Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018188002> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2018188002 abstract "We have evaluated three-week-old compression lesions of the rat spinal cord using two-dimensional and three-dimensional morphometry, reconstruction, and visualization techniques. We offer a new computer assisted method to determine the number and density of macrophages within the spinal lesion using the macrophage specific monoclonal label ED1. We also provide quantitative information on pathological cyst formation and cavitation. This technique does not require: (1) subjective identification of the cell type, (2) human interaction with the data during the phase of quantification, and (3) can be applied to any sampling paradigm based on immunocytochemical labeling. Using novel algorithms based on solutions to 'correspondence' and 'branching' problems inherent in cross-sectional histological data, we provide three-dimensional reconstructions and visualizations of the macrophagic lesions and cysts imbedded within it. Our three-dimensional surface reconstructions can be interrogated to determine volumes and surface areas of structures within the data set. Using these methods we have learned that macrophage numbers approach the maximum density possible for such isodiametric cells (approximately 12 microm diameter) in the central lesion ranging from 4000-7000 cells per mm2 of lesion. At the time point studied, macrophage numbers would have peaked following the initial insult, and would not be expected to decline for several months. While the density of macrophages is highest in the region of most tissue damage, we show that the central regions of cavitated and cystic spinal parenchyma is not. We discuss how this density of cells may effect the secondary pathological responses of the spinal cord to injury." @default.
- W2018188002 created "2016-06-24" @default.
- W2018188002 creator A5012554172 @default.
- W2018188002 creator A5030896164 @default.
- W2018188002 creator A5045100984 @default.
- W2018188002 creator A5058599511 @default.
- W2018188002 creator A5062365477 @default.
- W2018188002 date "1998-03-01" @default.
- W2018188002 modified "2023-09-27" @default.
- W2018188002 title "Two- and three-dimensional computer graphic evaluation of the subacute spinal cord injury" @default.
- W2018188002 cites W1557501694 @default.
- W2018188002 cites W1995261715 @default.
- W2018188002 cites W1999706672 @default.
- W2018188002 cites W2001810885 @default.
- W2018188002 cites W2037711162 @default.
- W2018188002 cites W2055404309 @default.
- W2018188002 cites W2066533648 @default.
- W2018188002 cites W2068384471 @default.
- W2018188002 cites W2076162707 @default.
- W2018188002 cites W2087251720 @default.
- W2018188002 cites W2090998971 @default.
- W2018188002 cites W2093664333 @default.
- W2018188002 cites W2113015402 @default.
- W2018188002 cites W2121390857 @default.
- W2018188002 cites W2129706561 @default.
- W2018188002 cites W2130333176 @default.
- W2018188002 cites W2147311935 @default.
- W2018188002 cites W2160353065 @default.
- W2018188002 cites W2400049961 @default.
- W2018188002 cites W2485584893 @default.
- W2018188002 cites W4232157339 @default.
- W2018188002 doi "https://doi.org/10.1016/s0022-510x(97)00203-7" @default.
- W2018188002 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9562256" @default.
- W2018188002 hasPublicationYear "1998" @default.
- W2018188002 type Work @default.
- W2018188002 sameAs 2018188002 @default.
- W2018188002 citedByCount "34" @default.
- W2018188002 countsByYear W20181880022012 @default.
- W2018188002 countsByYear W20181880022013 @default.
- W2018188002 countsByYear W20181880022018 @default.
- W2018188002 crossrefType "journal-article" @default.
- W2018188002 hasAuthorship W2018188002A5012554172 @default.
- W2018188002 hasAuthorship W2018188002A5030896164 @default.
- W2018188002 hasAuthorship W2018188002A5045100984 @default.
- W2018188002 hasAuthorship W2018188002A5058599511 @default.
- W2018188002 hasAuthorship W2018188002A5062365477 @default.
- W2018188002 hasConcept C105702510 @default.
- W2018188002 hasConcept C142724271 @default.
- W2018188002 hasConcept C169760540 @default.
- W2018188002 hasConcept C196822366 @default.
- W2018188002 hasConcept C202751555 @default.
- W2018188002 hasConcept C207886595 @default.
- W2018188002 hasConcept C2778334475 @default.
- W2018188002 hasConcept C2779244956 @default.
- W2018188002 hasConcept C2780775167 @default.
- W2018188002 hasConcept C2781156865 @default.
- W2018188002 hasConcept C55493867 @default.
- W2018188002 hasConcept C71924100 @default.
- W2018188002 hasConcept C86803240 @default.
- W2018188002 hasConceptScore W2018188002C105702510 @default.
- W2018188002 hasConceptScore W2018188002C142724271 @default.
- W2018188002 hasConceptScore W2018188002C169760540 @default.
- W2018188002 hasConceptScore W2018188002C196822366 @default.
- W2018188002 hasConceptScore W2018188002C202751555 @default.
- W2018188002 hasConceptScore W2018188002C207886595 @default.
- W2018188002 hasConceptScore W2018188002C2778334475 @default.
- W2018188002 hasConceptScore W2018188002C2779244956 @default.
- W2018188002 hasConceptScore W2018188002C2780775167 @default.
- W2018188002 hasConceptScore W2018188002C2781156865 @default.
- W2018188002 hasConceptScore W2018188002C55493867 @default.
- W2018188002 hasConceptScore W2018188002C71924100 @default.
- W2018188002 hasConceptScore W2018188002C86803240 @default.
- W2018188002 hasLocation W20181880021 @default.
- W2018188002 hasLocation W20181880022 @default.
- W2018188002 hasOpenAccess W2018188002 @default.
- W2018188002 hasPrimaryLocation W20181880021 @default.
- W2018188002 hasRelatedWork W1482711476 @default.
- W2018188002 hasRelatedWork W2007964197 @default.
- W2018188002 hasRelatedWork W2018188002 @default.
- W2018188002 hasRelatedWork W2063877300 @default.
- W2018188002 hasRelatedWork W2076012833 @default.
- W2018188002 hasRelatedWork W2152959946 @default.
- W2018188002 hasRelatedWork W2388566014 @default.
- W2018188002 hasRelatedWork W2405872984 @default.
- W2018188002 hasRelatedWork W280501672 @default.
- W2018188002 hasRelatedWork W120465808 @default.
- W2018188002 isParatext "false" @default.
- W2018188002 isRetracted "false" @default.
- W2018188002 magId "2018188002" @default.
- W2018188002 workType "article" @default.