FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018184554> ?p ?o ?g. }

• W2018184554 endingPage "1660" @default.
• W2018184554 startingPage "1651" @default.
• W2018184554 abstract "The aim of this study was to determine whether different signal transduction mechanisms underlie the Ca 2+ sensitizing effects of guanosine 5′‐ O ‐(3‐thiotriphosphate) (GTP γ S) and receptor agonists on β‐escin‐skinned smooth muscle of rabbit mesenteric artery. In the homogenate of the β‐escin‐skinned arterial strip, C3 exoenzyme of Clostridium botulinum catalyzed the [ 32 P]‐ADP‐ribosylation of only one protein that had the same molecular mass as the protein detected in Western blots with anti‐ rho p21 antibody. Pretreatment of preparations with C3 resulted in great inhibition of GTP γ S‐induced Ca 2+ sensitization, although the effect of GTP γ S at higher concentrations (30 μ M ) was not completely blocked by this treatment. In contrast, the enhancement by phenylephrine and histamine, in the presence of guanosine 5′‐triphosphate, of the Ca 2+ ‐induced contraction was not affected by C3 pretreatment. The protein kinase C (PKC) inhibitors calphostin C and staurosporine completely eliminated the enhancement by phorbol ester 12,13‐dibutyrate of the Ca 2+ ‐induced contraction. However, these PKC inhibitors had no effect on GTP γ S‐ and receptor agonist‐induced Ca 2+ sensitization. The tyrosine kinase inhibitors genistein and tyrphostin 25 caused an irreversible and complete block of the enhancement by GTP γ S of the Ca 2+ ‐induced contraction without affecting this Ca 2+ contraction. The inactive genistein analogue daidzein did not modify the effect of GTP γ S. The Ca 2+ sensitizing effects of phenylephrine and histamine were also blocked by these tyrosine kinase inhibitors. These results suggest that rho p21 predominantly mediates GTP γ S‐induced Ca 2+ sensitization of β‐escin‐skinned smooth muscle of rabbit mesenteric artery, while the Ca 2+ sensitizing actions of heterotrimeric G protein‐coupled receptor agonists do not involve this small G protein. However, it seems that tyrosine phosphorylation, but not PKC activation, plays an important role in both of the rho p21 protein‐ and heterotrimeric G protein‐mediated Ca 2+ sensitization mechanisms." @default.
• W2018184554 created "2016-06-24" @default.
• W2018184554 creator A5004419638 @default.
• W2018184554 creator A5010531715 @default.
• W2018184554 creator A5027728106 @default.
• W2018184554 creator A5038163394 @default.
• W2018184554 creator A5038192407 @default.
• W2018184554 creator A5038246750 @default.
• W2018184554 creator A5059316181 @default.
• W2018184554 creator A5064448710 @default.
• W2018184554 date "1998-12-01" @default.
• W2018184554 modified "2023-10-18" @default.
• W2018184554 title "Tyrosine phosphorylation as a convergent pathway of heterotrimeric G protein‐ and <i>rho</i> protein‐mediated Ca²⁺ sensitization of smooth muscle of rabbit mesenteric artery" @default.
• W2018184554 cites W149179782 @default.
• W2018184554 cites W1507228972 @default.
• W2018184554 cites W1514066364 @default.
• W2018184554 cites W1528696665 @default.
• W2018184554 cites W1540746382 @default.
• W2018184554 cites W1542006519 @default.
• W2018184554 cites W1656644300 @default.
• W2018184554 cites W1671027038 @default.
• W2018184554 cites W1676765468 @default.
• W2018184554 cites W1905490886 @default.
• W2018184554 cites W1931927941 @default.
• W2018184554 cites W1964839077 @default.
• W2018184554 cites W1965145904 @default.
• W2018184554 cites W1973454785 @default.
• W2018184554 cites W1999929858 @default.
• W2018184554 cites W2004017438 @default.
• W2018184554 cites W2010533174 @default.
