Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018174911> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2018174911 endingPage "e56014" @default.
- W2018174911 startingPage "e56014" @default.
- W2018174911 abstract "NOD2 is an intracellular pattern recognition receptor that provides innate sensing of bacterial muramyl dipeptide by host cells, such as dendritic cells, macrophages and epithelial cells. While NOD2's role as an innate pathogen sensor is well established, NOD2 is also expressed at low levels in T cells and there are conflicting data as to whether NOD2 plays an intrinsic role in T cell function. Here we show that following adoptive transfer into WT hosts, NOD2−/− OT-I T cells show a small decrease in the number of OVA-specific CD8 T cells recovered at the peak of the response to respiratory influenza virus infection. On the other hand, no such defect was observed upon intranasal immunization with a replication defective adenovirus carrying the OVA epitope recognized by OT-I, or when OVA was delivered with LPS subcutaneously, or when influenza-OVA was delivered intraperitoneally. Thus we observed a selective defect in NOD2-deficient T cell responses only during a live viral infection. Moreover, there was no apparent defect when NOD2−/− OT-I T cells were stimulated in vitro. Finally, this selective defect in recovery of NOD2-deficient CD8 T cells was not observed in a non-transgenic respiratory infection model in which mixed bone marrow chimeras were used such that the NOD2−/− T cells were allowed to develop and respond in a NOD2-sufficient host. Taken together our data indicate that T cell intrinsic NOD2 is not required for CD8 T cell responses to antigen delivered under a variety of conditions in vitro and in vivo. However, CD8 T cells that have developed in the absence of NOD2 show a selective and modest impairment in their response to live respiratory influenza infection." @default.
- W2018174911 created "2016-06-24" @default.
- W2018174911 creator A5039893539 @default.
- W2018174911 creator A5046685448 @default.
- W2018174911 creator A5057038887 @default.
- W2018174911 creator A5070424975 @default.
- W2018174911 creator A5087347803 @default.
- W2018174911 date "2013-02-06" @default.
- W2018174911 modified "2023-09-27" @default.
- W2018174911 title "T Cell Intrinsic NOD2 Is Dispensable for CD8 T Cell Immunity" @default.
- W2018174911 cites W1481208898 @default.
- W2018174911 cites W1975026318 @default.
- W2018174911 cites W2037254336 @default.
- W2018174911 cites W2038143978 @default.
- W2018174911 cites W2075583035 @default.
- W2018174911 cites W2082444399 @default.
- W2018174911 cites W2111900042 @default.
- W2018174911 cites W2131966979 @default.
- W2018174911 cites W2141068458 @default.
- W2018174911 cites W2152744762 @default.
- W2018174911 cites W2154126938 @default.
- W2018174911 cites W2161579012 @default.
- W2018174911 doi "https://doi.org/10.1371/journal.pone.0056014" @default.
- W2018174911 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3566081" @default.
- W2018174911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23405246" @default.
- W2018174911 hasPublicationYear "2013" @default.
- W2018174911 type Work @default.
- W2018174911 sameAs 2018174911 @default.
- W2018174911 citedByCount "11" @default.
- W2018174911 countsByYear W20181749112013 @default.
- W2018174911 countsByYear W20181749112014 @default.
- W2018174911 countsByYear W20181749112018 @default.
- W2018174911 countsByYear W20181749112019 @default.
- W2018174911 countsByYear W20181749112021 @default.
- W2018174911 countsByYear W20181749112022 @default.
- W2018174911 crossrefType "journal-article" @default.
- W2018174911 hasAuthorship W2018174911A5039893539 @default.
- W2018174911 hasAuthorship W2018174911A5046685448 @default.
- W2018174911 hasAuthorship W2018174911A5057038887 @default.
- W2018174911 hasAuthorship W2018174911A5070424975 @default.
- W2018174911 hasAuthorship W2018174911A5087347803 @default.
- W2018174911 hasBestOaLocation W20181749111 @default.
- W2018174911 hasConcept C136449434 @default.
- W2018174911 hasConcept C154317977 @default.
- W2018174911 hasConcept C167672396 @default.
- W2018174911 hasConcept C193419808 @default.
- W2018174911 hasConcept C202751555 @default.
- W2018174911 hasConcept C203014093 @default.
- W2018174911 hasConcept C2776090121 @default.
- W2018174911 hasConcept C2776444769 @default.
- W2018174911 hasConcept C55493867 @default.
- W2018174911 hasConcept C67662055 @default.
- W2018174911 hasConcept C7573103 @default.
- W2018174911 hasConcept C86803240 @default.
- W2018174911 hasConcept C8891405 @default.
- W2018174911 hasConcept C90375314 @default.
- W2018174911 hasConcept C95444343 @default.
- W2018174911 hasConceptScore W2018174911C136449434 @default.
- W2018174911 hasConceptScore W2018174911C154317977 @default.
- W2018174911 hasConceptScore W2018174911C167672396 @default.
- W2018174911 hasConceptScore W2018174911C193419808 @default.
- W2018174911 hasConceptScore W2018174911C202751555 @default.
- W2018174911 hasConceptScore W2018174911C203014093 @default.
- W2018174911 hasConceptScore W2018174911C2776090121 @default.
- W2018174911 hasConceptScore W2018174911C2776444769 @default.
- W2018174911 hasConceptScore W2018174911C55493867 @default.
- W2018174911 hasConceptScore W2018174911C67662055 @default.
- W2018174911 hasConceptScore W2018174911C7573103 @default.
- W2018174911 hasConceptScore W2018174911C86803240 @default.
- W2018174911 hasConceptScore W2018174911C8891405 @default.
- W2018174911 hasConceptScore W2018174911C90375314 @default.
- W2018174911 hasConceptScore W2018174911C95444343 @default.
- W2018174911 hasIssue "2" @default.
- W2018174911 hasLocation W20181749111 @default.
- W2018174911 hasLocation W20181749112 @default.
- W2018174911 hasLocation W20181749113 @default.
- W2018174911 hasLocation W20181749114 @default.
- W2018174911 hasOpenAccess W2018174911 @default.
- W2018174911 hasPrimaryLocation W20181749111 @default.
- W2018174911 hasRelatedWork W1557412924 @default.
- W2018174911 hasRelatedWork W2141330728 @default.
- W2018174911 hasRelatedWork W2163847018 @default.
- W2018174911 hasRelatedWork W2287738525 @default.
- W2018174911 hasRelatedWork W2439417625 @default.
- W2018174911 hasRelatedWork W2464137051 @default.
- W2018174911 hasRelatedWork W2524572457 @default.
- W2018174911 hasRelatedWork W2787280299 @default.
- W2018174911 hasRelatedWork W2884963187 @default.
- W2018174911 hasRelatedWork W3173381879 @default.
- W2018174911 hasVolume "8" @default.
- W2018174911 isParatext "false" @default.
- W2018174911 isRetracted "false" @default.
- W2018174911 magId "2018174911" @default.
- W2018174911 workType "article" @default.