Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018190711> ?p ?o ?g. }
- W2018190711 endingPage "543" @default.
- W2018190711 startingPage "533" @default.
- W2018190711 abstract "Ligands for epidermal growth factor (EGF) receptor (ErbB1), such as EGF, transforming growth factor alpha (TGFα), and epiregulin, are enriched in body fluids and blood and regulate development of various peripheral organs. It remains however how such circulating polypeptide growth factors influence brain development and function. Here, we performed peripheral injections of TGFα and epiregulin to mouse neonates and evaluated immediate physical and neurochemical development and later behavioral consequences. Subcutaneous administration of TGFα and epiregulin increased phosphorylation of brain ErbB1, suggesting their effects on brain development. Repeated their injections similarly enhanced physical development of eyelid opening and tooth eruption during early postnatal stage and resulted in abnormal behavioral traits in the adult stage. Acoustic startle responses of mice treated with these growth factors as neonates were enhanced and prepulse inhibition was decreased without an apparent correlation between prepulse inhibition level and startle intensity. Locomotor activity and fear-learning performance with tone and context cues were not altered, however. These results suggest that circulating ErbB1 ligands in the periphery of neonates have some common influences on later behavioral traits. Abnormal ErbB1 ligand production at neonatal and potentially prenatal stages might therefore associate with neurodevelopmental disorders such as schizophrenia." @default.
- W2018190711 created "2016-06-24" @default.
- W2018190711 creator A5011126050 @default.
- W2018190711 creator A5025506568 @default.
- W2018190711 creator A5051358461 @default.
- W2018190711 creator A5061069554 @default.
- W2018190711 creator A5080553016 @default.
- W2018190711 creator A5086338873 @default.
- W2018190711 date "2008-09-01" @default.
- W2018190711 modified "2023-10-15" @default.
- W2018190711 title "Common behavioral influences of the ErbB1 ligands transforming growth factor alpha and epiregulin administered to mouse neonates" @default.
- W2018190711 cites W1501383613 @default.
- W2018190711 cites W1820089171 @default.
- W2018190711 cites W1979818739 @default.
- W2018190711 cites W1980073907 @default.
- W2018190711 cites W1980967004 @default.
- W2018190711 cites W1982681624 @default.
- W2018190711 cites W1984305433 @default.
- W2018190711 cites W1984725265 @default.
- W2018190711 cites W1997218550 @default.
- W2018190711 cites W2000230045 @default.
- W2018190711 cites W2003610823 @default.
- W2018190711 cites W2012322739 @default.
- W2018190711 cites W2020682158 @default.
- W2018190711 cites W2021640988 @default.
- W2018190711 cites W2024795049 @default.
- W2018190711 cites W2030358701 @default.
- W2018190711 cites W2035713221 @default.
- W2018190711 cites W2037358901 @default.
- W2018190711 cites W2038008697 @default.
- W2018190711 cites W2038086562 @default.
- W2018190711 cites W2038159281 @default.
- W2018190711 cites W2039868323 @default.
- W2018190711 cites W2042878503 @default.
- W2018190711 cites W2045286275 @default.
- W2018190711 cites W2048679627 @default.
- W2018190711 cites W2053671284 @default.
- W2018190711 cites W2060523967 @default.
- W2018190711 cites W2062899433 @default.
- W2018190711 cites W2068272793 @default.
- W2018190711 cites W2069878546 @default.
- W2018190711 cites W2077989508 @default.
- W2018190711 cites W2079349879 @default.
- W2018190711 cites W2091756467 @default.
- W2018190711 cites W2092696839 @default.
- W2018190711 cites W2093780531 @default.
- W2018190711 cites W2103834956 @default.
- W2018190711 cites W2130620798 @default.
- W2018190711 cites W2139731895 @default.
- W2018190711 cites W2147450013 @default.
- W2018190711 cites W2150543872 @default.
- W2018190711 cites W2160073148 @default.
- W2018190711 cites W2169039337 @default.
- W2018190711 doi "https://doi.org/10.1016/j.braindev.2008.01.006" @default.
- W2018190711 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18313247" @default.
- W2018190711 hasPublicationYear "2008" @default.
- W2018190711 type Work @default.
- W2018190711 sameAs 2018190711 @default.
- W2018190711 citedByCount "16" @default.
- W2018190711 countsByYear W20181907112013 @default.
- W2018190711 countsByYear W20181907112014 @default.
- W2018190711 countsByYear W20181907112015 @default.
- W2018190711 countsByYear W20181907112017 @default.
- W2018190711 countsByYear W20181907112019 @default.
- W2018190711 countsByYear W20181907112021 @default.
- W2018190711 countsByYear W20181907112022 @default.
- W2018190711 countsByYear W20181907112023 @default.
- W2018190711 crossrefType "journal-article" @default.
- W2018190711 hasAuthorship W2018190711A5011126050 @default.
- W2018190711 hasAuthorship W2018190711A5025506568 @default.
- W2018190711 hasAuthorship W2018190711A5051358461 @default.
- W2018190711 hasAuthorship W2018190711A5061069554 @default.
- W2018190711 hasAuthorship W2018190711A5080553016 @default.
- W2018190711 hasAuthorship W2018190711A5086338873 @default.
- W2018190711 hasConcept C118131993 @default.
- W2018190711 hasConcept C118552586 @default.
- W2018190711 hasConcept C125555471 @default.
- W2018190711 hasConcept C126322002 @default.
- W2018190711 hasConcept C134018914 @default.
- W2018190711 hasConcept C141421786 @default.
- W2018190711 hasConcept C151730666 @default.
- W2018190711 hasConcept C15744967 @default.
- W2018190711 hasConcept C169760540 @default.
- W2018190711 hasConcept C170493617 @default.
- W2018190711 hasConcept C25876315 @default.
- W2018190711 hasConcept C2775960820 @default.
- W2018190711 hasConcept C2776362946 @default.
- W2018190711 hasConcept C2776412080 @default.
- W2018190711 hasConcept C2777968868 @default.
- W2018190711 hasConcept C2779343474 @default.
- W2018190711 hasConcept C2780806702 @default.
- W2018190711 hasConcept C71924100 @default.
- W2018190711 hasConcept C86803240 @default.
- W2018190711 hasConceptScore W2018190711C118131993 @default.
- W2018190711 hasConceptScore W2018190711C118552586 @default.
- W2018190711 hasConceptScore W2018190711C125555471 @default.
- W2018190711 hasConceptScore W2018190711C126322002 @default.
- W2018190711 hasConceptScore W2018190711C134018914 @default.