Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018185881> ?p ?o ?g. }
Showing items 1 to 87 of
87
with 100 items per page.
- W2018185881 abstract "Cytochrome P450 (CYP) 3A is responsible for about 50% of drug metabolizing activity in the liver. The present study was undertaken to establish a CYP3A4-active model for in vitro analysis of human drug metabolism. The cells used were immortalized normal human fetal hepatocytes (OUMS-29) and its HNF4alpha-introduced subline (OUMS-29/H-11). The cells were cultivated under high-density three-dimensional conditions in a radial-flow bioreactor (RFB). The number of OUMS-29 cells increased 15-fold over 49 days and their apical surfaces were covered with abundant microvilli, a characteristic of hepatocytes in vivo. The amount of albumin secreted by OUMS-29 cells in the three-dimensional RFB culture was 6-fold higher than those in a monolayer culture. CYP3A4 protein and an intermediate metabolite of testosterone by CYP3A4 were detected in OUMS-29/H11 cells cultivated in RFB >29 days. These results indicate that the RFB culture of OUMS-29/H-11 cells is useful for screening and developing new drugs." @default.
- W2018185881 created "2016-06-24" @default.
- W2018185881 creator A5003556296 @default.
- W2018185881 creator A5009894994 @default.
- W2018185881 creator A5021973822 @default.
- W2018185881 creator A5025540607 @default.
- W2018185881 creator A5036361321 @default.
- W2018185881 creator A5054018959 @default.
- W2018185881 creator A5057147192 @default.
- W2018185881 creator A5057857434 @default.
- W2018185881 creator A5061221003 @default.
- W2018185881 creator A5067360623 @default.
- W2018185881 date "2004-10-01" @default.
- W2018185881 modified "2023-09-24" @default.
- W2018185881 title "Expression of CYP3A4 by an immortalized human hepatocyte line in a three-dimensional culture using a radial-flow bioreactor." @default.
- W2018185881 doi "https://doi.org/10.3892/ijmm.14.4.663" @default.
- W2018185881 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15375599" @default.
- W2018185881 hasPublicationYear "2004" @default.
- W2018185881 type Work @default.
- W2018185881 sameAs 2018185881 @default.
- W2018185881 citedByCount "4" @default.
- W2018185881 countsByYear W20181858812014 @default.
- W2018185881 countsByYear W20181858812017 @default.
- W2018185881 crossrefType "journal-article" @default.
- W2018185881 hasAuthorship W2018185881A5003556296 @default.
- W2018185881 hasAuthorship W2018185881A5009894994 @default.
- W2018185881 hasAuthorship W2018185881A5021973822 @default.
- W2018185881 hasAuthorship W2018185881A5025540607 @default.
- W2018185881 hasAuthorship W2018185881A5036361321 @default.
- W2018185881 hasAuthorship W2018185881A5054018959 @default.
- W2018185881 hasAuthorship W2018185881A5057147192 @default.
- W2018185881 hasAuthorship W2018185881A5057857434 @default.
- W2018185881 hasAuthorship W2018185881A5061221003 @default.
- W2018185881 hasAuthorship W2018185881A5067360623 @default.
- W2018185881 hasBestOaLocation W20181858812 @default.
- W2018185881 hasConcept C109650736 @default.
- W2018185881 hasConcept C153911025 @default.
- W2018185881 hasConcept C202751555 @default.
- W2018185881 hasConcept C207001950 @default.
- W2018185881 hasConcept C2776200302 @default.
- W2018185881 hasConcept C2777477808 @default.
- W2018185881 hasConcept C526171541 @default.
- W2018185881 hasConcept C54355233 @default.
- W2018185881 hasConcept C553184892 @default.
- W2018185881 hasConcept C55493867 @default.
- W2018185881 hasConcept C6045943 @default.
- W2018185881 hasConcept C62231903 @default.
- W2018185881 hasConcept C81885089 @default.
- W2018185881 hasConcept C86803240 @default.
- W2018185881 hasConcept C89311334 @default.
- W2018185881 hasConcept C95444343 @default.
- W2018185881 hasConceptScore W2018185881C109650736 @default.
- W2018185881 hasConceptScore W2018185881C153911025 @default.
- W2018185881 hasConceptScore W2018185881C202751555 @default.
- W2018185881 hasConceptScore W2018185881C207001950 @default.
- W2018185881 hasConceptScore W2018185881C2776200302 @default.
- W2018185881 hasConceptScore W2018185881C2777477808 @default.
- W2018185881 hasConceptScore W2018185881C526171541 @default.
- W2018185881 hasConceptScore W2018185881C54355233 @default.
- W2018185881 hasConceptScore W2018185881C553184892 @default.
- W2018185881 hasConceptScore W2018185881C55493867 @default.
- W2018185881 hasConceptScore W2018185881C6045943 @default.
- W2018185881 hasConceptScore W2018185881C62231903 @default.
- W2018185881 hasConceptScore W2018185881C81885089 @default.
- W2018185881 hasConceptScore W2018185881C86803240 @default.
- W2018185881 hasConceptScore W2018185881C89311334 @default.
- W2018185881 hasConceptScore W2018185881C95444343 @default.
- W2018185881 hasLocation W20181858811 @default.
- W2018185881 hasLocation W20181858812 @default.
- W2018185881 hasLocation W20181858813 @default.
- W2018185881 hasLocation W20181858814 @default.
- W2018185881 hasOpenAccess W2018185881 @default.
- W2018185881 hasPrimaryLocation W20181858811 @default.
- W2018185881 hasRelatedWork W1987184539 @default.
- W2018185881 hasRelatedWork W1997245539 @default.
- W2018185881 hasRelatedWork W2010245523 @default.
- W2018185881 hasRelatedWork W2018185881 @default.
- W2018185881 hasRelatedWork W2095442432 @default.
- W2018185881 hasRelatedWork W2103825636 @default.
- W2018185881 hasRelatedWork W2181095125 @default.
- W2018185881 hasRelatedWork W2209524608 @default.
- W2018185881 hasRelatedWork W2918194956 @default.
- W2018185881 hasRelatedWork W3097105836 @default.
- W2018185881 isParatext "false" @default.
- W2018185881 isRetracted "false" @default.
- W2018185881 magId "2018185881" @default.
- W2018185881 workType "article" @default.