Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018173352> ?p ?o ?g. }
- W2018173352 endingPage "922" @default.
- W2018173352 startingPage "914" @default.
- W2018173352 abstract "Primary human keratinocytes (PHKs) are known to express the EP3 subtype of prostaglandin E2 receptor. To better understand the role of EP3 receptors in regulating epidermal function, we characterized their expression, localization, and signaling effects in human skin. Three different splice variants of the EP3 receptor (EP3A1, EP3C, and EP3D) were found to be expressed. Immunohistochemical analysis of human skin demonstrated that EP3 receptors were most prominently expressed in the basal and lower spinous layers of the epidermis. The EP3 receptor agonist sulprostone was then used to examine EP3 receptor-dependent keratinocyte signaling pathways and functional effects. We observed that sulprostone inhibits keratinocyte growth at doses between 0.02 and 2 nM and induces sn-1,2-diacylglycerol (DAG) and ceramide production. Concurrent expression of the cell-cycle inhibitory protein p21WAF1 also occurred. These data suggest that EP3 receptors produce epidermal growth inhibition through the action of DAG and ceramide second messengers." @default.
- W2018173352 created "2016-06-24" @default.
- W2018173352 creator A5016078181 @default.
- W2018173352 creator A5028890075 @default.
- W2018173352 creator A5034123671 @default.
- W2018173352 creator A5048524904 @default.
- W2018173352 creator A5091311739 @default.
- W2018173352 date "2005-11-07" @default.
- W2018173352 modified "2023-10-12" @default.
- W2018173352 title "The EP3 receptor stimulates ceramide and diacylglycerol release and inhibits growth of primary keratinocytes" @default.
- W2018173352 cites W1502567507 @default.
- W2018173352 cites W1573232618 @default.
- W2018173352 cites W1573913384 @default.
- W2018173352 cites W1811443163 @default.
- W2018173352 cites W1977394772 @default.
- W2018173352 cites W1990747124 @default.
- W2018173352 cites W1992466621 @default.
- W2018173352 cites W1994249917 @default.
- W2018173352 cites W1994467655 @default.
- W2018173352 cites W2000693690 @default.
- W2018173352 cites W2002854300 @default.
- W2018173352 cites W2003436829 @default.
- W2018173352 cites W2013690042 @default.
- W2018173352 cites W2022188188 @default.
- W2018173352 cites W2024310306 @default.
- W2018173352 cites W2036733592 @default.
- W2018173352 cites W2039359884 @default.
- W2018173352 cites W2040528315 @default.
- W2018173352 cites W2053845602 @default.
- W2018173352 cites W2060592309 @default.
- W2018173352 cites W2063136699 @default.
- W2018173352 cites W2064189226 @default.
- W2018173352 cites W2077481637 @default.
- W2018173352 cites W2084615605 @default.
- W2018173352 cites W2088839349 @default.
- W2018173352 cites W2108149965 @default.
- W2018173352 cites W2109549744 @default.
- W2018173352 cites W2116484214 @default.
- W2018173352 cites W2122802846 @default.
- W2018173352 cites W2125471013 @default.
- W2018173352 cites W2128057279 @default.
- W2018173352 cites W2129746956 @default.
- W2018173352 cites W2131224195 @default.
- W2018173352 cites W2136049881 @default.
- W2018173352 cites W2137079733 @default.
- W2018173352 cites W2156924387 @default.
- W2018173352 cites W2188089527 @default.
- W2018173352 cites W2339856804 @default.
- W2018173352 cites W4235881998 @default.
- W2018173352 cites W83545051 @default.
- W2018173352 doi "https://doi.org/10.1111/j.1600-0625.2005.00381.x" @default.
- W2018173352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16274459" @default.
- W2018173352 hasPublicationYear "2005" @default.
- W2018173352 type Work @default.
- W2018173352 sameAs 2018173352 @default.
- W2018173352 citedByCount "33" @default.
- W2018173352 countsByYear W20181733522012 @default.
- W2018173352 countsByYear W20181733522013 @default.
- W2018173352 countsByYear W20181733522014 @default.
- W2018173352 countsByYear W20181733522018 @default.
- W2018173352 countsByYear W20181733522019 @default.
- W2018173352 countsByYear W20181733522020 @default.
- W2018173352 countsByYear W20181733522021 @default.
- W2018173352 countsByYear W20181733522022 @default.
- W2018173352 countsByYear W20181733522023 @default.
- W2018173352 crossrefType "journal-article" @default.
- W2018173352 hasAuthorship W2018173352A5016078181 @default.
- W2018173352 hasAuthorship W2018173352A5028890075 @default.
- W2018173352 hasAuthorship W2018173352A5034123671 @default.
- W2018173352 hasAuthorship W2018173352A5048524904 @default.
- W2018173352 hasAuthorship W2018173352A5091311739 @default.
- W2018173352 hasConcept C105702510 @default.
- W2018173352 hasConcept C163235415 @default.
- W2018173352 hasConcept C170493617 @default.
- W2018173352 hasConcept C178592051 @default.
- W2018173352 hasConcept C180899940 @default.
- W2018173352 hasConcept C190283241 @default.
- W2018173352 hasConcept C195794163 @default.
- W2018173352 hasConcept C2776458125 @default.
- W2018173352 hasConcept C2777074287 @default.
- W2018173352 hasConcept C2777851122 @default.
- W2018173352 hasConcept C2778938600 @default.
- W2018173352 hasConcept C36020004 @default.
- W2018173352 hasConcept C54355233 @default.
- W2018173352 hasConcept C55493867 @default.
- W2018173352 hasConcept C62478195 @default.
- W2018173352 hasConcept C81885089 @default.
- W2018173352 hasConcept C86803240 @default.
- W2018173352 hasConcept C95444343 @default.
- W2018173352 hasConceptScore W2018173352C105702510 @default.
- W2018173352 hasConceptScore W2018173352C163235415 @default.
- W2018173352 hasConceptScore W2018173352C170493617 @default.
- W2018173352 hasConceptScore W2018173352C178592051 @default.
- W2018173352 hasConceptScore W2018173352C180899940 @default.
- W2018173352 hasConceptScore W2018173352C190283241 @default.
- W2018173352 hasConceptScore W2018173352C195794163 @default.
- W2018173352 hasConceptScore W2018173352C2776458125 @default.
- W2018173352 hasConceptScore W2018173352C2777074287 @default.