Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018140880> ?p ?o ?g. }
- W2018140880 endingPage "4398" @default.
- W2018140880 startingPage "4386" @default.
- W2018140880 abstract "Efficient Pd(0)-catalysed synthesis of 5-alkynyl-1-β-d-ribofuranosyl-1H-[1,2,3]triazole-4-carboxylic acid amide depends on the presence of different protecting groups of the ribose moiety. Peracetylated 5-iodo substrate (15) couples with terminal alkynes or trimethyl-[(tributylstannyl)ethynyl]silane in 50–71% and 72% yield (ETCAR), respectively, although its hydrodehalogenation to 19 is noticeable. On the other hand, hydrodehalogenation of acetonide (16) predominates over coupling with terminal alkyne and slightly decreases a yield of cross-coupling reaction with trimethyl[(tributylstannyl)ethynyl]silane. Alternative conditions of reaction with terminal alkynes, to exclude so far identified hydride sources to produce hydridopalladium species, have been established for acetonide 16 and allowed to achieve 72% of coupling. Fluoromethyl derivative (42) was prepared from its 5-hydroxymethyl precursor by fluorination with DAST. Additionally, X-ray structural analysis of 42 was performed. All 1,2,3-triazolonucleosides and two synthesized cycloSal-pronucleotides were evaluated for cytotoxic activity against K562, HeLa and HUVEC cells." @default.
- W2018140880 created "2016-06-24" @default.
- W2018140880 creator A5008459525 @default.
- W2018140880 creator A5009540416 @default.
- W2018140880 creator A5048398642 @default.
- W2018140880 creator A5059015364 @default.
- W2018140880 creator A5063389250 @default.
- W2018140880 creator A5065679567 @default.
- W2018140880 creator A5086438008 @default.
- W2018140880 date "2011-07-01" @default.
- W2018140880 modified "2023-10-18" @default.
- W2018140880 title "5-Ethynyl-1-β-d-ribofuranosyl-1H-[1,2,3]triazole-4-carboxylic acid amide (ETCAR) and its analogues: Synthesis and cytotoxic properties" @default.
- W2018140880 cites W1967729000 @default.
- W2018140880 cites W1970557678 @default.
- W2018140880 cites W1972835119 @default.
- W2018140880 cites W1979381093 @default.
- W2018140880 cites W1980590042 @default.
- W2018140880 cites W1981203995 @default.
- W2018140880 cites W1983892395 @default.
- W2018140880 cites W1986307323 @default.
- W2018140880 cites W1987098640 @default.
- W2018140880 cites W1988574239 @default.
- W2018140880 cites W1995679404 @default.
- W2018140880 cites W1996448661 @default.
- W2018140880 cites W2004029783 @default.
- W2018140880 cites W2004487345 @default.
- W2018140880 cites W2006369820 @default.
- W2018140880 cites W2012051375 @default.
- W2018140880 cites W2022476771 @default.
- W2018140880 cites W2027868702 @default.
- W2018140880 cites W2028515610 @default.
- W2018140880 cites W2037529225 @default.
- W2018140880 cites W2059520775 @default.
- W2018140880 cites W2063334178 @default.
- W2018140880 cites W2064721260 @default.
- W2018140880 cites W2065840168 @default.
- W2018140880 cites W2067816140 @default.
- W2018140880 cites W2085017307 @default.
- W2018140880 cites W2085639736 @default.
- W2018140880 cites W2086945873 @default.
- W2018140880 cites W2091164527 @default.
- W2018140880 cites W2098554674 @default.
- W2018140880 cites W2110870592 @default.
- W2018140880 cites W2130411043 @default.
- W2018140880 cites W2131350133 @default.
- W2018140880 cites W2140284126 @default.
- W2018140880 cites W2153918414 @default.
- W2018140880 cites W2158975656 @default.
- W2018140880 cites W2177506116 @default.
- W2018140880 cites W2949742228 @default.
- W2018140880 cites W2950880529 @default.
- W2018140880 cites W2951505772 @default.
- W2018140880 cites W2951796654 @default.
- W2018140880 cites W4295915912 @default.
- W2018140880 doi "https://doi.org/10.1016/j.bmc.2011.05.050" @default.
- W2018140880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21684167" @default.
- W2018140880 hasPublicationYear "2011" @default.
- W2018140880 type Work @default.
- W2018140880 sameAs 2018140880 @default.
- W2018140880 citedByCount "26" @default.
- W2018140880 countsByYear W20181408802013 @default.
- W2018140880 countsByYear W20181408802014 @default.
- W2018140880 countsByYear W20181408802015 @default.
- W2018140880 countsByYear W20181408802016 @default.
- W2018140880 countsByYear W20181408802017 @default.
- W2018140880 countsByYear W20181408802018 @default.
- W2018140880 countsByYear W20181408802019 @default.
- W2018140880 countsByYear W20181408802020 @default.
- W2018140880 countsByYear W20181408802021 @default.
- W2018140880 countsByYear W20181408802022 @default.
- W2018140880 crossrefType "journal-article" @default.
- W2018140880 hasAuthorship W2018140880A5008459525 @default.
- W2018140880 hasAuthorship W2018140880A5009540416 @default.
- W2018140880 hasAuthorship W2018140880A5048398642 @default.
- W2018140880 hasAuthorship W2018140880A5059015364 @default.
- W2018140880 hasAuthorship W2018140880A5063389250 @default.
- W2018140880 hasAuthorship W2018140880A5065679567 @default.
- W2018140880 hasAuthorship W2018140880A5086438008 @default.
- W2018140880 hasConcept C114373084 @default.
- W2018140880 hasConcept C134121241 @default.
- W2018140880 hasConcept C155647269 @default.
- W2018140880 hasConcept C161790260 @default.
- W2018140880 hasConcept C178790620 @default.
- W2018140880 hasConcept C185592680 @default.
- W2018140880 hasConcept C191897082 @default.
- W2018140880 hasConcept C192562407 @default.
- W2018140880 hasConcept C202751555 @default.
- W2018140880 hasConcept C2776568683 @default.
- W2018140880 hasConcept C2778439535 @default.
- W2018140880 hasConcept C2779012754 @default.
- W2018140880 hasConcept C2779074116 @default.
- W2018140880 hasConcept C2780591741 @default.
- W2018140880 hasConcept C55493867 @default.
- W2018140880 hasConcept C71240020 @default.
- W2018140880 hasConceptScore W2018140880C114373084 @default.
- W2018140880 hasConceptScore W2018140880C134121241 @default.
- W2018140880 hasConceptScore W2018140880C155647269 @default.
- W2018140880 hasConceptScore W2018140880C161790260 @default.