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- W2018130291 endingPage "380" @default.
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- W2018130291 abstract "Novel biodegradable poly(carbonate ester)s with photolabile protecting groups were synthesized by ring-opening copolymerization of L-lactide (LA) with 5-methyl-5-(2-nitro-benzoxycarbonyl)-1,3-dioxan-2-one (MNC) with diethyl zinc (Et2Zn) as catalyst. The poly(L-lactide-co-5-methyl-5-carboxyl-1,3-dioxan-2-one) (P(LA-co-MCC)) was obtained by UV irradiation of poly(L-lactide acid-co-5-methyl-5-(2-nitro-benzoxycarbonyl)-1,3-dioxan-2-one) (P(LA-co-MNC)) to remove the protective 2-nitrobenzyl group. The free carboxyl groups on the copolymers P(LA-co-MCC) were reacted with paclitaxel, a common antitumor drug. Gel permeation chromatography and NMR studies confirmed the copolymer structures and successful attachment of paclitaxel to the copolymer." @default.
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- W2018130291 date "2007-12-08" @default.
- W2018130291 modified "2023-10-13" @default.
- W2018130291 title "Synthesis and Characterization of Novel Biodegradable Poly(carbonate ester)s with Photolabile Protecting Groups" @default.
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- W2018130291 doi "https://doi.org/10.1021/bm700906k" @default.
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