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• W2018176172 abstract "Objective— The purpose of this research was to evaluate the short-term effects of pioglitazone (PIO) on high-density lipoprotein cholesterol (HDL-C) and other metabolic parameters in nondiabetic patients with metabolic syndrome (MetSyn). Methods and Results— Sixty nondiabetic adults with low HDL-C and MetSyn were randomized to PIO or matching placebo for 12 weeks. PIO increased HDL-C by 15% and 14% at 6 and 12 weeks, respectively, compared with placebo ( P <0.001). Changes in HDL-C were correlated to changes in adiponectin ( r =0.34; P =0.01) but not to changes in insulin resistance. PIO did not affect serum triglycerides or low-density lipoprotein (LDL) cholesterol concentrations but reduced the number of small LDL particles by 18% ( P <0.001). PIO reduced median C-reactive protein levels by 31% ( P <0.001) and mean resistin levels by 10% ( P =0.02) while increasing mean serum levels of adiponectin by 111% ( P <0.001) compared with placebo. PIO did not affect weight and modestly decreased insulin resistance. Conclusions— In nondiabetic patients with low HDL-C and MetSyn, PIO significantly raised HDL-C and favorably affected lipoprotein particle size, markers of inflammation, and adipokines without changes in triglycerides, LDL-C, or weight. These results suggest that PIO has direct effects on HDL, which may contribute to its antiatherogenic effects." @default.
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• W2018176172 date "2006-01-01" @default.
• W2018176172 modified "2023-10-16" @default.
• W2018176172 title "Effects of Pioglitazone on Lipoproteins, Inflammatory Markers, and Adipokines in Nondiabetic Patients with Metabolic Syndrome" @default.
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• W2018176172 doi "https://doi.org/10.1161/01.atv.0000195790.24531.4f" @default.
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