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• W2018144611 abstract "To assess the role of platelets in thrombohemorrhagic complications of acute respiratory failure (ARF), we studied platelet function in 13 ARF patients admitted for intensive care, in six acutely ill intensive care patients without evidence of acute lung injury (non-ARF), and in 10 normal subjects. Platelet counts in ARF and non-ARF patients were similar to the normal range. The bleeding time of the ARF patients (8.5 ± 0.9 min) was significantly longer (p < 0.01) than the normal (4.8 ± 0.2 min) but similar to non-ARF patients (5.4 ± 0.8 min). The bleeding time prolongations in ARF patients were unrelated to platelet concentration. Platelet aggregation induced by ADP and thrombin was normal in both ARF and non-ARF patient groups. The epinephrine response was impaired in one non-ARF patient and in three ARF patients; collagen-induced aggregation was absent in two ARF patients, with a prolonged bleeding time. Levels of VIII:C and vWF in both groups of patients were similar to the normal level, but VIIIR:Ag levels in ARF patients (407 ± 45% of normal) were higher (p < 0.01) than in both non-ARF patients (210% ± 10%) and normal subjects (106% ± 4). The electrophoretic mobility of VIIIR:Ag was abnormal in ARF patients. The prolonged bleeding time in ARF patients appears to result from the qualitative and quantitative VIIIR:Ag defect. β-Thromboglobulin levels were greater (p < 0.01) in ARF patients (87.6 ± 6.9 ng/ml; p < 0.001) than in non-ARF patients (46.2 ± 3.1 ng/ml) or in normal subjects (25.3 ± 2.5 ng/ml p < 0.0001). However, platelet factor 4 plasma levels in ARF patients (18 ± 1.6 ng/ml) did not differ from those in non-ARF patients (15.0 ± 3.0 ng/ml), but both were significantly different from normal (6.1 ± 0.8 ng/ml). Plasma thromboxane B2 (T × B2) levels were not different from normal values in either ARF or non-ARF patients, but 6-keto-PFG1α levels were significantly reduced (p < 0.01) in ARF patients (215 ± 43 pg/ml) compared to normal values (381 ± 34 pg/ml). Non-ARF patients had 6-keto-PGF1α levels (285 ± 111 pg/ml) midway between the normal values and those of ARF patients. Our results suggest that in vivo platelet activation occurs in ARF. ARF patients have quantitative and qualitative platelet defects that may contribute to thrombotic and hemorrhagic complications." @default.
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• W2018144611 date "1987-08-01" @default.
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• W2018144611 title "Platelet function in acute respiratory failure" @default.
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• W2018144611 doi "https://doi.org/10.1002/ajh.2830250404" @default.
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