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- W2018138768 abstract "The syntheses of arene-fused prostacyclin analogs 2 and 3 are described. Rapid assembly of the tricyclic skeleton is achieved in a triply-convergent manner from oxazoline-bearing homocuprate 6b, homochiral ammonium salt 7 and homochiral propargyl acetylide 12. Compound 2 was a potent inhibitor of collagen-induced platelet aggregation having an IC50 = 2.9nM; while 3 exhibited an IC50 = 52nM." @default.
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- W2018138768 date "1991-01-01" @default.
- W2018138768 modified "2023-09-24" @default.
- W2018138768 title "Triply-convergent syntheses of two homochiral arene-fused prostacyclin analogs related to U68,215" @default.
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- W2018138768 doi "https://doi.org/10.1016/s0960-894x(01)81097-0" @default.
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