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- W2018167944 abstract "Recent work exploring the use of high-molecular weight alcohols to treat essential tremor (ET) has identified octanoic acid as a potential novel tremor-suppressing agent. We used an established harmaline-based mouse model of ET to compare tremor suppression by 1-octanol and octanoic acid. The dose-related effect on digitized motion power within the tremor bandwidth as a fraction of overall motion power was analyzed. Both 1-octanol and octanoic acid provided significant reductions in harmaline tremor. An 8-carbon alkyl alcohol and carboxylic acid each suppress tremor in a pre-clinical mouse model of ET. Further studies are warranted to determine the safety and efficacy of such agents in humans with ET." @default.
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- W2018167944 date "2012-03-28" @default.
- W2018167944 modified "2023-09-24" @default.
- W2018167944 title "Octanoic Acid Suppresses Harmaline-Induced Tremor in Mouse Model of Essential Tremor" @default.
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- W2018167944 doi "https://doi.org/10.1007/s13311-012-0121-1" @default.
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