• W2018184554 cites W2013520717 @default.
• W2018184554 cites W2031399606 @default.
• W2018184554 cites W2033779120 @default.
• W2018184554 cites W2035393016 @default.
• W2018184554 cites W2040730664 @default.
• W2018184554 cites W2042973128 @default.
• W2018184554 cites W2049352024 @default.
• W2018184554 cites W2054659401 @default.
• W2018184554 cites W2062129029 @default.
• W2018184554 cites W2071650600 @default.
• W2018184554 cites W2074217926 @default.
• W2018184554 cites W2080010271 @default.
• W2018184554 cites W2086021309 @default.
• W2018184554 cites W2105338223 @default.
• W2018184554 cites W2343759632 @default.
• W2018184554 cites W2409622393 @default.
• W2018184554 cites W2413964541 @default.
• W2018184554 cites W2804275696 @default.
• W2018184554 cites W4293247451 @default.
• W2018184554 doi "https://doi.org/10.1038/sj.bjp.0702242" @default.
• W2018184554 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1565753" @default.
• W2018184554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9886756" @default.
• W2018184554 hasPublicationYear "1998" @default.
• W2018184554 type Work @default.
• W2018184554 sameAs 2018184554 @default.
• W2018184554 citedByCount "24" @default.
• W2018184554 countsByYear W20181845542013 @default.
• W2018184554 countsByYear W20181845542015 @default.
• W2018184554 crossrefType "journal-article" @default.
• W2018184554 hasAuthorship W2018184554A5004419638 @default.
• W2018184554 hasAuthorship W2018184554A5010531715 @default.
• W2018184554 hasAuthorship W2018184554A5027728106 @default.
• W2018184554 hasAuthorship W2018184554A5038163394 @default.
• W2018184554 hasAuthorship W2018184554A5038192407 @default.
• W2018184554 hasAuthorship W2018184554A5038246750 @default.
• W2018184554 hasAuthorship W2018184554A5059316181 @default.
• W2018184554 hasAuthorship W2018184554A5064448710 @default.
• W2018184554 hasBestOaLocation W20181845541 @default.
• W2018184554 hasConcept C1122143 @default.
• W2018184554 hasConcept C126322002 @default.
• W2018184554 hasConcept C134018914 @default.
• W2018184554 hasConcept C185592680 @default.
• W2018184554 hasConcept C195794163 @default.
• W2018184554 hasConcept C2777093181 @default.
• W2018184554 hasConcept C2777952589 @default.
• W2018184554 hasConcept C2779178603 @default.
• W2018184554 hasConcept C2780245509 @default.
• W2018184554 hasConcept C55493867 @default.
• W2018184554 hasConcept C62478195 @default.
• W2018184554 hasConcept C71924100 @default.
• W2018184554 hasConcept C80631254 @default.
• W2018184554 hasConcept C84393581 @default.
• W2018184554 hasConcept C86803240 @default.
• W2018184554 hasConceptScore W2018184554C1122143 @default.
• W2018184554 hasConceptScore W2018184554C126322002 @default.
• W2018184554 hasConceptScore W2018184554C134018914 @default.
• W2018184554 hasConceptScore W2018184554C185592680 @default.
• W2018184554 hasConceptScore W2018184554C195794163 @default.
• W2018184554 hasConceptScore W2018184554C2777093181 @default.
• W2018184554 hasConceptScore W2018184554C2777952589 @default.
• W2018184554 hasConceptScore W2018184554C2779178603 @default.
• W2018184554 hasConceptScore W2018184554C2780245509 @default.
• W2018184554 hasConceptScore W2018184554C55493867 @default.
• W2018184554 hasConceptScore W2018184554C62478195 @default.
• W2018184554 hasConceptScore W2018184554C71924100 @default.
• W2018184554 hasConceptScore W2018184554C80631254 @default.
• W2018184554 hasConceptScore W2018184554C84393581 @default.
• W2018184554 hasConceptScore W2018184554C86803240 @default.

• next