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- W2018141005 abstract "Under discussion are the results of experiments carried out on dogs as to the effects of circulating toxics on cardiac efficiency in septic shock. The coronary system of an isolated heart - preload and after load being constant - is perfused in an extra corporal circulatory system of a normal dog and after determination of the initial rates in that of an infected dog. Calculation of the parameters determining the cardiac output is done on-line by a digital computer. After perfusion with blood from septicaemic animals a process in two stages can be observed. The early stage - up to approximately 3 hours - is characterized by the sympathico-adrenergic response of the support dog. As soon as the masking catecholamines no longer take their effect and after failure of the adaptive mechanisms the myocardiac output will be limited. A point of no return will be reached after approximately 6 hours, being indicated by an increase in the end diastolic pressure of the left ventricle. There will be an increase in the consumption of oxygen during the early stages which correlates to the sympathico-adrenergic stimulation and to an increase in the maximum of velocity of pressure. The autoregulation being intact, the increased demand for energy is fully balanced by the coronary blood supply." @default.
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- W2018141005 date "1980-08-01" @default.
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- W2018141005 title "Untersuchungen über die Kontraktionsdynamik des Herzens im bakteriotoxischen Schock1" @default.
- W2018141005 doi "https://doi.org/10.1055/s-2008-1066375" @default.
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