Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018182334> ?p ?o ?g. }
- W2018182334 endingPage "1270.e2" @default.
- W2018182334 startingPage "1264" @default.
- W2018182334 abstract "ObjectivesMagnetic resonance imaging has been used to define the neurologic abnormalities in infants with congenital heart disease (CHD), including preoperative injury and delayed brain maturation. The present study used qualitative scoring, cerebral biometry, and diffusion imaging to characterize the preoperative brain abnormalities in infants with CHD, including the identification of regions of greater vulnerability.MethodsA total of 67 infants with CHD had preoperative magnetic resonance imaging scans available for analysis of brain injury using qualitative scoring and brain development using qualitative scoring, metrics, and diffusion imaging.ResultsQualitative abnormalities were common, with 42% of infants having preoperative focal white matter lesions. Infants with CHD had smaller brain measures in the frontal lobe, parietal lobe, cerebellum, and brainstem (P < .001), with the frontal lobe and brainstem displaying the greatest alterations (P < .001). A smaller brain size in the frontal and parietal lobes correlated with delayed white matter microstructure reflected by diffusion imaging.ConclusionsInfants with CHD commonly display brain injury and delayed brain development. Regional alterations in brain size are present, with the frontal lobe and brainstem demonstrating the greatest alterations. This might reflect a combination of developmental vulnerability and regional differences in cerebral circulation. Magnetic resonance imaging has been used to define the neurologic abnormalities in infants with congenital heart disease (CHD), including preoperative injury and delayed brain maturation. The present study used qualitative scoring, cerebral biometry, and diffusion imaging to characterize the preoperative brain abnormalities in infants with CHD, including the identification of regions of greater vulnerability. A total of 67 infants with CHD had preoperative magnetic resonance imaging scans available for analysis of brain injury using qualitative scoring and brain development using qualitative scoring, metrics, and diffusion imaging. Qualitative abnormalities were common, with 42% of infants having preoperative focal white matter lesions. Infants with CHD had smaller brain measures in the frontal lobe, parietal lobe, cerebellum, and brainstem (P < .001), with the frontal lobe and brainstem displaying the greatest alterations (P < .001). A smaller brain size in the frontal and parietal lobes correlated with delayed white matter microstructure reflected by diffusion imaging. Infants with CHD commonly display brain injury and delayed brain development. Regional alterations in brain size are present, with the frontal lobe and brainstem demonstrating the greatest alterations. This might reflect a combination of developmental vulnerability and regional differences in cerebral circulation." @default.
- W2018182334 created "2016-06-24" @default.
- W2018182334 creator A5010954850 @default.
- W2018182334 creator A5013891503 @default.
- W2018182334 creator A5016879313 @default.
- W2018182334 creator A5029831731 @default.
- W2018182334 creator A5057246360 @default.
- W2018182334 creator A5059281499 @default.
- W2018182334 creator A5072261551 @default.
- W2018182334 creator A5086152043 @default.
- W2018182334 creator A5091468331 @default.
- W2018182334 date "2012-06-01" @default.
- W2018182334 modified "2023-10-10" @default.
- W2018182334 title "Regional alterations in cerebral growth exist preoperatively in infants with congenital heart disease" @default.
- W2018182334 cites W1902838673 @default.
- W2018182334 cites W1977425029 @default.
- W2018182334 cites W2004326873 @default.
- W2018182334 cites W2006207700 @default.
- W2018182334 cites W2029838105 @default.
- W2018182334 cites W2037588444 @default.
- W2018182334 cites W2040551145 @default.
- W2018182334 cites W2042862484 @default.
- W2018182334 cites W2052999850 @default.
- W2018182334 cites W2063001897 @default.
- W2018182334 cites W2063320607 @default.
- W2018182334 cites W2068174282 @default.
- W2018182334 cites W2072250943 @default.
- W2018182334 cites W2079141380 @default.
- W2018182334 cites W2079492007 @default.
- W2018182334 cites W2082117755 @default.
- W2018182334 cites W2083193505 @default.
