FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018172685> ?p ?o ?g. }

• W2018172685 endingPage "118" @default.
• W2018172685 startingPage "107" @default.
• W2018172685 abstract "Activation of toll-like receptors (TLR) in articular chondrocytes has been reported to increase the catabolic compartment, leading to matrix degradation, while the main consequence of TLR activation in monocytic cells is the expression and secretion of components of the innate immune response, particularly that of inflammatory cytokines. The objective of the work reported here was to obtain a more complete picture of the response repertoire of articular chondrocytes to TLR activation. Mass spectrometry was used to analyse the secretome of stimulated and unstimulated cells. Characterization of TLR expression in rat articular chondrocytes by RT/PCR indicated that TLR4 was the major receptor form. Exposure of these cells to lipopolysaccharide (LPS), the well-characterized TLR4 ligand, induced production not only of the matrix metalloproteinases MMP3 and 13, but also of components traditionally associated with the innate immune response, such as the complement components C1r, C3 and complement factor B, long pentraxin-3 and osteoglycin. Neither TNF-α nor IL-1 was detectable in culture media following exposure to LPS. One of the most prominently-induced proteins was the chitinase-like protein, Chi3L1, linking its expression to the innate immune response repertoire of articular chondrocytes. In intact femoral heads, LPS induced expression of Chi3L1 in chondrocytes close to the articular surface, suggesting that only these cells mount a stress response to LPS. Thus articular chondrocytes have a capacity to respond to TLR activation, which results in the expression of matrix metalloproteases as well as subsets of components of the innate immune response without significant increases in the production of inflammatory cytokines. This could influence the erosive processes leading to cartilage degeneration as well as the repair of damaged matrix." @default.
• W2018172685 created "2016-06-24" @default.
• W2018172685 creator A5028696068 @default.
• W2018172685 creator A5044498701 @default.
• W2018172685 creator A5057948072 @default.
• W2018172685 creator A5083004835 @default.
• W2018172685 date "2008-03-01" @default.
• W2018172685 modified "2023-10-18" @default.
• W2018172685 title "Proteomic analysis of the LPS-induced stress response in rat chondrocytes reveals induction of innate immune response components in articular cartilage" @default.
• W2018172685 cites W1488196937 @default.
• W2018172685 cites W1507151313 @default.
• W2018172685 cites W1568609804 @default.
• W2018172685 cites W17752340 @default.
• W2018172685 cites W1828930947 @default.
• W2018172685 cites W1927941125 @default.
• W2018172685 cites W1929515229 @default.
• W2018172685 cites W1963802005 @default.
• W2018172685 cites W1983345459 @default.
• W2018172685 cites W1986442052 @default.
• W2018172685 cites W1987383242 @default.
• W2018172685 cites W1991731944 @default.
• W2018172685 cites W1992245975 @default.
• W2018172685 cites W1996268835 @default.
• W2018172685 cites W2003236418 @default.
• W2018172685 cites W2003562072 @default.
• W2018172685 cites W2004465286 @default.
• W2018172685 cites W2006721421 @default.
• W2018172685 cites W2014695403 @default.
• W2018172685 cites W2016643048 @default.
• W2018172685 cites W2029837774 @default.
• W2018172685 cites W2030237203 @default.
• W2018172685 cites W2036747221 @default.
• W2018172685 cites W2036760454 @default.
• W2018172685 cites W2038975231 @default.
• W2018172685 cites W2042664285 @default.
• W2018172685 cites W2047334057 @default.
• W2018172685 cites W2056526793 @default.
• W2018172685 cites W2057491978 @default.
• W2018172685 cites W2058774374 @default.
• W2018172685 cites W2061626698 @default.
• W2018172685 cites W2067840722 @default.
• W2018172685 cites W2070855107 @default.
• W2018172685 cites W2081719489 @default.
• W2018172685 cites W2083479832 @default.
• W2018172685 cites W2097457307 @default.
• W2018172685 cites W2097972394 @default.
• W2018172685 cites W2100571347 @default.
• W2018172685 cites W2114345620 @default.
• W2018172685 cites W2118538079 @default.
• W2018172685 cites W2124816671 @default.
• W2018172685 cites W2126659405 @default.
• W2018172685 cites W2127844945 @default.
• W2018172685 cites W2129491391 @default.
• W2018172685 cites W2130459735 @default.
• W2018172685 cites W2130932880 @default.
• W2018172685 cites W2133449490 @default.
• W2018172685 cites W2151671649 @default.
• W2018172685 cites W2170726898 @default.
• W2018172685 cites W2170983988 @default.
• W2018172685 doi "https://doi.org/10.1016/j.matbio.2007.09.009" @default.
• W2018172685 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18023983" @default.
• W2018172685 hasPublicationYear "2008" @default.
• W2018172685 type Work @default.
• W2018172685 sameAs 2018172685 @default.
• W2018172685 citedByCount "72" @default.
• W2018172685 countsByYear W20181726852012 @default.
• W2018172685 countsByYear W20181726852013 @default.
• W2018172685 countsByYear W20181726852014 @default.
• W2018172685 countsByYear W20181726852015 @default.
• W2018172685 countsByYear W20181726852016 @default.
• W2018172685 countsByYear W20181726852017 @default.
• W2018172685 countsByYear W20181726852018 @default.
• W2018172685 countsByYear W20181726852019 @default.
• W2018172685 countsByYear W20181726852020 @default.
• W2018172685 countsByYear W20181726852021 @default.
• W2018172685 countsByYear W20181726852022 @default.
• W2018172685 countsByYear W20181726852023 @default.
• W2018172685 crossrefType "journal-article" @default.
• W2018172685 hasAuthorship W2018172685A5028696068 @default.
• W2018172685 hasAuthorship W2018172685A5044498701 @default.
• W2018172685 hasAuthorship W2018172685A5057948072 @default.
• W2018172685 hasAuthorship W2018172685A5083004835 @default.
• W2018172685 hasConcept C105702510 @default.
• W2018172685 hasConcept C111684460 @default.
• W2018172685 hasConcept C136449434 @default.
• W2018172685 hasConcept C171279029 @default.
• W2018172685 hasConcept C185592680 @default.
• W2018172685 hasConcept C203014093 @default.
• W2018172685 hasConcept C2776070231 @default.
• W2018172685 hasConcept C2776709828 @default.
• W2018172685 hasConcept C2778754761 @default.
• W2018172685 hasConcept C2780550940 @default.
• W2018172685 hasConcept C86803240 @default.
• W2018172685 hasConcept C8891405 @default.
• W2018172685 hasConcept C95444343 @default.
• W2018172685 hasConceptScore W2018172685C105702510 @default.
• W2018172685 hasConceptScore W2018172685C111684460 @default.
• W2018172685 hasConceptScore W2018172685C136449434 @default.

• next