FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018146220> ?p ?o ?g. }

• W2018146220 endingPage "790" @default.
• W2018146220 startingPage "782" @default.
• W2018146220 abstract "Umbilical cord blood (UCB) is now widely accepted as a source of stem cells in patients with malignant hematologic and genetic disorders. We have recently reported that in a series of 30 pediatric UCB transplant recipients comparable outcome to that anticipated with other unrelated stem cell sources. In our series, however, the probability of GVHD for grade III-IV was 9% and no UCB recipient developed chronic GVHD. The reason for the low incidence of GVHD after UCB transplantation is not fully understood. Because functional NK cells are among the first population of lymphocytes to be detected in UCB transplant recipients, 2 months post-transplant on average, we wanted to establish whether NK cells could be implicated in reducing the risk of GVHD. Here, we confirm that early NK cells detected in UCB transplant recipients activate the granzyme/perforin lytic pathway and, in addition, they can mediate Fas/Fas ligand (FasL) activity, a finding not previously reported. Both pathways develop simultaneously and are detectable months before the other lymphocytes, notably CD8 are fully functional. Our contention, therefore, is that the low GVHD observed in UCB recipients may be partially due to early NK cells." @default.
• W2018146220 created "2016-06-24" @default.
• W2018146220 creator A5008703987 @default.
• W2018146220 creator A5041522628 @default.
• W2018146220 creator A5069354593 @default.
• W2018146220 creator A5089160405 @default.
• W2018146220 date "2001-08-01" @default.
• W2018146220 modified "2023-10-06" @default.
• W2018146220 title "NK cells recover early and mediate cytotoxicity via perforin/granzyme and Fas/FasL pathways in umbilical cord blood recipients" @default.
• W2018146220 cites W117480127 @default.
• W2018146220 cites W1460775 @default.
• W2018146220 cites W1619039200 @default.
• W2018146220 cites W173844952 @default.
• W2018146220 cites W1963907229 @default.
• W2018146220 cites W1965480743 @default.
• W2018146220 cites W1977727186 @default.
• W2018146220 cites W1981668042 @default.
• W2018146220 cites W2006641064 @default.
• W2018146220 cites W2007458001 @default.
• W2018146220 cites W2008930096 @default.
• W2018146220 cites W2025128734 @default.
• W2018146220 cites W2034367373 @default.
• W2018146220 cites W2040538634 @default.
• W2018146220 cites W2042464381 @default.
• W2018146220 cites W2053315217 @default.
• W2018146220 cites W2067308312 @default.
• W2018146220 cites W2085516849 @default.
• W2018146220 cites W2085583663 @default.
• W2018146220 cites W2091153543 @default.
• W2018146220 cites W2094309285 @default.
• W2018146220 cites W2107023017 @default.
• W2018146220 cites W2127340198 @default.
• W2018146220 cites W2130317175 @default.
• W2018146220 cites W2202303746 @default.
• W2018146220 cites W2313467323 @default.
• W2018146220 cites W2323930083 @default.
• W2018146220 cites W2330713242 @default.
• W2018146220 cites W2333162405 @default.
• W2018146220 cites W4234848807 @default.
• W2018146220 cites W94635446 @default.
• W2018146220 doi "https://doi.org/10.1016/s0198-8859(01)00275-0" @default.
• W2018146220 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11476901" @default.
• W2018146220 hasPublicationYear "2001" @default.
• W2018146220 type Work @default.
• W2018146220 sameAs 2018146220 @default.
• W2018146220 citedByCount "47" @default.
• W2018146220 countsByYear W20181462202012 @default.
• W2018146220 countsByYear W20181462202013 @default.
• W2018146220 countsByYear W20181462202015 @default.
• W2018146220 countsByYear W20181462202016 @default.
• W2018146220 countsByYear W20181462202017 @default.
• W2018146220 countsByYear W20181462202018 @default.
• W2018146220 countsByYear W20181462202021 @default.
• W2018146220 countsByYear W20181462202022 @default.
• W2018146220 crossrefType "journal-article" @default.
• W2018146220 hasAuthorship W2018146220A5008703987 @default.
• W2018146220 hasAuthorship W2018146220A5041522628 @default.
• W2018146220 hasAuthorship W2018146220A5069354593 @default.
• W2018146220 hasAuthorship W2018146220A5089160405 @default.
• W2018146220 hasConcept C154317977 @default.
• W2018146220 hasConcept C167672396 @default.
• W2018146220 hasConcept C182615771 @default.
• W2018146220 hasConcept C183193105 @default.
• W2018146220 hasConcept C190283241 @default.
• W2018146220 hasConcept C202751555 @default.
• W2018146220 hasConcept C203014093 @default.
• W2018146220 hasConcept C2522874641 @default.
• W2018146220 hasConcept C2776062744 @default.
• W2018146220 hasConcept C2776955114 @default.
• W2018146220 hasConcept C2780380082 @default.
• W2018146220 hasConcept C2780914630 @default.
• W2018146220 hasConcept C28328180 @default.
• W2018146220 hasConcept C2908647359 @default.
• W2018146220 hasConcept C31573885 @default.
• W2018146220 hasConcept C55493867 @default.
• W2018146220 hasConcept C66008609 @default.
• W2018146220 hasConcept C71924100 @default.
• W2018146220 hasConcept C86803240 @default.
• W2018146220 hasConcept C8891405 @default.
• W2018146220 hasConcept C95444343 @default.
• W2018146220 hasConcept C99454951 @default.
• W2018146220 hasConceptScore W2018146220C154317977 @default.
• W2018146220 hasConceptScore W2018146220C167672396 @default.
• W2018146220 hasConceptScore W2018146220C182615771 @default.
• W2018146220 hasConceptScore W2018146220C183193105 @default.
• W2018146220 hasConceptScore W2018146220C190283241 @default.
• W2018146220 hasConceptScore W2018146220C202751555 @default.
• W2018146220 hasConceptScore W2018146220C203014093 @default.
• W2018146220 hasConceptScore W2018146220C2522874641 @default.
• W2018146220 hasConceptScore W2018146220C2776062744 @default.
• W2018146220 hasConceptScore W2018146220C2776955114 @default.
• W2018146220 hasConceptScore W2018146220C2780380082 @default.
• W2018146220 hasConceptScore W2018146220C2780914630 @default.
• W2018146220 hasConceptScore W2018146220C28328180 @default.
• W2018146220 hasConceptScore W2018146220C2908647359 @default.
• W2018146220 hasConceptScore W2018146220C31573885 @default.
• W2018146220 hasConceptScore W2018146220C55493867 @default.
• W2018146220 hasConceptScore W2018146220C66008609 @default.

• next