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- W2018194902 abstract "Neonatal lupus syndromes are caused by maternal antibodies targeting proteins displayed on apoptotic blebs. Mothers frequently are healthy and unaware of their autoantibody status. Manifestations in infants include rashes, cytopenias, hepatobiliary disease, heart block, and rarely, cardiomyopathies. Cerebral dysmaturation, ventriculomegaly, and lenticulostriate vasculopathy are recently described manifestations. Rhizomelic chondrodysplasia punctata, pneumonitis, nephritis, and multiorgan failure are rare. Coexisting antithyroid and antiphospholipid antibodies may complicate the presentation. Symptoms typically disappear with the clearance of maternal antibodies from the neonatal circulation, except in cases where the disease is extensive or involves vulnerable tissues. Early diagnosis, close monitoring, and appropriate intervention with immunosuppressive treatment may subvert organ-threatening disease in select cases." @default.
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- W2018194902 date "2008-05-01" @default.
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- W2018194902 title "Neonatal Lupus and Related Autoimmune Disorders of Infants" @default.
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- W2018194902 doi "https://doi.org/10.1542/neo.9-5-e206" @default.
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