactions. These cycles have distinct biochemical goals including the clearance of waste nitrogen; the production of the intermediates ornithine, citrulline, and arginine for the urea cycle; and the production of nitric oxide for the nitric oxide pathway. Despite their disparate functions, the two pathways share two enzymes, argininosuccinic acid synthase and argininosuccinic acid lyase, and a transporter, citrin. Studying the gene expression of these enzymes is paramount in understanding these complex biochemical pathways. Here, we examine the expression of genes involved in the urea cycle and the nitric oxide cycle in a panel of eleven different tissue samples obtained from individual adults without known inborn errors of metabolism. In this study, the pattern of co-expressed enzymes provides a global view of the metabolic activity of the urea and nitric oxide cycles in human tissues. Our results show that these transcripts are differentially expressed in different tissues. Using the co-expression profiles, we discovered that the combination of expression of enzyme transcripts as detected in our study, might serve to fulfill specific physiologic function(s) including urea production/nitrogen removal, arginine/citrulline production, nitric oxide production, and ornithine production. Our study reveals the importance of studying not only the expression profile of an enzyme of interest, but also studying the expression profiles of the other enzymes involved in a particular pathway so as to better understand the context of expression. The tissue patterns we observed highlight the variety of important functions of these enzymes and provides insight into the many clinical observations that result from their disruption. These results have implications for the management of urea cycle patients and raise considerations for the care of those patients receiving liver transplants. Finally, this work reaffirms the concept that the co-expression of a few genes can significantly impact complex biochemical and physiologic processes." @default.
• W2018128419 created "2016-06-24" @default.
• W2018128419 creator A5010229551 @default.
• W2018128419 creator A5014914092 @default.
• W2018128419 creator A5035157661 @default.
• W2018128419 creator A5045924800 @default.
• W2018128419 date "2009-06-01" @default.
• W2018128419 modified "2023-09-26" @default.
• W2018128419 title "Quantitative RT-PCR comparison of the urea and nitric oxide cycle gene transcripts in adult human tissues" @default.
• W2018128419 cites W1599462883 @default.
• W2018128419 cites W1969610841 @default.
• W2018128419 cites W1988338837 @default.
• W2018128419 cites W1991074341 @default.
• W2018128419 cites W1995985646 @default.
• W2018128419 cites W1998279940 @default.
• W2018128419 cites W2001819473 @default.
• W2018128419 cites W2004194863 @default.
• W2018128419 cites W2012026140 @default.
• W2018128419 cites W2015583679 @default.
• W2018128419 cites W2025071203 @default.
• W2018128419 cites W2042099599 @default.
• W2018128419 cites W2056321541 @default.
• W2018128419 cites W2058403295 @default.
• W2018128419 cites W2061423530 @default.
• W2018128419 cites W2070197555 @default.
• W2018128419 cites W2071808643 @default.
• W2018128419 cites W2079276179 @default.
• W2018128419 cites W2081143980 @default.
• W2018128419 cites W2084620241 @default.
• W2018128419 cites W2086382188 @default.
• W2018128419 cites W2098366405 @default.
• W2018128419 cites W2101982383 @default.
• W2018128419 cites W2110845969 @default.
• W2018128419 cites W2134102477 @default.
• W2018128419 cites W2137185879 @default.
• W2018128419 cites W2175413019 @default.
• W2018128419 cites W2178289462 @default.
• W2018128419 cites W2319036533 @default.
• W2018128419 cites W2415125453 @default.
• W2018128419 cites W2432195370 @default.
• W2018128419 cites W2460419807 @default.
• W2018128419 cites W2461033074 @default.
• W2018128419 cites W9195784 @default.
• W2018128419 doi "https://doi.org/10.1016/j.ymgme.2009.02.009" @default.
• W2018128419 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2680466" @default.
• W2018128419 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19345634" @default.
• W2018128419 hasPublicationYear "2009" @default.
• W2018128419 type Work @default.
• W2018128419 sameAs 2018128419 @default.
• W2018128419 citedByCount "31" @default.
• W2018128419 countsByYear W20181284192012 @default.
• W2018128419 countsByYear W20181284192013 @default.
• W2018128419 countsByYear W20181284192014 @default.
• W2018128419 countsByYear W20181284192015 @default.
• W2018128419 countsByYear W20181284192016 @default.
• W2018128419 countsByYear W20181284192017 @default.
• W2018128419 countsByYear W20181284192019 @default.
• W2018128419 countsByYear W20181284192020 @default.
• W2018128419 countsByYear W20181284192021 @default.
• W2018128419 countsByYear W20181284192022 @default.
• W2018128419 crossrefType "journal-article" @default.
• W2018128419 hasAuthorship W2018128419A5010229551 @default.
• W2018128419 hasAuthorship W2018128419A5014914092 @default.
• W2018128419 hasAuthorship W2018128419A5035157661 @default.
• W2018128419 hasAuthorship W2018128419A5045924800 @default.
• W2018128419 hasBestOaLocation W20181284192 @default.
• W2018128419 hasConcept C104317684 @default.
• W2018128419 hasConcept C134018914 @default.
• W2018128419 hasConcept C150194340 @default.
• W2018128419 hasConcept C151730666 @default.
• W2018128419 hasConcept C164007495 @default.
• W2018128419 hasConcept C181199279 @default.
• W2018128419 hasConcept C185592680 @default.
• W2018128419 hasConcept C192989942 @default.
• W2018128419 hasConcept C2776796294 @default.
• W2018128419 hasConcept C2777468819 @default.
• W2018128419 hasConcept C2777622882 @default.
• W2018128419 hasConcept C2779129087 @default.
• W2018128419 hasConcept C2779343474 @default.
• W2018128419 hasConcept C515207424 @default.
• W2018128419 hasConcept C519581460 @default.
• W2018128419 hasConcept C55493867 @default.
• W2018128419 hasConcept C77061444 @default.
• W2018128419 hasConcept C86803240 @default.
• W2018128419 hasConcept C95444343 @default.
• W2018128419 hasConceptScore W2018128419C104317684 @default.
• W2018128419 hasConceptScore W2018128419C134018914 @default.
• W2018128419 hasConceptScore W2018128419C150194340 @default.
• W2018128419 hasConceptScore W2018128419C151730666 @default.
• W2018128419 hasConceptScore W2018128419C164007495 @default.
• W2018128419 hasConceptScore W2018128419C181199279 @default.
• W2018128419 hasConceptScore W2018128419C185592680 @default.
• W2018128419 hasConceptScore W2018128419C192989942 @default.
• W2018128419 hasConceptScore W2018128419C2776796294 @default.
• W2018128419 hasConceptScore W2018128419C2777468819 @default.
• W2018128419 hasConceptScore W2018128419C2777622882 @default.
• W2018128419 hasConceptScore W2018128419C2779129087 @default.
• W2018128419 hasConceptScore W2018128419C2779343474 @default.

• next