FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018164611> ?p ?o ?g. }

• W2018164611 endingPage "423" @default.
• W2018164611 startingPage "412" @default.
• W2018164611 abstract "Neuronal survival in the cochlear nucleus of young animals is regulated by afferent activity. Removal or blockade of nerve VIII input results in the death of 20–40% of neurons in the cochlear nucleus, nucleus magnocellularis (NM), of the 10–14 days posthatch chick. Neuronal death in NM is preceded by complete failure of protein synthesis and degradation of ribosomes. In addition, there is a biphasic change in the immunoreactivity of ribosomes for a monoclonal antiribosomal RNA antibody, Y10B. Initially, the entire population of afferentdeprived NM neurons loses Y10B immunoreactivity, but, after 6 or 12 hours of afferent deprivation, lack of Y10B immunoreactivity specifically marks dying NM neurons. Whether RNA synthesis is also altered in afferent-deprived NM neurons has not previously been studied. To determine whether RNA synthesis in NM neurons is regulated by loss of afferent activity, we injected chicks with 3H-uridine following unilateral cochlea removal and measured the incorporation of RNA precursor with tissue autoradiography. As early as 1 hour after cochlea removal, there was a significant decrease in 3H-uridine incorporation by afferent-deprived NM neurons. After longer periods of afferent deprivation (6 or 12 hours), the majority of dying NM neurons (marked by loss of Y10B immunoreactivity) fail to incorporate RNA precursor. Six or 12 hours following cochlea removal, the subpopulation of surviving NM neurons incorporates 3H-uridine at increased levels over those observed 1 or 3 hours after cochlea removal. These findings suggest that nuclear function is regulated by afferent synaptic activity and that failure of RNA synthesis occurs early in the cell death process. © 1995 Wiley-Liss, Inc." @default.
• W2018164611 created "2016-06-24" @default.
• W2018164611 creator A5012988440 @default.
• W2018164611 creator A5020597717 @default.
• W2018164611 creator A5078826238 @default.
• W2018164611 date "1995-08-28" @default.
• W2018164611 modified "2023-10-18" @default.
• W2018164611 title "Afferent influences on brainstem auditory nuclei of the chicken: Regulation of transcriptional activity followiqg cochlea removal" @default.
• W2018164611 cites W1589415602 @default.
• W2018164611 cites W1596419519 @default.
• W2018164611 cites W1812145161 @default.
• W2018164611 cites W1880069936 @default.
• W2018164611 cites W1963846828 @default.
• W2018164611 cites W1965985015 @default.
• W2018164611 cites W1969942058 @default.
• W2018164611 cites W1972618659 @default.
• W2018164611 cites W1972765329 @default.
• W2018164611 cites W1974710821 @default.
• W2018164611 cites W1986380368 @default.
• W2018164611 cites W1993359268 @default.
• W2018164611 cites W1995793875 @default.
• W2018164611 cites W1999314140 @default.
• W2018164611 cites W2000269122 @default.
• W2018164611 cites W2003054104 @default.
• W2018164611 cites W2005163062 @default.
• W2018164611 cites W2005182680 @default.
• W2018164611 cites W2016889455 @default.
• W2018164611 cites W2022781130 @default.
• W2018164611 cites W2024520731 @default.
• W2018164611 cites W2029737040 @default.
• W2018164611 cites W2042568710 @default.
• W2018164611 cites W2057621456 @default.
• W2018164611 cites W2059852978 @default.
• W2018164611 cites W2062657095 @default.
• W2018164611 cites W2089624538 @default.
• W2018164611 cites W2093605386 @default.
• W2018164611 cites W2094795873 @default.
• W2018164611 cites W2099309722 @default.
• W2018164611 cites W2101448581 @default.
• W2018164611 cites W2106560349 @default.
• W2018164611 cites W2118176716 @default.
• W2018164611 cites W2118785340 @default.
• W2018164611 cites W2122358271 @default.
• W2018164611 cites W2128556377 @default.
• W2018164611 cites W2134205510 @default.
• W2018164611 cites W2146346171 @default.
• W2018164611 cites W2169548388 @default.
• W2018164611 cites W2170413042 @default.
• W2018164611 cites W2232222039 @default.
• W2018164611 cites W2340073049 @default.
• W2018164611 cites W2414148157 @default.
• W2018164611 doi "https://doi.org/10.1002/cne.903590305" @default.
• W2018164611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7499538" @default.
• W2018164611 hasPublicationYear "1995" @default.
• W2018164611 type Work @default.
• W2018164611 sameAs 2018164611 @default.
• W2018164611 citedByCount "24" @default.
• W2018164611 countsByYear W20181646112013 @default.
• W2018164611 countsByYear W20181646112014 @default.
• W2018164611 countsByYear W20181646112015 @default.
• W2018164611 countsByYear W20181646112016 @default.
• W2018164611 countsByYear W20181646112020 @default.
• W2018164611 crossrefType "journal-article" @default.
• W2018164611 hasAuthorship W2018164611A5012988440 @default.
• W2018164611 hasAuthorship W2018164611A5020597717 @default.
• W2018164611 hasAuthorship W2018164611A5078826238 @default.
• W2018164611 hasConcept C104317684 @default.
• W2018164611 hasConcept C134018914 @default.
• W2018164611 hasConcept C169760540 @default.
• W2018164611 hasConcept C185592680 @default.
• W2018164611 hasConcept C2776512019 @default.
• W2018164611 hasConcept C2779263132 @default.
• W2018164611 hasConcept C2780130748 @default.
• W2018164611 hasConcept C2780723820 @default.
• W2018164611 hasConcept C2781259782 @default.
• W2018164611 hasConcept C551621295 @default.
• W2018164611 hasConcept C55493867 @default.
• W2018164611 hasConcept C67705224 @default.
• W2018164611 hasConcept C86803240 @default.
• W2018164611 hasConcept C95444343 @default.
• W2018164611 hasConceptScore W2018164611C104317684 @default.
• W2018164611 hasConceptScore W2018164611C134018914 @default.
• W2018164611 hasConceptScore W2018164611C169760540 @default.
• W2018164611 hasConceptScore W2018164611C185592680 @default.
• W2018164611 hasConceptScore W2018164611C2776512019 @default.
• W2018164611 hasConceptScore W2018164611C2779263132 @default.
• W2018164611 hasConceptScore W2018164611C2780130748 @default.
• W2018164611 hasConceptScore W2018164611C2780723820 @default.
• W2018164611 hasConceptScore W2018164611C2781259782 @default.
• W2018164611 hasConceptScore W2018164611C551621295 @default.
• W2018164611 hasConceptScore W2018164611C55493867 @default.
• W2018164611 hasConceptScore W2018164611C67705224 @default.
• W2018164611 hasConceptScore W2018164611C86803240 @default.
• W2018164611 hasConceptScore W2018164611C95444343 @default.
• W2018164611 hasIssue "3" @default.
• W2018164611 hasLocation W20181646111 @default.
• W2018164611 hasLocation W20181646112 @default.
• W2018164611 hasOpenAccess W2018164611 @default.

• next