- W2018182334 cites W2086315393 @default.
- W2018182334 cites W2087859772 @default.
- W2018182334 cites W2105478587 @default.
- W2018182334 cites W2105549490 @default.
- W2018182334 cites W2125348285 @default.
- W2018182334 cites W2141245108 @default.
- W2018182334 cites W2152292563 @default.
- W2018182334 cites W2166037419 @default.
- W2018182334 doi "https://doi.org/10.1016/j.jtcvs.2011.10.039" @default.
- W2018182334 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3322305" @default.
- W2018182334 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22143100" @default.
- W2018182334 hasPublicationYear "2012" @default.
- W2018182334 type Work @default.
- W2018182334 sameAs 2018182334 @default.
- W2018182334 citedByCount "79" @default.
- W2018182334 countsByYear W20181823342013 @default.
- W2018182334 countsByYear W20181823342014 @default.
- W2018182334 countsByYear W20181823342015 @default.
- W2018182334 countsByYear W20181823342016 @default.
- W2018182334 countsByYear W20181823342017 @default.
- W2018182334 countsByYear W20181823342018 @default.
- W2018182334 countsByYear W20181823342019 @default.
- W2018182334 countsByYear W20181823342020 @default.
- W2018182334 countsByYear W20181823342021 @default.
- W2018182334 countsByYear W20181823342022 @default.
- W2018182334 countsByYear W20181823342023 @default.
- W2018182334 crossrefType "journal-article" @default.
- W2018182334 hasAuthorship W2018182334A5010954850 @default.
- W2018182334 hasAuthorship W2018182334A5013891503 @default.
- W2018182334 hasAuthorship W2018182334A5016879313 @default.
- W2018182334 hasAuthorship W2018182334A5029831731 @default.
- W2018182334 hasAuthorship W2018182334A5057246360 @default.
- W2018182334 hasAuthorship W2018182334A5059281499 @default.
- W2018182334 hasAuthorship W2018182334A5072261551 @default.
- W2018182334 hasAuthorship W2018182334A5086152043 @default.
- W2018182334 hasAuthorship W2018182334A5091468331 @default.
- W2018182334 hasBestOaLocation W20181823341 @default.
- W2018182334 hasConcept C118552586 @default.
- W2018182334 hasConcept C126322002 @default.
- W2018182334 hasConcept C126838900 @default.
- W2018182334 hasConcept C143409427 @default.
- W2018182334 hasConcept C149550507 @default.
- W2018182334 hasConcept C164705383 @default.
- W2018182334 hasConcept C2777127467 @default.
- W2018182334 hasConcept C2778186239 @default.
- W2018182334 hasConcept C2780074459 @default.
- W2018182334 hasConcept C2781099131 @default.
- W2018182334 hasConcept C2781192897 @default.
- W2018182334 hasConcept C551621295 @default.
- W2018182334 hasConcept C58693492 @default.
- W2018182334 hasConcept C71924100 @default.
- W2018182334 hasConceptScore W2018182334C118552586 @default.
- W2018182334 hasConceptScore W2018182334C126322002 @default.
- W2018182334 hasConceptScore W2018182334C126838900 @default.
- W2018182334 hasConceptScore W2018182334C143409427 @default.
- W2018182334 hasConceptScore W2018182334C149550507 @default.
- W2018182334 hasConceptScore W2018182334C164705383 @default.
- W2018182334 hasConceptScore W2018182334C2777127467 @default.
- W2018182334 hasConceptScore W2018182334C2778186239 @default.
- W2018182334 hasConceptScore W2018182334C2780074459 @default.
- W2018182334 hasConceptScore W2018182334C2781099131 @default.
- W2018182334 hasConceptScore W2018182334C2781192897 @default.
- W2018182334 hasConceptScore W2018182334C551621295 @default.
- W2018182334 hasConceptScore W2018182334C58693492 @default.
- W2018182334 hasConceptScore W2018182334C71924100 @default.
- W2018182334 hasIssue "6" @default.
- W2018182334 hasLocation W20181823341 @default.