FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018152023> ?p ?o ?g. }

• W2018152023 endingPage "645" @default.
• W2018152023 startingPage "638" @default.
• W2018152023 abstract "A subgroup of patients with pseudoachondroplasia (PSACH) and multiple epiphyseal dysplasia (MED) have been found to harbor mutations within the cartilage oligomeric matrix protein (COMP) gene. These two diseases are autosomal dominant disorders that are characterized by an early onset of osteoarthritis (OA). The COMP gene is expressed primarily in chondrocytes in articular cartilage as well as in tendon and ligament. Therefore, control over tissue specific COMP expression may be an important aspect in cartilage biology. To begin an analysis of the regulation of COMP expression, we have cloned, sequenced and characterized the entire genomic clone for mouse COMP that includes the COMP promoter.The COMP coding region spans 19 exons over approximately 8.4 kb of DNA. The arrangement and size of the exons have a remarkable similarity to those of the human COMP genomic sequence, indicating a significant degree of genomic conservation. Analysis of a 453 basepair region of the putative COMP promoter reveals two strong transcriptional repressor elements located between position -356 and -304 and between -251 and -180, relative to the start site for transcription. These repressor elements down-regulate transcription from the promoter in a broad spectrum of cell lines. Removal of the repressor DNA sequence from the COMP promoter leads to significant enhancement in transcriptional activity, indicating that this region acts in a dominant manner to transcriptional activators located more proximal to the start site of transcription. This region also represses transcription when linked to a heterologous promoter.This repressor region probably down-regulates transcription from the COMP promoter in vivo. It may help to repress transcription of COMP in non-cartilaginous tissues and/or may aid in the expression of COMP to the appropriate level in tissues such as cartilage, tendon and ligament." @default.
• W2018152023 created "2016-06-24" @default.
• W2018152023 creator A5019577363 @default.
• W2018152023 creator A5039303466 @default.
• W2018152023 creator A5055226052 @default.
• W2018152023 creator A5057499766 @default.
• W2018152023 creator A5083757203 @default.
• W2018152023 date "2002-08-01" @default.
• W2018152023 modified "2023-09-27" @default.
• W2018152023 title "The murine COMP (cartilage oligomeric matrix protein) promoter contains a potent transcriptional repressor region" @default.
• W2018152023 cites W1550768646 @default.
• W2018152023 cites W1605960013 @default.
• W2018152023 cites W1910940147 @default.
• W2018152023 cites W1969234002 @default.
• W2018152023 cites W1969366516 @default.
• W2018152023 cites W1971345463 @default.
• W2018152023 cites W1978041642 @default.
• W2018152023 cites W1980312552 @default.
• W2018152023 cites W1992994796 @default.
• W2018152023 cites W1993670774 @default.
• W2018152023 cites W2005259839 @default.
• W2018152023 cites W2008380011 @default.
• W2018152023 cites W2023881097 @default.
• W2018152023 cites W2024548988 @default.
• W2018152023 cites W2025853974 @default.
• W2018152023 cites W2029774675 @default.
• W2018152023 cites W2051370951 @default.
• W2018152023 cites W2069262765 @default.
• W2018152023 cites W2080446840 @default.
• W2018152023 cites W2082514280 @default.
• W2018152023 cites W2108253100 @default.
• W2018152023 cites W2158691006 @default.
• W2018152023 cites W2170341904 @default.
• W2018152023 cites W3120415379 @default.
• W2018152023 doi "https://doi.org/10.1053/joca.2002.0532" @default.
• W2018152023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12479386" @default.
• W2018152023 hasPublicationYear "2002" @default.
• W2018152023 type Work @default.
• W2018152023 sameAs 2018152023 @default.
• W2018152023 citedByCount "9" @default.
• W2018152023 countsByYear W20181520232013 @default.
• W2018152023 countsByYear W20181520232015 @default.
• W2018152023 countsByYear W20181520232016 @default.
• W2018152023 crossrefType "journal-article" @default.
• W2018152023 hasAuthorship W2018152023A5019577363 @default.
• W2018152023 hasAuthorship W2018152023A5039303466 @default.
• W2018152023 hasAuthorship W2018152023A5055226052 @default.
• W2018152023 hasAuthorship W2018152023A5057499766 @default.
• W2018152023 hasAuthorship W2018152023A5083757203 @default.
• W2018152023 hasBestOaLocation W20181520231 @default.
• W2018152023 hasConcept C101762097 @default.
• W2018152023 hasConcept C104317684 @default.
• W2018152023 hasConcept C138885662 @default.
• W2018152023 hasConcept C142724271 @default.
• W2018152023 hasConcept C150194340 @default.
• W2018152023 hasConcept C153911025 @default.
• W2018152023 hasConcept C158448853 @default.
• W2018152023 hasConcept C179926584 @default.
• W2018152023 hasConcept C204787440 @default.
• W2018152023 hasConcept C2776164576 @default.
• W2018152023 hasConcept C2778232976 @default.
• W2018152023 hasConcept C36823959 @default.
• W2018152023 hasConcept C41895202 @default.
• W2018152023 hasConcept C54355233 @default.
• W2018152023 hasConcept C71924100 @default.
• W2018152023 hasConcept C86339819 @default.
• W2018152023 hasConcept C86803240 @default.
• W2018152023 hasConceptScore W2018152023C101762097 @default.
• W2018152023 hasConceptScore W2018152023C104317684 @default.
• W2018152023 hasConceptScore W2018152023C138885662 @default.
• W2018152023 hasConceptScore W2018152023C142724271 @default.
• W2018152023 hasConceptScore W2018152023C150194340 @default.
• W2018152023 hasConceptScore W2018152023C153911025 @default.
• W2018152023 hasConceptScore W2018152023C158448853 @default.
• W2018152023 hasConceptScore W2018152023C179926584 @default.
• W2018152023 hasConceptScore W2018152023C204787440 @default.
• W2018152023 hasConceptScore W2018152023C2776164576 @default.
• W2018152023 hasConceptScore W2018152023C2778232976 @default.
• W2018152023 hasConceptScore W2018152023C36823959 @default.
• W2018152023 hasConceptScore W2018152023C41895202 @default.
• W2018152023 hasConceptScore W2018152023C54355233 @default.
• W2018152023 hasConceptScore W2018152023C71924100 @default.
• W2018152023 hasConceptScore W2018152023C86339819 @default.
• W2018152023 hasConceptScore W2018152023C86803240 @default.
• W2018152023 hasIssue "8" @default.
• W2018152023 hasLocation W20181520231 @default.
• W2018152023 hasLocation W20181520232 @default.
• W2018152023 hasOpenAccess W2018152023 @default.
• W2018152023 hasPrimaryLocation W20181520231 @default.
• W2018152023 hasRelatedWork W1567451703 @default.
• W2018152023 hasRelatedWork W2009966535 @default.
• W2018152023 hasRelatedWork W2025851750 @default.
• W2018152023 hasRelatedWork W2039352533 @default.
• W2018152023 hasRelatedWork W2080865520 @default.
• W2018152023 hasRelatedWork W2088889402 @default.
• W2018152023 hasRelatedWork W2121777152 @default.
• W2018152023 hasRelatedWork W2168467210 @default.
• W2018152023 hasRelatedWork W2917404003 @default.

• next