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- W2018187444 abstract "A radial immunodiffusion assay for apolipoprotein C-I in human serum and lipoproteins was developed and validated by comparison with analysis of these proteins in very-low-density and high-density lipoproteins by quantitative polyacrylamide gel electrophoresis. In normotriglyceridemic subjects, only about 10% of apoprotein C-I was in very-low-density lipoproteins; almost all of the remainder was in high-density lipoproteins. In subjects with widely varying serum triglyceride levels, apoprotein C-I comprised about 4% of the total apoprotein of the triglyceride-rich lipoproteins. In normotriglyceridemic subjects, apoprotein C-I comprised about 3% of the total apoprotein of high-density lipoproteins; this value was about twice as great in the high-density lipoproteins of density 1.063–1.125 g/ml as in those of density 1.125–1.21 g/ml. With increasing serum triglyceride level, the percentage of apoprotein C-I in triglyceride-rich lipoproteins increased and that in high-density lipoproteins fell progressively. Whereas apoprotein C-I comprised about 9% of the mass of the proteins of low molecular weight (<12,000) in very-low-density lipoproteins, it comprised about one-third of the mass of these proteins in high-density lipoproteins. As compared with the other major proteins of low molecular weight in human plasma lipoproteins (apoprotein C-II and apoprotein C-III), apoprotein C-I is therefore preferentially distributed in high-density lipoproteins. The average concentration of apoprotein C-I in serum of normotriglyceridemic individuals was 7 mg/dl; the concentration was not systematically increased in patients with primary hypertriglyceridemias." @default.
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- W2018187444 title "Human apolipoprotein C-I: Concentration in blood serum and lipoproteins" @default.
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